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prosolo flamegraph at libprosic local branch commit to calculate LogProb of allele_freq_case and allele_freq_control once per pileup, not per observation (for interactive SVG, right-click thumbnail and choose `View image`)
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<title>&lt;bio::stats::probs::LogProb as core::ops::arith::Add&gt;::add (596 samples, 0.30%)</title><rect x="231.6" y="197" width="3.5" height="15.0" fill="rgb(238,139,0)" rx="2" ry="2" />
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<title>&lt;alloc::collections::btree::node::Handle&lt;alloc::collections::btree::node::NodeRef&lt;alloc::collections::btree::node::marker::Mut&lt;'a&gt;, K, V, alloc::collections::btree::node::marker::Leaf&gt;, alloc::collections::btree::node::marker::Edge&gt;&gt;::insert (99 samples, 0.05%)</title><rect x="209.5" y="197" width="0.6" height="15.0" fill="rgb(216,217,10)" rx="2" ry="2" />
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<title>init (1,191 samples, 0.59%)</title><rect x="12.3" y="437" width="7.0" height="15.0" fill="rgb(235,91,29)" rx="2" ry="2" />
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<title>[unknown] (23 samples, 0.01%)</title><rect x="1177.6" y="165" width="0.1" height="15.0" fill="rgb(211,214,18)" rx="2" ry="2" />
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<title>&lt;rust_htslib::bcf::Reader as rust_htslib::bcf::Read&gt;::read (170 samples, 0.08%)</title><rect x="1172.4" y="293" width="1.0" height="15.0" fill="rgb(223,89,14)" rx="2" ry="2" />
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<title>rust_htslib::bcf::record::Info::integer (67 samples, 0.03%)</title><rect x="1178.2" y="277" width="0.4" height="15.0" fill="rgb(237,186,47)" rx="2" ry="2" />
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<title>crc32 (26 samples, 0.01%)</title><rect x="41.6" y="149" width="0.1" height="15.0" fill="rgb(205,17,36)" rx="2" ry="2" />
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<title>_ieee754_exp_avx (22,342 samples, 11.11%)</title><rect x="918.1" y="197" width="131.2" height="15.0" fill="rgb(254,128,42)" rx="2" ry="2" />
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<title>hts_itr_next (232 samples, 0.12%)</title><rect x="41.2" y="229" width="1.4" height="15.0" fill="rgb(251,14,44)" rx="2" ry="2" />
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<title>arena_bin_malloc_hard (18 samples, 0.01%)</title><rect x="55.5" y="101" width="0.1" height="15.0" fill="rgb(220,220,30)" rx="2" ry="2" />
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<title>prosolo::call::alignment_properties (28 samples, 0.01%)</title><rect x="1189.8" y="309" width="0.2" height="15.0" fill="rgb(224,32,1)" rx="2" ry="2" />
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<title>bio::stats::probs::&lt;impl core::convert::From&lt;bio::stats::probs::LogProb&gt; for ordered_float::NotNaN&lt;f64&gt;&gt;::from (26 samples, 0.01%)</title><rect x="40.8" y="261" width="0.2" height="15.0" fill="rgb(215,216,36)" rx="2" ry="2" />
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<title>je_arena_ralloc (321 samples, 0.16%)</title><rect x="85.8" y="133" width="1.9" height="15.0" fill="rgb(231,172,48)" rx="2" ry="2" />
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<title>&lt;bio::io::fasta::IndexedReader&lt;R&gt;&gt;::read (208 samples, 0.10%)</title><rect x="1176.8" y="277" width="1.2" height="15.0" fill="rgb(215,119,45)" rx="2" ry="2" />
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<title>kputc (60 samples, 0.03%)</title><rect x="1188.0" y="245" width="0.3" height="15.0" fill="rgb(222,86,48)" rx="2" ry="2" />
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<title>&lt;alloc::vec::Vec&lt;T&gt; as alloc::vec::SpecExtend&lt;T, I&gt;&gt;::from_iter (164,005 samples, 81.58%)</title><rect x="197.2" y="277" width="962.6" height="15.0" fill="rgb(224,98,22)" rx="2" ry="2" />
<text text-anchor="" x="200.23" y="287.5" font-size="12" font-family="Verdana" fill="rgb(0,0,0)" >&lt;alloc::vec::Vec&lt;T&gt; as alloc::vec::SpecExtend&lt;T, I&gt;&gt;::from_iter</text>
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<title>&lt;alloc::vec::Vec&lt;T&gt; as alloc::vec::SpecExtend&lt;T, I&gt;&gt;::from_iter (1,253 samples, 0.62%)</title><rect x="1162.7" y="245" width="7.4" height="15.0" fill="rgb(210,35,20)" rx="2" ry="2" />
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<title>_w_log1p (66 samples, 0.03%)</title><rect x="887.7" y="229" width="0.4" height="15.0" fill="rgb(237,228,11)" rx="2" ry="2" />
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<title>core::slice::&lt;impl [T]&gt;::copy_from_slice (52 samples, 0.03%)</title><rect x="1177.7" y="261" width="0.3" height="15.0" fill="rgb(207,225,44)" rx="2" ry="2" />
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<title>rust_htslib::bam::record::Record::cigar_cached (52 samples, 0.03%)</title><rect x="104.3" y="261" width="0.3" height="15.0" fill="rgb(249,83,12)" rx="2" ry="2" />
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<title>&lt;alloc::vec::Vec&lt;T&gt; as alloc::vec::SpecExtend&lt;T, I&gt;&gt;::from_iter (33 samples, 0.02%)</title><rect x="21.3" y="293" width="0.2" height="15.0" fill="rgb(241,69,10)" rx="2" ry="2" />
