Untitled.ipynb

{
 "cells": [
  {
   "cell_type": "code",
   "execution_count": 1,
   "metadata": {},
   "outputs": [],
   "source": [
    "import csv\n",
    "import math\n",
    "from copy import deepcopy"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 2,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "{'molecules': {'Acetylcholine': [0.1, 0.2, 0.2, 0.2, 0.1],\n",
       "  'Dopamine': [1.0, 0.9, 0.7, 0.8, 0.9],\n",
       "  'Norepinephrine': [0.1, 0.1, 0.0, 0.1, 0.1],\n",
       "  'Serotonin': [0.2, 0.1, 0.3, 0.1, 0.1]},\n",
       " 'weights': [0.2, 0.2, 0.2, 0.2, 0.2]}"
      ]
     },
     "execution_count": 2,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "def read_csv(filename='./drug_delivery_data.csv'):\n",
    "    with open(filename, newline='') as f:\n",
    "        reader = csv.reader(f)\n",
    "        patients = {}\n",
    "        next(reader)\n",
    "        for id, in_use, molecule, *intensities in reader:\n",
    "            intensities = [float(x) for x in intensities]\n",
    "            patient = patients.setdefault(int(id), {})\n",
    "            if molecule == 'weights':\n",
    "                patient['weights'] = intensities\n",
    "            else:\n",
    "                patient.setdefault('molecules', {})[molecule] = intensities\n",
    "    return patients\n",
    "\n",
    "patients = read_csv()\n",
    "patients[1]"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 3,
   "metadata": {},
   "outputs": [
    {
     "data": {
      "text/plain": [
       "{'Acetylcholine': 0.20255752969966115,\n",
       " 'Dopamine': 0.4079007738512241,\n",
       " 'Norepinephrine': 0.18698416674945367,\n",
       " 'Serotonin': 0.20255752969966115}"
      ]
     },
     "execution_count": 3,
     "metadata": {},
     "output_type": "execute_result"
    }
   ],
   "source": [
    "def get_softmax(patient):\n",
    "    weights = patient['weights']\n",
    "    weighted = {}\n",
    "    for molecule, intensities in patient['molecules'].items():\n",
    "        weighted[molecule] = sum(a * w for a, w in zip(intensities, weights))\n",
    "    denom = sum(math.exp(k) for k in weighted.values())\n",
    "    return {k: math.exp(v) / denom for k, v in weighted.items()}\n",
    "\n",
    "get_softmax(patients[1])"
   ]
  },
  {
   "cell_type": "markdown",
   "metadata": {},
   "source": [
    "## Simulation"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": 4,
   "metadata": {},
   "outputs": [
    {
     "name": "stdout",
     "output_type": "stream",
     "text": [
      "[1] Orig probabily: {'Acetylcholine': 0.20255752969966115, 'Norepinephrine': 0.18698416674945367, 'Dopamine': 0.4079007738512241, 'Serotonin': 0.20255752969966115}\n",
      "[1] Acetylcholine arg-1 maximized: {'Acetylcholine': 0.23318995160706607, 'Norepinephrine': 0.17980148198008516, 'Dopamine': 0.3922319462350304, 'Serotonin': 0.19477662017781835}\n",
      "[1] Acetylcholine arg-2 maximized: {'Acetylcholine': 0.2296328038715248, 'Norepinephrine': 0.18063556134017292, 'Dopamine': 0.39405146722628626, 'Serotonin': 0.195680167562016}\n",
      "[1] Acetylcholine arg-3 maximized: {'Acetylcholine': 0.2296328038715248, 'Norepinephrine': 0.18063556134017292, 'Dopamine': 0.39405146722628626, 'Serotonin': 0.195680167562016}\n",
      "[1] Acetylcholine arg-4 maximized: {'Acetylcholine': 0.2296328038715248, 'Norepinephrine': 0.18063556134017292, 'Dopamine': 0.39405146722628626, 'Serotonin': 0.195680167562016}\n",
      "[1] Acetylcholine arg-5 maximized: {'Acetylcholine': 0.23318995160706604, 'Norepinephrine': 0.17980148198008516, 'Dopamine': 0.3922319462350304, 'Serotonin': 0.19477662017781835}\n",
      "[1] Norepinephrine arg-1 maximized: {'Acetylcholine': 0.1953535690607833, 'Norepinephrine': 0.2158990832682603, 'Dopamine': 0.3933937786101731, 'Serotonin': 0.1953535690607833}\n",
      "[1] Norepinephrine arg-2 maximized: {'Acetylcholine': 0.1953535690607833, 'Norepinephrine': 0.2158990832682603, 'Dopamine': 0.3933937786101731, 'Serotonin': 0.1953535690607833}\n",
      "[1] Norepinephrine arg-3 maximized: {'Acetylcholine': 0.19450524401013686, 'Norepinephrine': 0.2193040502371075, 'Dopamine': 0.39168546174261876, 'Serotonin': 0.19450524401013686}\n",
      "[1] Norepinephrine arg-4 maximized: {'Acetylcholine': 0.1953535690607833, 'Norepinephrine': 0.2158990832682603, 'Dopamine': 0.3933937786101731, 'Serotonin': 0.1953535690607833}\n",
      "[1] Norepinephrine arg-5 maximized: {'Acetylcholine': 0.1953535690607833, 'Norepinephrine': 0.2158990832682603, 'Dopamine': 0.3933937786101731, 'Serotonin': 0.1953535690607833}\n",
      "[1] Dopamine arg-1 maximized: {'Acetylcholine': 0.20255752969966115, 'Norepinephrine': 0.18698416674945367, 'Dopamine': 0.4079007738512241, 'Serotonin': 0.20255752969966115}\n",
      "[1] Dopamine arg-2 maximized: {'Acetylcholine': 0.2009020680843957, 'Norepinephrine': 0.1854559830715865, 'Dopamine': 0.412739880759622, 'Serotonin': 0.2009020680843957}\n",
      "[1] Dopamine arg-3 maximized: {'Acetylcholine': 0.19757408396712225, 'Norepinephrine': 0.18238386653241628, 'Dopamine': 0.42246796553333926, 'Serotonin': 0.19757408396712225}\n",
      "[1] Dopamine arg-4 maximized: {'Acetylcholine': 0.19924081832947402, 'Norepinephrine': 0.1839224562673875, 'Dopamine': 0.4175959070736644, 'Serotonin': 0.19924081832947402}\n",
      "[1] Dopamine arg-5 maximized: {'Acetylcholine': 0.2009020680843957, 'Norepinephrine': 0.1854559830715865, 'Dopamine': 0.412739880759622, 'Serotonin': 0.2009020680843957}\n",
      "[1] Serotonin arg-1 maximized: {'Acetylcholine': 0.19568016756201603, 'Norepinephrine': 0.18063556134017295, 'Dopamine': 0.3940514672262863, 'Serotonin': 0.22963280387152482}\n",
      "[1] Serotonin arg-2 maximized: {'Acetylcholine': 0.19477662017781835, 'Norepinephrine': 0.17980148198008516, 'Dopamine': 0.3922319462350304, 'Serotonin': 0.23318995160706607}\n",
      "[1] Serotonin arg-3 maximized: {'Acetylcholine': 0.19657399623964392, 'Norepinephrine': 0.18146066920336038, 'Dopamine': 0.3958514171458742, 'Serotonin': 0.2261139174111215}\n",
      "[1] Serotonin arg-4 maximized: {'Acetylcholine': 0.19477662017781838, 'Norepinephrine': 0.1798014819800852, 'Dopamine': 0.39223194623503044, 'Serotonin': 0.23318995160706607}\n",
