gamax92's wine repo has the DirectX11 overwatch patches already applied. We need to build this version of Wine with WOW64 support. That is, the 64-bit version of wine which also supports 32-bit Windows programs. In so many words: if your CPU is 32-bit only, don't bother and you couldn't run Overwatch anyway.
Building wine with WOW64 support requires boostrapping the final build. The three stages look like:
- Build the 64-bit version of wine (pass --enable-win64 to ./configure)