My settings for Python dev env for macOS (file: ~/.bash_profile or ~/.zshrc)

.zshrc

#
# My settings for python dev env on MacBook.
# I use HomeBrew to install python and python3
# cat ~/.profile
#

# load all completions
source /usr/local/etc/bash_completion.d/*

# Python VirtualEnv
export WORKON_HOME=~/.virtualenvs
export VIRTUALENVWRAPPER_PYTHON=/usr/local/bin/python3
source /usr/local/bin/virtualenvwrapper.sh

# python: resolve problem with install MySQL-python
export CFLAGS=-Qunused-arguments
export CPPFLAGS=-Qunused-arguments

# MySQL
homebrew=/usr/local/bin:/usr/local/sbin:/usr/local/mysql/bin
export PATH=$homebrew:$PATH

# Django
#source ~/.django_completion
#export LC_CTYPE=ru_RU.UTF-8
#export LANG=ru_RU.UTF-8

# Aliases (shortcuts)
alias rm_pyc="find . -type f -name '*.pyc' -exec rm {} \;"
alias rm_orig="find . -type f -name '*.orig' -exec rm {} \;"
alias find_pyc="find . -type f -name '*.pyc'"
alias celeryd='./manage.py celeryd --loglevel=debug --verbosity=2'
alias celerybeat='./manage.py celerybeat --verbosity=2 --loglevel=DEBUG'
alias mkvirtualenv3='mkvirtualenv --python=$(which python3)'

# Fix broken virtual env after python version upgrade
function fix_virtualenv {
  #
  # Usage: fix_virtualenv project_name
  #
  PROJECT_NAME=$1
  # First of all, delete all broken links
  find ~/.virtualenvs/$PROJECT_NAME/ -type l -delete
  # Then create new links to the current Python version
  virtualenv ~/.virtualenvs/$PROJECT_NAME/
}

You can find other useful information about work with Python on macOS here: https://github.com/1st/python-on-osx