      "[1] Serotonin arg-5 maximized: {'Acetylcholine': 0.19477662017781838, 'Norepinephrine': 0.1798014819800852, 'Dopamine': 0.39223194623503044, 'Serotonin': 0.23318995160706607}\n",
      "[2] Orig probabily: {'Acetylcholine': 0.24112618633894836, 'Norepinephrine': 0.2664856487282953, 'Dopamine': 0.2560365969838018, 'Serotonin': 0.23635156794895465}\n",
      "[2] Acetylcholine arg-1 maximized: {'Acetylcholine': 0.2795861994544602, 'Norepinephrine': 0.2529800548328606, 'Dopamine': 0.24306056499958809, 'Serotonin': 0.22437318071309115}\n",
      "[2] Acetylcholine arg-2 maximized: {'Acetylcholine': 0.2485211487996322, 'Norepinephrine': 0.2638888383848869, 'Dopamine': 0.25354160903037354, 'Serotonin': 0.2340484037851073}\n",
      "[2] Acetylcholine arg-3 maximized: {'Acetylcholine': 0.24112618633894836, 'Norepinephrine': 0.2664856487282953, 'Dopamine': 0.2560365969838018, 'Serotonin': 0.23635156794895465}\n",
      "[2] Acetylcholine arg-4 maximized: {'Acetylcholine': 0.2485211487996322, 'Norepinephrine': 0.2638888383848869, 'Dopamine': 0.25354160903037354, 'Serotonin': 0.2340484037851073}\n",
      "[2] Acetylcholine arg-5 maximized: {'Acetylcholine': 0.2755756575832382, 'Norepinephrine': 0.2543883941813335, 'Dopamine': 0.24441368257234353, 'Serotonin': 0.22562226566308471}\n",
      "[2] Norepinephrine arg-1 maximized: {'Acetylcholine': 0.23455249147689575, 'Norepinephrine': 0.2864830600232202, 'Dopamine': 0.24905640753343689, 'Serotonin': 0.22990804096644724}\n",
      "[2] Norepinephrine arg-2 maximized: {'Acetylcholine': 0.23455249147689575, 'Norepinephrine': 0.2864830600232202, 'Dopamine': 0.24905640753343689, 'Serotonin': 0.22990804096644724}\n",
      "[2] Norepinephrine arg-3 maximized: {'Acetylcholine': 0.23589063883956612, 'Norepinephrine': 0.28241236861662466, 'Dopamine': 0.25047730130778356, 'Serotonin': 0.23121969123602568}\n",
      "[2] Norepinephrine arg-4 maximized: {'Acetylcholine': 0.23853203462273953, 'Norepinephrine': 0.27437714961464227, 'Dopamine': 0.2532820318842479, 'Serotonin': 0.23380878387837029}\n",
      "[2] Norepinephrine arg-5 maximized: {'Acetylcholine': 0.23853203462273953, 'Norepinephrine': 0.27437714961464227, 'Dopamine': 0.2532820318842479, 'Serotonin': 0.23380878387837029}\n",
      "[2] Dopamine arg-1 maximized: {'Acetylcholine': 0.23480349092552985, 'Norepinephrine': 0.2594979896335349, 'Dopamine': 0.27554444914793613, 'Serotonin': 0.2301540702929991}\n",
      "[2] Dopamine arg-2 maximized: {'Acetylcholine': 0.2373680755227, 'Norepinephrine': 0.26233229394727203, 'Dopamine': 0.2676317578172997, 'Serotonin': 0.23266787271272824}\n",
      "[2] Dopamine arg-3 maximized: {'Acetylcholine': 0.2386327008993231, 'Norepinephrine': 0.26372992113577637, 'Dopamine': 0.2637299211357763, 'Serotonin': 0.23390745682912423}\n",
      "[2] Dopamine arg-4 maximized: {'Acetylcholine': 0.23086976627826164, 'Norepinephrine': 0.2551505515536566, 'Dopamine': 0.287681443555489, 'Serotonin': 0.2262982386125927}\n",
      "[2] Dopamine arg-5 maximized: {'Acetylcholine': 0.2386327008993231, 'Norepinephrine': 0.26372992113577637, 'Dopamine': 0.26372992113577637, 'Serotonin': 0.23390745682912423}\n",
      "[2] Serotonin arg-1 maximized: {'Acetylcholine': 0.23285574454487049, 'Norepinephrine': 0.25734539697784303, 'Dopamine': 0.24725473963077374, 'Serotonin': 0.26254411884651285}\n",
      "[2] Serotonin arg-2 maximized: {'Acetylcholine': 0.23285574454487049, 'Norepinephrine': 0.25734539697784303, 'Dopamine': 0.24725473963077374, 'Serotonin': 0.26254411884651285}\n",
      "[2] Serotonin arg-3 maximized: {'Acetylcholine': 0.23407262300896411, 'Norepinephrine': 0.25869025566719184, 'Dopamine': 0.24854686565665235, 'Serotonin': 0.25869025566719184}\n",
      "[2] Serotonin arg-4 maximized: {'Acetylcholine': 0.23998037164326289, 'Norepinephrine': 0.26521932764912, 'Dopamine': 0.25481992906435424, 'Serotonin': 0.23998037164326289}\n",
      "[2] Serotonin arg-5 maximized: {'Acetylcholine': 0.2376528507757027, 'Norepinephrine': 0.2626470192750783, 'Dopamine': 0.2523484823443318, 'Serotonin': 0.24735164760488723}\n",
      "[3] Orig probabily: {'Acetylcholine': 0.27958619945446017, 'Norepinephrine': 0.22437318071309115, 'Dopamine': 0.24306056499958809, 'Serotonin': 0.2529800548328606}\n",
      "[3] Acetylcholine arg-1 maximized: {'Acetylcholine': 0.27958619945446017, 'Norepinephrine': 0.22437318071309115, 'Dopamine': 0.24306056499958809, 'Serotonin': 0.2529800548328606}\n",
      "[3] Acetylcholine arg-2 maximized: {'Acetylcholine': 0.2918295077204548, 'Norepinephrine': 0.22055999721214786, 'Dopamine': 0.2389297926263447, 'Serotonin': 0.24868070244105261}\n",
      "[3] Acetylcholine arg-3 maximized: {'Acetylcholine': 0.28771348070495983, 'Norepinephrine': 0.2218419355546231, 'Dopamine': 0.24031849985430478, 'Serotonin': 0.2501260838861123}\n",
      "[3] Acetylcholine arg-4 maximized: {'Acetylcholine': 0.3001644014337868, 'Norepinephrine': 0.21796409106494513, 'Dopamine': 0.23611768106818204, 'Serotonin': 0.245753826433086}\n",
      "[3] Acetylcholine arg-5 maximized: {'Acetylcholine': 0.2959799502896294, 'Norepinephrine': 0.21926734013102653, 'Dopamine': 0.2375294739274275, 'Serotonin': 0.24722323565191653}\n",
      "[3] Norepinephrine arg-1 maximized: {'Acetylcholine': 0.2757601752079519, 'Norepinephrine': 0.23498732054769042, 'Dopamine': 0.2397343793120506, 'Serotonin': 0.24951812493230707}\n",
      "[3] Norepinephrine arg-2 maximized: {'Acetylcholine': 0.2757601752079519, 'Norepinephrine': 0.23498732054769042, 'Dopamine': 0.2397343793120506, 'Serotonin': 0.24951812493230707}\n",
      "[3] Norepinephrine arg-3 maximized: {'Acetylcholine': 0.2744573102279914, 'Norepinephrine': 0.23860172291210924, 'Dopamine': 0.23860172291210924, 'Serotonin': 0.24833924394779014}\n",
      "[3] Norepinephrine arg-4 maximized: {'Acetylcholine': 0.26635454695775407, 'Norepinephrine': 0.2610803735572124, 'Dopamine': 0.23155751893364146, 'Serotonin': 0.241007560551392}\n",
      "[3] Norepinephrine arg-5 maximized: {'Acetylcholine': 0.2731407514473281, 'Norepinephrine': 0.2422541145589168, 'Dopamine': 0.23745716169375297, 'Serotonin': 0.24714797230000218}\n",
      "[3] Dopamine arg-1 maximized: {'Acetylcholine': 0.27684008702576585, 'Norepinephrine': 0.22216937386774555, 'Dopamine': 0.2504952695532443, 'Serotonin': 0.25049526955324436}\n",