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<title>_memcpy_avx_unaligned (54 samples, 0.03%)</title><rect x="64.6" y="101" width="0.3" height="15.0" fill="rgb(247,50,10)" rx="2" ry="2" />
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<title>bio::stats::probs::LogProb::ln_one_minus_exp (25 samples, 0.01%)</title><rect x="95.3" y="229" width="0.2" height="15.0" fill="rgb(229,104,16)" rx="2" ry="2" />
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<title>core::slice::&lt;impl [T]&gt;::copy_from_slice (91 samples, 0.05%)</title><rect x="64.4" y="117" width="0.5" height="15.0" fill="rgb(205,43,40)" rx="2" ry="2" />
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<title>_log1p (25 samples, 0.01%)</title><rect x="1161.9" y="261" width="0.1" height="15.0" fill="rgb(241,171,2)" rx="2" ry="2" />
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<title>rust_htslib::bam::record::Record::pos (26 samples, 0.01%)</title><rect x="43.5" y="245" width="0.2" height="15.0" fill="rgb(249,150,7)" rx="2" ry="2" />
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<title>_w_log1p (272 samples, 0.14%)</title><rect x="1109.6" y="213" width="1.6" height="15.0" fill="rgb(212,48,3)" rx="2" ry="2" />
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<title>memchr (130 samples, 0.06%)</title><rect x="82.1" y="181" width="0.8" height="15.0" fill="rgb(240,176,27)" rx="2" ry="2" />
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<title>libprosic::call::pairwise::call (199,155 samples, 99.06%)</title><rect x="20.9" y="309" width="1168.9" height="15.0" fill="rgb(252,221,16)" rx="2" ry="2" />
<text text-anchor="" x="23.90" y="319.5" font-size="12" font-family="Verdana" fill="rgb(0,0,0)" >libprosic::call::pairwise::call</text>
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<title>bcf_enc_vfloat (39 samples, 0.02%)</title><rect x="1188.3" y="261" width="0.3" height="15.0" fill="rgb(230,125,51)" rx="2" ry="2" />
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<title>_log (658 samples, 0.33%)</title><rect x="373.1" y="197" width="3.9" height="15.0" fill="rgb(210,58,21)" rx="2" ry="2" />
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<title>_ieee754_exp_avx (171 samples, 0.09%)</title><rect x="45.8" y="213" width="1.0" height="15.0" fill="rgb(228,133,26)" rx="2" ry="2" />
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<title>_libc_start_main (199,185 samples, 99.08%)</title><rect x="20.9" y="437" width="1169.1" height="15.0" fill="rgb(233,201,19)" rx="2" ry="2" />
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<title>bio::stats::probs::LogProb::ln_one (141 samples, 0.07%)</title><rect x="1111.2" y="229" width="0.8" height="15.0" fill="rgb(242,169,21)" rx="2" ry="2" />
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<title>rust_htslib::bam::record::CigarStringView::end_pos (619 samples, 0.31%)</title><rect x="100.3" y="245" width="3.6" height="15.0" fill="rgb(215,55,46)" rx="2" ry="2" />
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<title>_ieee754_exp_avx (23 samples, 0.01%)</title><rect x="95.3" y="197" width="0.2" height="15.0" fill="rgb(220,159,38)" rx="2" ry="2" />
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<title>log::_log (620 samples, 0.31%)</title><rect x="1178.7" y="293" width="3.7" height="15.0" fill="rgb(248,38,35)" rx="2" ry="2" />
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<title>deflate (711 samples, 0.35%)</title><rect x="1183.3" y="213" width="4.2" height="15.0" fill="rgb(225,61,14)" rx="2" ry="2" />
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<title>@plt (313 samples, 0.16%)</title><rect x="10.5" y="437" width="1.8" height="15.0" fill="rgb(212,155,30)" rx="2" ry="2" />
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<title>rust_htslib::bcf::record::Record::push_info_float (355 samples, 0.18%)</title><rect x="1187.6" y="293" width="2.1" height="15.0" fill="rgb(242,143,51)" rx="2" ry="2" />
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<title>_GI___exp (257 samples, 0.13%)</title><rect x="1160.4" y="261" width="1.5" height="15.0" fill="rgb(223,51,16)" rx="2" ry="2" />
<text text-anchor="" x="1163.38" y="271.5" font-size="12" font-family="Verdana" fill="rgb(0,0,0)" ></text>
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<title>_ieee754_exp_avx (557 samples, 0.28%)</title><rect x="710.0" y="213" width="3.3" height="15.0" fill="rgb(213,190,0)" rx="2" ry="2" />
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<title>libprosic::utils::collect_variants (118 samples, 0.06%)</title><rect x="1178.0" y="293" width="0.7" height="15.0" fill="rgb(235,112,5)" rx="2" ry="2" />
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<title>alloc::collections::btree::search::search_tree (107 samples, 0.05%)</title><rect x="210.2" y="197" width="0.6" height="15.0" fill="rgb(212,214,32)" rx="2" ry="2" />
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<title>_ieee754_exp_avx (23,613 samples, 11.75%)</title><rect x="432.5" y="165" width="138.6" height="15.0" fill="rgb(245,4,13)" rx="2" ry="2" />
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<title>[unknown] (288 samples, 0.14%)</title><rect x="1180.1" y="69" width="1.7" height="15.0" fill="rgb(252,36,19)" rx="2" ry="2" />
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