I tried this with an x86_64 try build running on an M1 machine, and it worked. It was this build (from Aug 26, 2021) and I'll use it as an example.
You need the XUL.dSYM and a local source checkout of the same revision, and then tell lldb about them like this:
% lldb /Volumes/Firefox\ Nightly/Firefox Nightly.app/Contents/MacOS/firefox
(lldb) target modules add "/Volumes/Firefox Nightly/Firefox Nightly.app/Contents/MacOS/XUL" --symfile ~/Downloads/target.crashreporter-symbols-full/XUL/E13E188188F0368CB252DC67549D134B0/XUL.dSYM/Contents/Resources/DWARF/XUL