      "[3] Dopamine arg-2 maximized: {'Acetylcholine': 0.26827218224534405, 'Norepinephrine': 0.21529346922230447, 'Dopamine': 0.273691639818602, 'Serotonin': 0.24274270871374953}\n",
      "[3] Dopamine arg-3 maximized: {'Acetylcholine': 0.27684008702576585, 'Norepinephrine': 0.22216937386774555, 'Dopamine': 0.2504952695532443, 'Serotonin': 0.25049526955324436}\n",
      "[3] Dopamine arg-4 maximized: {'Acetylcholine': 0.27261730967411646, 'Norepinephrine': 0.21878051566343673, 'Dopamine': 0.26192783206500964, 'Serotonin': 0.24667434259743723}\n",
      "[3] Dopamine arg-5 maximized: {'Acetylcholine': 0.2740386160458954, 'Norepinephrine': 0.21992114074445315, 'Dopamine': 0.2580798494245357, 'Serotonin': 0.24796039378511572}\n",
      "[3] Serotonin arg-1 maximized: {'Acetylcholine': 0.2781646290737035, 'Norepinephrine': 0.22323234375990725, 'Dopamine': 0.24182471108187825, 'Serotonin': 0.256778316084511}\n",
      "[3] Serotonin arg-2 maximized: {'Acetylcholine': 0.267829863913933, 'Norepinephrine': 0.21493850044666368, 'Dopamine': 0.23284009787931909, 'Serotonin': 0.28439153776008425}\n",
      "[3] Serotonin arg-3 maximized: {'Acetylcholine': 0.2781646290737035, 'Norepinephrine': 0.22323234375990725, 'Dopamine': 0.24182471108187825, 'Serotonin': 0.256778316084511}\n",
      "[3] Serotonin arg-4 maximized: {'Acetylcholine': 0.2767291612834916, 'Norepinephrine': 0.22208035387439257, 'Dopamine': 0.24057677533680785, 'Serotonin': 0.2606137095053079}\n",
      "[3] Serotonin arg-5 maximized: {'Acetylcholine': 0.2693466436810129, 'Norepinephrine': 0.2161557447221145, 'Dopamine': 0.2341587228611163, 'Serotonin': 0.28033888873575635}\n",
      "[4] Orig probabily: {'Acetylcholine': 0.20108073545602553, 'Norepinephrine': 0.26078765566180034, 'Dopamine': 0.2825078947876985, 'Serotonin': 0.25562371409447565}\n",
      "[4] Acetylcholine arg-1 maximized: {'Acetylcholine': 0.23513250584229844, 'Norepinephrine': 0.2496722879841428, 'Dopamine': 0.27046676073003983, 'Serotonin': 0.2447284454435189}\n",
      "[4] Acetylcholine arg-2 maximized: {'Acetylcholine': 0.22451373272046482, 'Norepinephrine': 0.25313852677865756, 'Dopamine': 0.2742216923896109, 'Serotonin': 0.2481260481112667}\n",
      "[4] Acetylcholine arg-3 maximized: {'Acetylcholine': 0.22451373272046482, 'Norepinephrine': 0.25313852677865756, 'Dopamine': 0.2742216923896109, 'Serotonin': 0.2481260481112667}\n",
      "[4] Acetylcholine arg-4 maximized: {'Acetylcholine': 0.21762625459041937, 'Norepinephrine': 0.2553867755750885, 'Dopamine': 0.2766571912357003, 'Serotonin': 0.2503297785987918}\n",
      "[4] Acetylcholine arg-5 maximized: {'Acetylcholine': 0.22451373272046482, 'Norepinephrine': 0.25313852677865756, 'Dopamine': 0.2742216923896109, 'Serotonin': 0.24812604811126668}\n",
      "[4] Norepinephrine arg-1 maximized: {'Acetylcholine': 0.195712864476538, 'Norepinephrine': 0.2805210054620835, 'Dopamine': 0.27496631738861127, 'Serotonin': 0.24879981267276718}\n",
      "[4] Norepinephrine arg-2 maximized: {'Acetylcholine': 0.19237582677553633, 'Norepinephrine': 0.2927886125827162, 'Dopamine': 0.27027795431096907, 'Serotonin': 0.24455760633077833}\n",
      "[4] Norepinephrine arg-3 maximized: {'Acetylcholine': 0.19896318103889718, 'Norepinephrine': 0.2685722023086942, 'Dopamine': 0.2795328418114667, 'Serotonin': 0.25293177484094187}\n",
      "[4] Norepinephrine arg-4 maximized: {'Acetylcholine': 0.20108073545602553, 'Norepinephrine': 0.26078765566180034, 'Dopamine': 0.2825078947876985, 'Serotonin': 0.25562371409447565}\n",
      "[4] Norepinephrine arg-5 maximized: {'Acetylcholine': 0.19237582677553636, 'Norepinephrine': 0.29278861258271616, 'Dopamine': 0.2702779543109691, 'Serotonin': 0.24455760633077836}\n",
      "[4] Dopamine arg-1 maximized: {'Acetylcholine': 0.19762830482333, 'Norepinephrine': 0.256310094502131, 'Dopamine': 0.2948267860884211, 'Serotonin': 0.25123481458611785}\n",
      "[4] Dopamine arg-2 maximized: {'Acetylcholine': 0.19993967214084293, 'Norepinephrine': 0.2593077763175494, 'Dopamine': 0.2865794132170208, 'Serotonin': 0.2541731383245868}\n",
      "[4] Dopamine arg-3 maximized: {'Acetylcholine': 0.19762830482333, 'Norepinephrine': 0.256310094502131, 'Dopamine': 0.2948267860884211, 'Serotonin': 0.25123481458611785}\n",
      "[4] Dopamine arg-4 maximized: {'Acetylcholine': 0.19046868467905295, 'Norepinephrine': 0.24702456772791972, 'Dopamine': 0.3203735940319457, 'Serotonin': 0.24213315356108164}\n",
      "[4] Dopamine arg-5 maximized: {'Acetylcholine': 0.19762830482333002, 'Norepinephrine': 0.256310094502131, 'Dopamine': 0.2948267860884211, 'Serotonin': 0.2512348145861179}\n",
      "[4] Serotonin arg-1 maximized: {'Acetylcholine': 0.20004770081832207, 'Norepinephrine': 0.25944788195959484, 'Dopamine': 0.28105653526248825, 'Serotonin': 0.25944788195959484}\n",
      "[4] Serotonin arg-2 maximized: {'Acetylcholine': 0.19364224986796744, 'Norepinephrine': 0.2511404599034181, 'Dopamine': 0.27205721238331426, 'Serotonin': 0.28316007784530034}\n",
      "[4] Serotonin arg-3 maximized: {'Acetylcholine': 0.19030999019743444, 'Norepinephrine': 0.24681875208012086, 'Dopamine': 0.2673755621880667, 'Serotonin': 0.2954956955343781}\n",
      "[4] Serotonin arg-4 maximized: {'Acetylcholine': 0.20004770081832207, 'Norepinephrine': 0.25944788195959484, 'Dopamine': 0.28105653526248825, 'Serotonin': 0.25944788195959484}\n",
      "[4] Serotonin arg-5 maximized: {'Acetylcholine': 0.19581637270941418, 'Norepinephrine': 0.2539601452285976, 'Dopamine': 0.2751117410309941, 'Serotonin': 0.2751117410309942}\n",
      "[5] Orig probabily: {'Acetylcholine': 0.22874519351044031, 'Norepinephrine': 0.2793900102695336, 'Dopamine': 0.22874519351044031, 'Serotonin': 0.2631196027095858}\n",
      "[5] Acetylcholine arg-1 maximized: {'Acetylcholine': 0.23587847308493595, 'Norepinephrine': 0.27680595239812145, 'Dopamine': 0.22662954586338196, 'Serotonin': 0.2606860286535606}\n",
      "[5] Acetylcholine arg-2 maximized: {'Acetylcholine': 0.25060088802645764, 'Norepinephrine': 0.27147270114692196, 'Dopamine': 0.2222630490501333, 'Serotonin': 0.2556633617764871}\n",
