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Genetic Testing and Omics Approaches in Clinical Trials: An Overview for Non-Specialists

In the context of clinical trials, genetic testing and omics approaches play a crucial role in understanding disease mechanisms, drug responses, and individual variations. These methodologies provide researchers with valuable insights that can lead to more targeted and effective treatments. Here's an overview of the key techniques and their applications:

Genetic testing and Omics approaches

A concise overview of the various genetic testing methods and omics approaches used in clinical trial prescreening. It highlights the key features, use cases, and examples for each approach, making it easier to compare and understand their applications in clinical research.

Test/Approach	Description	Use Case	Example

Cypher Query Optimization

Neo4j graph database is based on Guide to Pharmacology ontology
Ontology imported using n10s

Samply Query

WITH ["ns0__EnzymeTargetFamily", 
      "ns0__OtherProteinTargetFamily",

Einar and the Bear - Draft

Prologue: The Pact of Shadows and Light

Before the village of Einar lay under the watchful protection of the Spirit Bear, before the forest whispered secrets through the snow, and before Einar became known as the Bear Slayer, there was a pact—a covenant between the ancient spirits of the forest and the first settlers of the land. This pact was born from necessity, a mutual understanding that for both to thrive, a balance must be maintained.

In the time when the world was younger, when the trees stretched so high they seemed to touch the sky, and the spirits roamed freely among the living, the first villagers sought to make their home at the forest's edge. They understood the sanctity of the land, the sacredness of the woods that teemed with life and ancient magic. In their wisdom, they knew that to live in harmony with such a force, a pact must be made.

The elders of the village, guided by dreams sent by the forest spirits, ventured deep into the heart of the woods, to a c

Setup

Create a new directory with these three files (requirements.txt, main.py, README.md)
python -m venv venv
source venv/bin/activate
pip install -r requirements.txt
python main.py
Update main() to run the example prompt chains

Summary of LangChain's RAG from scratch video series

Source: https://www.youtube.com/playlist?list=PLfaIDFEXuae2LXbO1_PKyVJiQ23ZztA0x

Video	Summary	Links
Part 1 (Overview)	Introduces RAG, outlining the series from basic concepts to advanced techniques.	[Code](https://github.com/langchain-ai/rag-from-scratch/blob/main/rag_from_scratch_1_to_

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	"snippet": {
	"publishedAt": "2024-02-06T01:10:40Z",

	from langchain.chat_models import ChatOpenAI
	from langchain.prompts import ChatPromptTemplate
	from langchain.schema.output_parser import StrOutputParser
	import requests
	from bs4 import BeautifulSoup
	from langchain.schema.runnable import RunnablePassthrough, RunnableLambda
	from langchain.utilities import DuckDuckGoSearchAPIWrapper
	import json

	RESULTS_PER_QUESTION = 3