It's a lot easier to test accessibility on the fly using ADB. This gist attempts to make the days of navigating through the Android device settings UI to change Accessibility settings obsolete.
These ADB commands will hopefully encourage Android developers to test and use their apps with common Accessiblility settings enabled.
Credit to James Nitsch for inspiring this, and for figuring out the put commands to enable these settings.
Update 2025-07-16: Use either Revanced, NewPipe or Firefox with add-ons. Revanced is my personal pick, due to it being a mod of the official App like Vanced, but better (e.g. it has integration of Sponsor Block, Return YouTube Disklike and more).
I wouldn't recommend Kiwi Browser anymore as it has been discontinued. AFAIK it has been accuired by Microsoft and the extension support has been merged into Edge (Canary). But you'd have to use Edge. Yuck.