      "[5] Acetylcholine arg-3 maximized: {'Acetylcholine': 0.25060088802645764, 'Norepinephrine': 0.27147270114692196, 'Dopamine': 0.2222630490501333, 'Serotonin': 0.2556633617764871}\n",
      "[5] Acetylcholine arg-4 maximized: {'Acetylcholine': 0.2581875642267646, 'Norepinephrine': 0.2687243986097058, 'Dopamine': 0.22001292924415222, 'Serotonin': 0.2530751079193773}\n",
      "[5] Acetylcholine arg-5 maximized: {'Acetylcholine': 0.24686365220710993, 'Norepinephrine': 0.27282652914923905, 'Dopamine': 0.22337146967000845, 'Serotonin': 0.25693834897364254}\n",
      "[5] Norepinephrine arg-1 maximized: {'Acetylcholine': 0.2248603899756663, 'Norepinephrine': 0.2916282050588402, 'Dopamine': 0.2248603899756663, 'Serotonin': 0.25865101498982723}\n",
      "[5] Norepinephrine arg-2 maximized: {'Acetylcholine': 0.2274613894643952, 'Norepinephrine': 0.2834343445186565, 'Dopamine': 0.2274613894643952, 'Serotonin': 0.2616428765525532}\n",
      "[5] Norepinephrine arg-3 maximized: {'Acetylcholine': 0.22087724847068751, 'Norepinephrine': 0.3041761913791156, 'Dopamine': 0.22087724847068751, 'Serotonin': 0.2540693116795094}\n",
      "[5] Norepinephrine arg-4 maximized: {'Acetylcholine': 0.22087724847068751, 'Norepinephrine': 0.3041761913791156, 'Dopamine': 0.22087724847068751, 'Serotonin': 0.2540693116795094}\n",
      "[5] Norepinephrine arg-5 maximized: {'Acetylcholine': 0.2274613894643952, 'Norepinephrine': 0.2834343445186565, 'Dopamine': 0.2274613894643952, 'Serotonin': 0.2616428765525532}\n",
      "[5] Dopamine arg-1 maximized: {'Acetylcholine': 0.22662954586338196, 'Norepinephrine': 0.27680595239812145, 'Dopamine': 0.23587847308493595, 'Serotonin': 0.2606860286535606}\n",
      "[5] Dopamine arg-2 maximized: {'Acetylcholine': 0.2177188616568317, 'Norepinephrine': 0.2659224181311467, 'Dopamine': 0.2659224181311467, 'Serotonin': 0.2504363020808749}\n",
      "[5] Dopamine arg-3 maximized: {'Acetylcholine': 0.2211435158063743, 'Norepinephrine': 0.2701053001551427, 'Dopamine': 0.2543755920192415, 'Serotonin': 0.2543755920192415}\n",
      "[5] Dopamine arg-4 maximized: {'Acetylcholine': 0.22662954586338196, 'Norepinephrine': 0.27680595239812145, 'Dopamine': 0.23587847308493595, 'Serotonin': 0.2606860286535606}\n",
      "[5] Dopamine arg-5 maximized: {'Acetylcholine': 0.2222630490501333, 'Norepinephrine': 0.27147270114692196, 'Dopamine': 0.25060088802645764, 'Serotonin': 0.2556633617764871}\n",
      "[5] Serotonin arg-1 maximized: {'Acetylcholine': 0.22874519351044031, 'Norepinephrine': 0.2793900102695336, 'Dopamine': 0.22874519351044031, 'Serotonin': 0.2631196027095858}\n",
      "[5] Serotonin arg-2 maximized: {'Acetylcholine': 0.2174607725463547, 'Norepinephrine': 0.265607187379759, 'Dopamine': 0.2174607725463547, 'Serotonin': 0.2994712675275315}\n",
      "[5] Serotonin arg-3 maximized: {'Acetylcholine': 0.22258568443999033, 'Norepinephrine': 0.2718667689019734, 'Dopamine': 0.22258568443999033, 'Serotonin': 0.28296186221804603}\n",
      "[5] Serotonin arg-4 maximized: {'Acetylcholine': 0.22508300134376102, 'Norepinephrine': 0.2749169986562389, 'Dopamine': 0.22508300134376102, 'Serotonin': 0.2749169986562389}\n",
      "[5] Serotonin arg-5 maximized: {'Acetylcholine': 0.22508300134376102, 'Norepinephrine': 0.2749169986562389, 'Dopamine': 0.22508300134376102, 'Serotonin': 0.2749169986562389}\n",
      "[6] Orig probabily: {'Acetylcholine': 0.2649633412878029, 'Norepinephrine': 0.24953307752483184, 'Dopamine': 0.25971671560522946, 'Serotonin': 0.2257868655821358}\n",
      "[6] Acetylcholine arg-1 maximized: {'Acetylcholine': 0.2931096290162451, 'Norepinephrine': 0.2399778672988782, 'Dopamine': 0.24977154985238367, 'Serotonin': 0.2171409538324931}\n",
      "[6] Acetylcholine arg-2 maximized: {'Acetylcholine': 0.28898291463397985, 'Norepinephrine': 0.2413788202005699, 'Dopamine': 0.25122967672660046, 'Serotonin': 0.2184085884388498}\n",
      "[6] Acetylcholine arg-3 maximized: {'Acetylcholine': 0.27681235002752336, 'Norepinephrine': 0.24551053037511372, 'Dopamine': 0.255530005192106, 'Serotonin': 0.22214711440525695}\n",
      "[6] Acetylcholine arg-4 maximized: {'Acetylcholine': 0.2808339126967506, 'Norepinephrine': 0.2441452747821894, 'Dopamine': 0.25410903246146394, 'Serotonin': 0.22091178005959614}\n",
      "[6] Acetylcholine arg-5 maximized: {'Acetylcholine': 0.2768123500275234, 'Norepinephrine': 0.24551053037511372, 'Dopamine': 0.255530005192106, 'Serotonin': 0.22214711440525695}\n",
      "[6] Norepinephrine arg-1 maximized: {'Acetylcholine': 0.2553867755750885, 'Norepinephrine': 0.2766571912357004, 'Dopamine': 0.25032977859879185, 'Serotonin': 0.2176262545904194}\n",
      "[6] Norepinephrine arg-2 maximized: {'Acetylcholine': 0.2609370143311511, 'Norepinephrine': 0.2609370143311511, 'Dopamine': 0.2557701152640201, 'Serotonin': 0.2223558560736777}\n",
      "[6] Norepinephrine arg-3 maximized: {'Acetylcholine': 0.2609370143311511, 'Norepinephrine': 0.2609370143311511, 'Dopamine': 0.2557701152640201, 'Serotonin': 0.2223558560736777}\n",
      "[6] Norepinephrine arg-4 maximized: {'Acetylcholine': 0.25679353664418375, 'Norepinephrine': 0.27267276212542935, 'Dopamine': 0.2517086839323786, 'Serotonin': 0.21882501729800838}\n",
      "[6] Norepinephrine arg-5 maximized: {'Acetylcholine': 0.2553867755750885, 'Norepinephrine': 0.2766571912357003, 'Dopamine': 0.25032977859879185, 'Serotonin': 0.2176262545904194}\n",
      "[6] Dopamine arg-1 maximized: {'Acetylcholine': 0.2649633412878029, 'Norepinephrine': 0.24953307752483184, 'Dopamine': 0.25971671560522946, 'Serotonin': 0.2257868655821358}\n",
      "[6] Dopamine arg-2 maximized: {'Acetylcholine': 0.25791839186672005, 'Norepinephrine': 0.24289839401916108, 'Dopamine': 0.27939965842474007, 'Serotonin': 0.21978355568937888}\n",
      "[6] Dopamine arg-3 maximized: {'Acetylcholine': 0.2520530226873153, 'Norepinephrine': 0.23737459734961952, 'Dopamine': 0.29578696218990985, 'Serotonin': 0.21478541777315527}\n",
      "[6] Dopamine arg-4 maximized: {'Acetylcholine': 0.2635804334164165, 'Norepinephrine': 0.24823070393834562, 'Dopamine': 0.2635804334164165, 'Serotonin': 0.22460842922882135}\n",
      "[6] Dopamine arg-5 maximized: {'Acetylcholine': 0.2520530226873153, 'Norepinephrine': 0.23737459734961952, 'Dopamine': 0.2957869621899099, 'Serotonin': 0.21478541777315527}\n",
