Perhaps you've had problems programmatically creating tiles with Tilemill, or are concerned about the future stability of project (or you just like playing with geo software).
brew install mapnik --with-gdal --with-postgresql
sudo pip install -U PIL modestmaps simplejson werkzeug
git clone https://github.com/TileStache/TileStache.git TileStache
cd TileStache