Cython with Numpy. From 2.2s to 0.4s.

cyhash.pyx

# cython: infer_types=True

# Use the C math library to avoid Python overhead.
from libc cimport math
# For boundscheck below.
import cython
# We're lazy so we'll let Numpy handle our array memory management.
import numpy as np
# You would normally also import the Numpy pxd to get faster access to the Numpy
# API, but it requires some fancier compilation options so I'll leave it out for
# this demo.
# cimport numpy as np

import random

# This is a small function that doesn't need to be exposed to Python at all. Use
# `cdef` instead of `def` and inline it.
cdef inline int h3(int a,int b,int c,int d, int m,int x):
    return (a*x**2 + b*x+c) % m

# If we want to live fast and dangerously, we tell cython not to check our array
# indices for IndexErrors. This means we CAN overrun our array and crash the
# program or screw up our stack. Use with caution.
# @cython.boundscheck(False)
# `cpdef` so that calling this function from another Cython (or C) function can
# skip the Python function call overhead, while still allowing us to use it from
# Python.
cpdef floyd(int[:] inputx):
    # Type the variables in the scope of the function.
    cdef int a,b,c,d, value, cyclelimit
    cdef unsigned int dupefound = 0
    cdef unsigned int nohashcalls = 0
    cdef unsigned int loopno, pos, j

    # `m` has type int because inputx is already a Cython memory view and
    # `infer-types` is on.
    m = inputx.shape[0]

    cdef unsigned int loops = int(m*math.log(m))

    # Again using the memory view, but letting Numpy allocate an array of zeros.
    cdef int[:] listofpos = np.zeros(m, dtype=np.int32)

    # Keep this random sampling out of the loop
    cdef int[:, :] randoms = np.random.randint(0, m, (loops, 5)).astype(np.int32)

    for loopno in xrange(loops):
        if (dupefound == 1):
            break

        # From our precomputed array
        a = randoms[loopno, 0]
        b = randoms[loopno, 1]
        c = randoms[loopno, 2]
        d = randoms[loopno, 3]
        pos = randoms[loopno, 4]

        value = inputx[pos]

        # Unforunately, Memory View does not support "vectorized" operations
        # like standard Numpy arrays. Otherwise we'd use listofpos *= 0 here.
        for j in xrange(m):
            listofpos[j] = 0

        listofpos[pos] = 1
        setofvalues = set((value,))
        cyclelimit = int(math.sqrt(m))
        for j in xrange(cyclelimit):
            pos = h3(a, b, c, d, m, inputx[pos])
            nohashcalls += 1
            if (inputx[pos] in setofvalues):
                if (listofpos[pos]==1):
                    dupefound = 0
                else:
                    dupefound = 1
                    print "Duplicate found at position", pos, " and value", inputx[pos]
                break
            listofpos[pos] = 1
            setofvalues.add(inputx[pos])
    return dupefound, nohashcalls

cyhash_orig.pyx

import math, random
cdef int a,b,c,d,m,pos,value, cyclelimit, nohashcalls   
def h3(int a,int b,int c,int d, int m,int x):
    return (a*x**2 + b*x+c) %m    
def floyd(inputx):
    dupefound, nohashcalls = (0,0)
    m = len(inputx)
    loops = int(m*math.log(m))
    for loopno in xrange(loops):
        if (dupefound == 1):
            break
        a = random.randrange(m)
        b = random.randrange(m)
        c = random.randrange(m)
        d = random.randrange(m)
        pos = random.randrange(m)
        value = inputx[pos]
        listofpos = [0] * m
        listofpos[pos] = 1
        setofvalues = set([value])
        cyclelimit = int(math.sqrt(m))
        for j in xrange(cyclelimit):
            pos = h3(a,b, c,d, m, inputx[pos])
            nohashcalls += 1    
            if (inputx[pos] in setofvalues):
                if (listofpos[pos]==1):
                    dupefound = 0
                else:
                    dupefound = 1
                    print "Duplicate found at position", pos, " and value", inputx[pos]
                break
            listofpos[pos] = 1
            setofvalues.add(inputx[pos])
    return dupefound, nohashcalls 

run.py

#/usr/bin/env python

import math, random
import numpy as np

import pyximport; pyximport.install()
import cyhash as cy

m = 5000
inputx = np.array(random.sample(xrange(m**2), m), dtype=np.int32)
(dupefound, nohashcalls) = cy.floyd(inputx)