      "[6] Serotonin arg-1 maximized: {'Acetylcholine': 0.2588174082568759, 'Norepinephrine': 0.24374505577052077, 'Dopamine': 0.2536924802020826, 'Serotonin': 0.24374505577052077}\n",
      "[6] Serotonin arg-2 maximized: {'Acetylcholine': 0.2575492417780046, 'Norepinephrine': 0.2425507415580394, 'Dopamine': 0.2524494251019609, 'Serotonin': 0.24745059156199511}\n",
      "[6] Serotonin arg-3 maximized: {'Acetylcholine': 0.2588174082568759, 'Norepinephrine': 0.24374505577052077, 'Dopamine': 0.2536924802020826, 'Serotonin': 0.24374505577052077}\n",
      "[6] Serotonin arg-4 maximized: {'Acetylcholine': 0.25497434505325567, 'Norepinephrine': 0.2401257951450286, 'Dopamine': 0.24992551474846006, 'Serotonin': 0.25497434505325567}\n",
      "[6] Serotonin arg-5 maximized: {'Acetylcholine': 0.25626819970608716, 'Norepinephrine': 0.24134430156867828, 'Dopamine': 0.2511937493626173, 'Serotonin': 0.25119374936261724}\n",
      "[7] Orig probabily: {'Acetylcholine': 0.2354893386456349, 'Norepinephrine': 0.2934377851877373, 'Dopamine': 0.23082633731833654, 'Serotonin': 0.24024653884829122}\n",
      "[7] Acetylcholine arg-1 maximized: {'Acetylcholine': 0.24646224054668187, 'Norepinephrine': 0.28922611857052966, 'Dopamine': 0.22751332301571708, 'Serotonin': 0.2367983178670714}\n",
      "[7] Acetylcholine arg-2 maximized: {'Acetylcholine': 0.2694193916778317, 'Norepinephrine': 0.28041460563464626, 'Dopamine': 0.2205819414422029, 'Serotonin': 0.22958406124531922}\n",
      "[7] Acetylcholine arg-3 maximized: {'Acetylcholine': 0.2539660845539582, 'Norepinephrine': 0.2863459607425294, 'Dopamine': 0.22524771062394314, 'Serotonin': 0.2344402440795693}\n",
      "[7] Acetylcholine arg-4 maximized: {'Acetylcholine': 0.23910904923083334, 'Norepinephrine': 0.2920484522315957, 'Dopamine': 0.2297334493067376, 'Serotonin': 0.23910904923083334}\n",
      "[7] Acetylcholine arg-5 maximized: {'Acetylcholine': 0.26550094100546207, 'Norepinephrine': 0.2819186023017831, 'Dopamine': 0.22176502712352394, 'Serotonin': 0.23081542956923093}\n",
      "[7] Norepinephrine arg-1 maximized: {'Acetylcholine': 0.22843944134430721, 'Norepinephrine': 0.3145902971446408, 'Dopamine': 0.22391603733662627, 'Serotonin': 0.2330542241744257}\n",
      "[7] Norepinephrine arg-2 maximized: {'Acetylcholine': 0.2354893386456349, 'Norepinephrine': 0.2934377851877373, 'Dopamine': 0.23082633731833654, 'Serotonin': 0.24024653884829122}\n",
      "[7] Norepinephrine arg-3 maximized: {'Acetylcholine': 0.22987138034029173, 'Norepinephrine': 0.3102939073619961, 'Dopamine': 0.22531962204074651, 'Serotonin': 0.23451509025696568}\n",
      "[7] Norepinephrine arg-4 maximized: {'Acetylcholine': 0.22843944134430721, 'Norepinephrine': 0.3145902971446408, 'Dopamine': 0.22391603733662627, 'Serotonin': 0.2330542241744257}\n",
      "[7] Norepinephrine arg-5 maximized: {'Acetylcholine': 0.23410162250880603, 'Norepinephrine': 0.29760148870318187, 'Dopamine': 0.2294660998020905, 'Serotonin': 0.23883078898592164}\n",
      "[7] Dopamine arg-1 maximized: {'Acetylcholine': 0.2299080409664472, 'Norepinephrine': 0.28648306002322016, 'Dopamine': 0.24905640753343686, 'Serotonin': 0.23455249147689572}\n",
      "[7] Dopamine arg-2 maximized: {'Acetylcholine': 0.22875710149821996, 'Norepinephrine': 0.2850489011335476, 'Dopamine': 0.25281569587911185, 'Serotonin': 0.2333783014891206}\n",
      "[7] Dopamine arg-3 maximized: {'Acetylcholine': 0.2354893386456349, 'Norepinephrine': 0.2934377851877373, 'Dopamine': 0.23082633731833654, 'Serotonin': 0.24024653884829122}\n",
      "[7] Dopamine arg-4 maximized: {'Acetylcholine': 0.22642097943246714, 'Norepinephrine': 0.2821379137876012, 'Dopamine': 0.2604461201527581, 'Serotonin': 0.2309949866271735}\n",
      "[7] Dopamine arg-5 maximized: {'Acetylcholine': 0.22642097943246714, 'Norepinephrine': 0.2821379137876012, 'Dopamine': 0.2604461201527581, 'Serotonin': 0.2309949866271735}\n",
      "[7] Serotonin arg-1 maximized: {'Acetylcholine': 0.2354893386456349, 'Norepinephrine': 0.2934377851877373, 'Dopamine': 0.23082633731833654, 'Serotonin': 0.24024653884829122}\n",
      "[7] Serotonin arg-2 maximized: {'Acetylcholine': 0.22849051928202693, 'Norepinephrine': 0.284716719237161, 'Dopamine': 0.2239661038634144, 'Serotonin': 0.26282665761739765}\n",
      "[7] Serotonin arg-3 maximized: {'Acetylcholine': 0.22849051928202693, 'Norepinephrine': 0.284716719237161, 'Dopamine': 0.2239661038634144, 'Serotonin': 0.26282665761739765}\n",
      "[7] Serotonin arg-4 maximized: {'Acetylcholine': 0.22606570252732483, 'Norepinephrine': 0.2816952115031883, 'Dopamine': 0.2215893016974434, 'Serotonin': 0.2706497842720434}\n",
      "[7] Serotonin arg-5 maximized: {'Acetylcholine': 0.22968587728556808, 'Norepinephrine': 0.286206227030095, 'Dopamine': 0.225137792192612, 'Serotonin': 0.25897010349172483}\n",
      "[8] Orig probabily: {'Acetylcholine': 0.2355115235662887, 'Norepinephrine': 0.2934654293011339, 'Dopamine': 0.2355115235662887, 'Serotonin': 0.23551152356628868}\n",
      "[8] Acetylcholine arg-1 maximized: {'Acetylcholine': 0.2539894318392161, 'Norepinephrine': 0.28637228473315063, 'Dopamine': 0.22981914171381665, 'Serotonin': 0.22981914171381662}\n",
      "[8] Acetylcholine arg-2 maximized: {'Acetylcholine': 0.23913146849330813, 'Norepinephrine': 0.2920758351806183, 'Dopamine': 0.23439634816303678, 'Serotonin': 0.23439634816303676}\n",
      "[8] Acetylcholine arg-3 maximized: {'Acetylcholine': 0.24648512591509186, 'Norepinephrine': 0.28925297479914547, 'Dopamine': 0.23213094964288133, 'Serotonin': 0.23213094964288128}\n",
      "[8] Acetylcholine arg-4 maximized: {'Acetylcholine': 0.2655249712829531, 'Norepinephrine': 0.2819441185286467, 'Dopamine': 0.22626545509420012, 'Serotonin': 0.2262654550942001}\n",
      "[8] Acetylcholine arg-5 maximized: {'Acetylcholine': 0.2655249712829531, 'Norepinephrine': 0.2819441185286467, 'Dopamine': 0.22626545509420012, 'Serotonin': 0.2262654550942001}\n",
      "[8] Norepinephrine arg-1 maximized: {'Acetylcholine': 0.22556410915816674, 'Norepinephrine': 0.3233076725254998, 'Dopamine': 0.22556410915816674, 'Serotonin': 0.22556410915816671}\n",
      "[8] Norepinephrine arg-2 maximized: {'Acetylcholine': 0.2355115235662887, 'Norepinephrine': 0.2934654293011339, 'Dopamine': 0.2355115235662887, 'Serotonin': 0.23551152356628868}\n",
