For best performance use a kernel with fsync support, like xanmod.
At the time of writing, 6.2.12-x64v4-xanmod1 is installed.
Also update your graphics drivers! Like https://launchpad.net/~oibaf/+archive/ubuntu/graphics-drivers
Download the newest Glorious Eggroll Wine version here: https://github.com/GloriousEggroll/wine-ge-custom/releases At the time of writing it is https://github.com/GloriousEggroll/wine-ge-custom/releases/download/GE-Proton8-8/wine-lutris-GE-Proton8-8-x86_64.tar.xz
Here is a table of all env params used: