1. remove bloatware from Dock
2. enable autohide Dock, move it to your preferred position 
3. disable "natural" scroll (System Preferences -> Trackpad -> Scroll & Zoom)
4. if machine w/o touchbar, change F-keys/Fn behavior in Keyboard preferences; for touchbar machines no choice seems good :-/
5. disable everything in Keyboard -> Text tab
6. `defaults write -g CGFontRenderingFontSmoothingDisabled -bool NO` to make fonts on external monitors not look like crap
7. change screenshot location in Screenshot.app (defaults to ~/Desktop/)