      "[8] Norepinephrine arg-3 maximized: {'Acetylcholine': 0.23412354672046037, 'Norepinephrine': 0.29762935983861893, 'Dopamine': 0.23412354672046037, 'Serotonin': 0.23412354672046035}\n",
      "[8] Norepinephrine arg-4 maximized: {'Acetylcholine': 0.2284603177791196, 'Norepinephrine': 0.3146190466626413, 'Dopamine': 0.2284603177791196, 'Serotonin': 0.22846031777911957}\n",
      "[8] Norepinephrine arg-5 maximized: {'Acetylcholine': 0.2341235467204604, 'Norepinephrine': 0.2976293598386189, 'Dopamine': 0.2341235467204604, 'Serotonin': 0.23412354672046037}\n",
      "[8] Dopamine arg-1 maximized: {'Acetylcholine': 0.2286459759308725, 'Norepinephrine': 0.2849104301499026, 'Dopamine': 0.25779761798835243, 'Serotonin': 0.22864597593087246}\n",
      "[8] Dopamine arg-2 maximized: {'Acetylcholine': 0.2332694755542397, 'Norepinephrine': 0.29067166544446, 'Dopamine': 0.24278938344706058, 'Serotonin': 0.23326947555423969}\n",
      "[8] Dopamine arg-3 maximized: {'Acetylcholine': 0.22383986373496437, 'Norepinephrine': 0.2789216455779892, 'Dopamine': 0.273398626952082, 'Serotonin': 0.22383986373496434}\n",
      "[8] Dopamine arg-4 maximized: {'Acetylcholine': 0.2286459759308725, 'Norepinephrine': 0.2849104301499026, 'Dopamine': 0.25779761798835243, 'Serotonin': 0.22864597593087246}\n",
      "[8] Dopamine arg-5 maximized: {'Acetylcholine': 0.23439634816303678, 'Norepinephrine': 0.2920758351806183, 'Dopamine': 0.2391314684933081, 'Serotonin': 0.23439634816303676}\n",
      "[8] Serotonin arg-1 maximized: {'Acetylcholine': 0.23213094964288133, 'Norepinephrine': 0.28925297479914547, 'Dopamine': 0.23213094964288133, 'Serotonin': 0.24648512591509186}\n",
      "[8] Serotonin arg-2 maximized: {'Acetylcholine': 0.2355115235662887, 'Norepinephrine': 0.2934654293011339, 'Dopamine': 0.2355115235662887, 'Serotonin': 0.23551152356628868}\n",
      "[8] Serotonin arg-3 maximized: {'Acetylcholine': 0.22746138946439518, 'Norepinephrine': 0.28343434451865646, 'Dopamine': 0.22746138946439518, 'Serotonin': 0.26164287655255314}\n",
      "[8] Serotonin arg-4 maximized: {'Acetylcholine': 0.2238398637349644, 'Norepinephrine': 0.27892164557798926, 'Dopamine': 0.2238398637349644, 'Serotonin': 0.27339862695208206}\n",
      "[8] Serotonin arg-5 maximized: {'Acetylcholine': 0.22981914171381665, 'Norepinephrine': 0.28637228473315063, 'Dopamine': 0.22981914171381665, 'Serotonin': 0.2539894318392161}\n",
      "[9] Orig probabily: {'Acetylcholine': 0.29611789798519716, 'Norepinephrine': 0.2238010928512571, 'Dopamine': 0.24244082961728947, 'Serotonin': 0.23764017954625627}\n",
      "[9] Acetylcholine arg-1 maximized: {'Acetylcholine': 0.31305976179077827, 'Norepinephrine': 0.21841438444686231, 'Dopamine': 0.23660547806547258, 'Serotonin': 0.2319203756968868}\n",
      "[9] Acetylcholine arg-2 maximized: {'Acetylcholine': 0.3349561847991908, 'Norepinephrine': 0.21145236142512472, 'Dopamine': 0.2290636085611689, 'Serotonin': 0.2245278452145157}\n",
      "[9] Acetylcholine arg-3 maximized: {'Acetylcholine': 0.30030346749088327, 'Norepinephrine': 0.2224702804511462, 'Dopamine': 0.24099917775474786, 'Serotonin': 0.23622707430322276}\n",
      "[9] Acetylcholine arg-4 maximized: {'Acetylcholine': 0.30030346749088327, 'Norepinephrine': 0.2224702804511462, 'Dopamine': 0.24099917775474786, 'Serotonin': 0.23622707430322276}\n",
      "[9] Acetylcholine arg-5 maximized: {'Acetylcholine': 0.30452260368940487, 'Norepinephrine': 0.22112879543623448, 'Dopamine': 0.2395459643866142, 'Serotonin': 0.23480263648774652}\n",
      "[9] Norepinephrine arg-1 maximized: {'Acetylcholine': 0.28930834154719065, 'Norepinephrine': 0.2416506396071664, 'Dopamine': 0.23686563634667337, 'Serotonin': 0.2321753824989696}\n",
      "[9] Norepinephrine arg-2 maximized: {'Acetylcholine': 0.28360049220848565, 'Norepinephrine': 0.25661233712365344, 'Dopamine': 0.23219244455913976, 'Serotonin': 0.22759472610872114}\n",
      "[9] Norepinephrine arg-3 maximized: {'Acetylcholine': 0.2920758351806183, 'Norepinephrine': 0.2343963481630368, 'Dopamine': 0.23913146849330813, 'Serotonin': 0.2343963481630368}\n",
      "[9] Norepinephrine arg-4 maximized: {'Acetylcholine': 0.28360049220848565, 'Norepinephrine': 0.25661233712365344, 'Dopamine': 0.23219244455913976, 'Serotonin': 0.22759472610872114}\n",
      "[9] Norepinephrine arg-5 maximized: {'Acetylcholine': 0.28930834154719065, 'Norepinephrine': 0.2416506396071664, 'Dopamine': 0.23686563634667337, 'Serotonin': 0.2321753824989696}\n",
      "[9] Dopamine arg-1 maximized: {'Acetylcholine': 0.2932167533842166, 'Norepinephrine': 0.22160845493022394, 'Dopamine': 0.24986283521719746, 'Serotonin': 0.23531195646836198}\n",
      "[9] Dopamine arg-2 maximized: {'Acetylcholine': 0.29025697521666316, 'Norepinephrine': 0.21937150271287142, 'Dopamine': 0.25743484321936405, 'Serotonin': 0.23293667885110142}\n",
      "[9] Dopamine arg-3 maximized: {'Acetylcholine': 0.2872392070018942, 'Norepinephrine': 0.21709072256066717, 'Dopamine': 0.2651552073065831, 'Serotonin': 0.23051486313085565}\n",
      "[9] Dopamine arg-4 maximized: {'Acetylcholine': 0.28570881047207275, 'Norepinephrine': 0.21593407374544787, 'Dopamine': 0.2690704246351421, 'Serotonin': 0.2292866911473374}\n",
      "[9] Dopamine arg-5 maximized: {'Acetylcholine': 0.28416421227108846, 'Norepinephrine': 0.2147666915380622, 'Dopamine': 0.2730219741351008, 'Serotonin': 0.2280471220557485}\n",
      "[9] Serotonin arg-1 maximized: {'Acetylcholine': 0.29327364811522977, 'Norepinephrine': 0.22165145504289818, 'Dopamine': 0.24011215477930908, 'Serotonin': 0.24496274206256294}\n",
      "[9] Serotonin arg-2 maximized: {'Acetylcholine': 0.2888975294528007, 'Norepinephrine': 0.21834405570715334, 'Dopamine': 0.23652929185125998, 'Serotonin': 0.25622912298878586}\n",
      "[9] Serotonin arg-3 maximized: {'Acetylcholine': 0.2813166499753098, 'Norepinephrine': 0.21261455025213033, 'Dopamine': 0.2303225926876604, 'Serotonin': 0.2757462070848995}\n",
      "[9] Serotonin arg-4 maximized: {'Acetylcholine': 0.2813166499753098, 'Norepinephrine': 0.21261455025213033, 'Dopamine': 0.2303225926876604, 'Serotonin': 0.2757462070848995}\n",
      "[9] Serotonin arg-5 maximized: {'Acetylcholine': 0.2947031313766203, 'Norepinephrine': 0.22273183525054024, 'Dopamine': 0.24128251668641973, 'Serotonin': 0.24128251668641973}\n",
      "[10] Orig probabily: {'Acetylcholine': 0.21009354481702955, 'Norepinephrine': 0.20185565909427733, 'Dopamine': 0.24166509991206575, 'Serotonin': 0.34638569617662734}\n",
      "[10] Acetylcholine arg-1 maximized: {'Acetylcholine': 0.22367769102509003, 'Norepinephrine': 0.19838431540785828, 'Dopamine': 0.2375091469773216, 'Serotonin': 0.34042884658973016}\n",
      "[10] Acetylcholine arg-2 maximized: {'Acetylcholine': 0.23787565525071375, 'Norepinephrine': 0.19475611436233525, 'Dopamine': 0.2331654016887247, 'Serotonin': 0.3342028286982264}\n",
      "[10] Acetylcholine arg-3 maximized: {'Acetylcholine': 0.23070021315750291, 'Norepinephrine': 0.19658975375534712, 'Dopamine': 0.23536066660774269, 'Serotonin': 0.3373493664794072}\n",
      "[10] Acetylcholine arg-4 maximized: {'Acetylcholine': 0.24152045814730913, 'Norepinephrine': 0.1938247077557256, 'Dopamine': 0.2320503055271653, 'Serotonin': 0.33260452856979994}\n",
      "[10] Acetylcholine arg-5 maximized: {'Acetylcholine': 0.23070021315750291, 'Norepinephrine': 0.19658975375534712, 'Dopamine': 0.23536066660774269, 'Serotonin': 0.3373493664794072}\n",
      "[10] Norepinephrine arg-1 maximized: {'Acetylcholine': 0.20482224744325891, 'Norepinephrine': 0.22188129182740274, 'Dopamine': 0.23560166465703244, 'Serotonin': 0.33769479607230596}\n",
      "[10] Norepinephrine arg-2 maximized: {'Acetylcholine': 0.20572611416681272, 'Norepinephrine': 0.21844750660108483, 'Dopamine': 0.23664135886679533, 'Serotonin': 0.3391850203653072}\n",
      "[10] Norepinephrine arg-3 maximized: {'Acetylcholine': 0.2029841956524028, 'Norepinephrine': 0.22886404151845618, 'Dopamine': 0.23348740184106806, 'Serotonin': 0.334664360988073}\n",
      "[10] Norepinephrine arg-4 maximized: {'Acetylcholine': 0.20482224744325891, 'Norepinephrine': 0.22188129182740274, 'Dopamine': 0.23560166465703244, 'Serotonin': 0.33769479607230596}\n",
      "[10] Norepinephrine arg-5 maximized: {'Acetylcholine': 0.20110584320178, 'Norepinephrine': 0.23599989321726325, 'Dopamine': 0.23132678223209735, 'Serotonin': 0.33156748134885944}\n",
      "[10] Dopamine arg-1 maximized: {'Acetylcholine': 0.20053589310236752, 'Norepinephrine': 0.19267276826373397, 'Dopamine': 0.2761635461371779, 'Serotonin': 0.3306277924967205}\n",
      "[10] Dopamine arg-2 maximized: {'Acetylcholine': 0.20594830435376058, 'Norepinephrine': 0.1978729558344216, 'Dopamine': 0.25662738975914884, 'Serotonin': 0.3395513500526689}\n",
      "[10] Dopamine arg-3 maximized: {'Acetylcholine': 0.20053589310236752, 'Norepinephrine': 0.19267276826373397, 'Dopamine': 0.2761635461371779, 'Serotonin': 0.3306277924967205}\n",
      "[10] Dopamine arg-4 maximized: {'Acetylcholine': 0.20907285971799602, 'Norepinephrine': 0.20087499563042577, 'Dopamine': 0.24534927370841408, 'Serotonin': 0.3447028709431641}\n",
      "[10] Dopamine arg-5 maximized: {'Acetylcholine': 0.20700018880929938, 'Norepinephrine': 0.19888359531051178, 'Dopamine': 0.25283060155135423, 'Serotonin': 0.3412856143288346}\n",
      "[10] Serotonin arg-1 maximized: {'Acetylcholine': 0.20863364026007383, 'Norepinephrine': 0.20045299821378393, 'Dopamine': 0.23998580995136728, 'Serotonin': 0.350927551574775}\n",
      "[10] Serotonin arg-2 maximized: {'Acetylcholine': 0.21009354481702955, 'Norepinephrine': 0.20185565909427733, 'Dopamine': 0.24166509991206575, 'Serotonin': 0.34638569617662734}\n",
      "[10] Serotonin arg-3 maximized: {'Acetylcholine': 0.20863364026007383, 'Norepinephrine': 0.20045299821378393, 'Dopamine': 0.23998580995136728, 'Serotonin': 0.350927551574775}\n",
      "[10] Serotonin arg-4 maximized: {'Acetylcholine': 0.21009354481702955, 'Norepinephrine': 0.20185565909427733, 'Dopamine': 0.24166509991206575, 'Serotonin': 0.34638569617662734}\n",
      "[10] Serotonin arg-5 maximized: {'Acetylcholine': 0.20120759649079212, 'Norepinephrine': 0.19331813378557514, 'Dopamine': 0.2314438263743956, 'Serotonin': 0.37403044334923713}\n",
      "[11] Orig probabily: {'Acetylcholine': 0.236932807153654, 'Norepinephrine': 0.2952364577069156, 'Dopamine': 0.26185124800424414, 'Serotonin': 0.20597948713518618}\n",
      "[11] Acetylcholine arg-1 maximized: {'Acetylcholine': 0.26316757318952894, 'Norepinephrine': 0.2850860286676199, 'Dopamine': 0.2528486250478455, 'Serotonin': 0.19889777309500564}\n",
      "[11] Acetylcholine arg-2 maximized: {'Acetylcholine': 0.25548496111254587, 'Norepinephrine': 0.2880584892802747, 'Dopamine': 0.25548496111254587, 'Serotonin': 0.2009715884946335}\n",
      "[11] Acetylcholine arg-3 maximized: {'Acetylcholine': 0.26316757318952894, 'Norepinephrine': 0.2850860286676199, 'Dopamine': 0.2528486250478455, 'Serotonin': 0.19889777309500564}\n",
      "[11] Acetylcholine arg-4 maximized: {'Acetylcholine': 0.24424055605460973, 'Norepinephrine': 0.2924090344871046, 'Dopamine': 0.25934354856734515, 'Serotonin': 0.2040068608909405}\n",
      "[11] Acetylcholine arg-5 maximized: {'Acetylcholine': 0.2670641078533389, 'Norepinephrine': 0.2835784299892069, 'Dopamine': 0.25151150496959324, 'Serotonin': 0.1978459571878609}\n",
      "[11] Norepinephrine arg-1 maximized: {'Acetylcholine': 0.23124659697671657, 'Norepinephrine': 0.31215025565099913, 'Dopamine': 0.25556701388262715, 'Serotonin': 0.20103613348965713}\n",
      "[11] Norepinephrine arg-2 maximized: {'Acetylcholine': 0.2326848193295592, 'Norepinephrine': 0.3078722213332901, 'Dopamine': 0.2571564954007151, 'Serotonin': 0.2022864639364355}\n",
      "[11] Norepinephrine arg-3 maximized: {'Acetylcholine': 0.23411203145817017, 'Norepinephrine': 0.30362693724854456, 'Dopamine': 0.2587338087391808, 'Serotonin': 0.2035272225541045}\n",
      "[11] Norepinephrine arg-4 maximized: {'Acetylcholine': 0.23411203145817017, 'Norepinephrine': 0.30362693724854456, 'Dopamine': 0.2587338087391808, 'Serotonin': 0.2035272225541045}\n",
      "[11] Norepinephrine arg-5 maximized: {'Acetylcholine': 0.22686753319443312, 'Norepinephrine': 0.32517590853632533, 'Dopamine': 0.2507273999420491, 'Serotonin': 0.19722915832719234}\n",
      "[11] Dopamine arg-1 maximized: {'Acetylcholine': 0.23442763093478747, 'Norepinephrine': 0.2921148159145651, 'Dopamine': 0.269655961592458, 'Serotonin': 0.2038015915581893}\n",
      "[11] Dopamine arg-2 maximized: {'Acetylcholine': 0.22529805239829895, 'Norepinephrine': 0.28073866054017677, 'Dopamine': 0.2980985697897513, 'Serotonin': 0.19586471727177285}\n",
      "[11] Dopamine arg-3 maximized: {'Acetylcholine': 0.2331575258839367, 'Norepinephrine': 0.29053216756529854, 'Dopamine': 0.2736128912783541, 'Serotonin': 0.20269741527241059}\n",
      "[11] Dopamine arg-4 maximized: {'Acetylcholine': 0.22394943103648243, 'Norepinephrine': 0.2790581748428442, 'Dopamine': 0.30230011193623046, 'Serotonin': 0.1946922821844429}\n",
      "[11] Dopamine arg-5 maximized: {'Acetylcholine': 0.236932807153654, 'Norepinephrine': 0.2952364577069156, 'Dopamine': 0.26185124800424414, 'Serotonin': 0.20597948713518618}\n",
      "[11] Serotonin arg-1 maximized: {'Acetylcholine': 0.22875710149821996, 'Norepinephrine': 0.2850489011335476, 'Dopamine': 0.25281569587911185, 'Serotonin': 0.23337830148912056}\n",
      "[11] Serotonin arg-2 maximized: {'Acetylcholine': 0.22659889450687887, 'Norepinephrine': 0.2823596096218465, 'Dopamine': 0.2504305082770941, 'Serotonin': 0.2406109875941805}\n",
      "[11] Serotonin arg-3 maximized: {'Acetylcholine': 0.2329366788511014, 'Norepinephrine': 0.29025697521666316, 'Dopamine': 0.257434843219364, 'Serotonin': 0.21937150271287142}\n",
      "[11] Serotonin arg-4 maximized: {'Acetylcholine': 0.22875710149821996, 'Norepinephrine': 0.2850489011335476, 'Dopamine': 0.25281569587911185, 'Serotonin': 0.23337830148912056}\n",
      "[11] Serotonin arg-5 maximized: {'Acetylcholine': 0.23086976627826164, 'Norepinephrine': 0.287681443555489, 'Dopamine': 0.25515055155365657, 'Serotonin': 0.2262982386125927}\n",
      "[12] Orig probabily: {'Acetylcholine': 0.24325232579184894, 'Norepinephrine': 0.22455019823502323, 'Dopamine': 0.22908641314264433, 'Serotonin': 0.3031110628304835}\n",
      "[12] Acetylcholine arg-1 maximized: {'Acetylcholine': 0.2621293232807917, 'Norepinephrine': 0.21894881527384058, 'Dopamine': 0.22337187473964273, 'Serotonin': 0.29554998670572497}\n",
      "[12] Acetylcholine arg-2 maximized: {'Acetylcholine': 0.27389882223319484, 'Norepinephrine': 0.2154564446819462, 'Dopamine': 0.21980895358192207, 'Serotonin': 0.29083577950293693}\n",
      "[12] Acetylcholine arg-3 maximized: {'Acetylcholine': 0.27789432194281055, 'Norepinephrine': 0.21427085761981085, 'Dopamine': 0.2185994160724132, 'Serotonin': 0.28923540436496536}\n",
      "[12] Acetylcholine arg-4 maximized: {'Acetylcholine': 0.24325232579184894, 'Norepinephrine': 0.22455019823502323, 'Dopamine': 0.22908641314264433, 'Serotonin': 0.3031110628304835}\n",
      "[12] Acetylcholine arg-5 maximized: {'Acetylcholine': 0.25446655324172285, 'Norepinephrine': 0.22122259369424047, 'Dopamine': 0.22569158653105864, 'Serotonin': 0.29861926653297804}\n",
      "[12] Norepinephrine arg-1 maximized: {'Acetylcholine': 0.23531195646836198, 'Norepinephrine': 0.24986283521719746, 'Dopamine': 0.22160845493022394, 'Serotonin': 0.29321675338421654}\n",
      "[12] Norepinephrine arg-2 maximized: {'Acetylcholine': 0.23992092566296, 'Norepinephrine': 0.23517017303336207, 'Dopamine': 0.2259490186540787, 'Serotonin': 0.2989598826495992}\n",
      "[12] Norepinephrine arg-3 maximized: {'Acetylcholine': 0.23531195646836198, 'Norepinephrine': 0.24986283521719752, 'Dopamine': 0.22160845493022394, 'Serotonin': 0.29321675338421654}\n",
      "[12] Norepinephrine arg-4 maximized: {'Acetylcholine': 0.23531195646836198, 'Norepinephrine': 0.24986283521719752, 'Dopamine': 0.22160845493022394, 'Serotonin': 0.29321675338421654}\n",
      "[12] Norepinephrine arg-5 maximized: {'Acetylcholine': 0.23764017954625627, 'Norepinephrine': 0.2424408296172895, 'Dopamine': 0.22380109285125713, 'Serotonin': 0.2961178979851971}\n",
      "[12] Dopamine arg-1 maximized: {'Acetylcholine': 0.23869798363743217, 'Norepinephrine': 0.22034601054524336, 'Dopamine': 0.24352000276859292, 'Serotonin': 0.2974360030487316}\n",
      "[12] Dopamine arg-2 maximized: {'Acetylcholine': 0.23395293455544394, 'Norepinephrine': 0.21596577817325313, 'Dopamine': 0.2585579794691319, 'Serotonin': 0.291523307802171}\n",
      "[12] Dopamine arg-3 maximized: {'Acetylcholine': 0.23752947392742751, 'Norepinephrine': 0.21926734013102656, 'Dopamine': 0.24722323565191653, 'Serotonin': 0.29597995028962937}\n",
      "[12] Dopamine arg-4 maximized: {'Acetylcholine': 0.23752947392742751, 'Norepinephrine': 0.21926734013102656, 'Dopamine': 0.24722323565191653, 'Serotonin': 0.29597995028962937}\n",
      "[12] Dopamine arg-5 maximized: {'Acetylcholine': 0.23634908969703658, 'Norepinephrine': 0.2181777081529357, 'Dopamine': 0.2509641011830408, 'Serotonin': 0.29450910096698696}\n",
      "[12] Serotonin arg-1 maximized: {'Acetylcholine': 0.24177189611452635, 'Norepinephrine': 0.22318358940021082, 'Dopamine': 0.22769219697807633, 'Serotonin': 0.3073523175071865}\n",
      "[12] Serotonin arg-2 maximized: {'Acetylcholine': 0.24177189611452635, 'Norepinephrine': 0.22318358940021082, 'Dopamine': 0.22769219697807633, 'Serotonin': 0.3073523175071865}\n",
      "[12] Serotonin arg-3 maximized: {'Acetylcholine': 0.24028001464183374, 'Norepinephrine': 0.22180640922589692, 'Dopamine': 0.226287195918783, 'Serotonin': 0.3116263802134863}\n",
      "[12] Serotonin arg-4 maximized: {'Acetylcholine': 0.2357373791168696, 'Norepinephrine': 0.21761302811712588, 'Dopamine': 0.22200910289237188, 'Serotonin': 0.32464048987363253}\n",
      "[12] Serotonin arg-5 maximized: {'Acetylcholine': 0.2357373791168696, 'Norepinephrine': 0.21761302811712588, 'Dopamine': 0.22200910289237188, 'Serotonin': 0.3246404898736326}\n"
     ]
    }
   ],
   "source": [
    "for id, patient in patients.items():\n",
    "    print(f'[{id}] Orig probabily: {get_softmax(patient)}')\n",
    "    for molecule in patient['molecules'].keys():\n",
    "        for arg in range(5):\n",
    "            p = deepcopy(patient)\n",
    "            p['molecules'][molecule][arg] = 1\n",
    "            print(f'[{id}] {molecule} arg-{arg + 1} maximized: {get_softmax(p)}')\n"
   ]
  },
  {
   "cell_type": "code",
   "execution_count": null,
   "metadata": {},
   "outputs": [],
   "source": []
  }
 ],
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