In VSCode, the default key binding for ctrl+, points to the settings menu.
The number of times people access settings windows is far more less than the number of times s-expressions are executed.
I modified calva key bindings to use ctrl+, (ctrl+oem_comma) instead of ctrl+alt+c.
I also remapped the workbench settings keybinding to ctrl+, g so that it is still accessible.
I left the Paredit settings unmodified. However, they are included in the below gist for reference.
All the when clause of "when": "editorTextFocus && editorLangId == 'clojure'" so that their scope is limited to clojure only.
// Place your key bindings in this file to override the defaults
[
{ "key": "ctrl+oem_comma g", "command": "workbench.action.openSettings" , "when": "editorTextFocus && editorLangId == 'clojure'"},
{ "key": "ctrl+oem_comma j", "command": "calva.jackIn" , "when": "editorTextFocus && editorLangId == 'clojure'"},
{ "key": "ctrl+oem_comma c", "command": "calva.connect", "when": "editorTextFocus && editorLangId == 'clojure'" },
{ "key": "ctrl+oem_comma t", "command": "calva.toggleCLJCSession", "when": "editorTextFocus && editorLangId == 'clojure'" },
{ "key": "ctrl+oem_comma r", "command": "calva.recreateCljsRepl", "when": "editorTextFocus && editorLangId == 'clojure'" },
{ "key": "ctrl+oem_comma s", "command": "calva.selectCurrentForm", "when": "editorTextFocus && editorLangId == 'clojure'" },
{ "key": "escape", "command": "calva.clearInlineResults",
"when": "editorTextFocus && !editorHasMultipleSelections && !editorReadOnly && !hasOtherSuggestions && !suggestWidgetVisible && editorLangId == 'clojure'" },
{ "key": "ctrl+oem_comma e", "command": "calva.evaluateSelection" , "when": "editorTextFocus && editorLangId == 'clojure'"},
{ "key": "ctrl+oem_comma space", "command": "calva.evaluateCurrentTopLevelForm" , "when": "editorTextFocus && editorLangId == 'clojure'"},
{ "key": "ctrl+oem_comma p", "command": "calva.evaluateSelectionPrettyPrint" , "when": "editorTextFocus && editorLangId == 'clojure'"},
{ "key": "ctrl+oem_comma ctrl+p", "command": "calva.evaluateCurrentTopLevelFormPrettyPrint" , "when": "editorTextFocus && editorLangId == 'clojure'"},
{ "key": "ctrl+oem_comma r", "command": "calva.evaluateSelectionReplace" , "when": "editorTextFocus && editorLangId == 'clojure'"},
{ "key": "ctrl+oem_comma c", "command": "calva.evaluateSelectionAsComment" , "when": "editorTextFocus && editorLangId == 'clojure'"},
{ "key": "ctrl+oem_comma ctrl+c", "command": "calva.copyLastResults" , "when": "editorTextFocus && editorLangId == 'clojure'"},
{ "key": "ctrl+oem_comma enter", "command": "calva.loadFile" , "when": "editorTextFocus && editorLangId == 'clojure'"},
{ "key": "ctrl+oem_comma ctrl+u", "command": "calva.requireREPLUtilities" , "when": "editorTextFocus && editorLangId == 'clojure'"},
{ "key": "ctrl+oem_comma l", "command": "calva.lintFile" , "when": "editorTextFocus && editorLangId == 'clojure'"},
{ "key": "ctrl+oem_comma t", "command": "calva.runNamespaceTests" , "when": "editorTextFocus && editorLangId == 'clojure'"},
{ "key": "ctrl+oem_comma shift+t", "command": "calva.runAllTests" , "when": "editorTextFocus && editorLangId == 'clojure'"},
{ "key": "ctrl+oem_comma ctrl+t", "command": "calva.rerunTests" , "when": "editorTextFocus && editorLangId == 'clojure'"},
{ "key": "ctrl+oem_comma ctrl+alt+n", "command": "calva.loadNamespace" , "when": "editorTextFocus && editorLangId == 'clojure'"},
{ "key": "ctrl+oem_comma alt+n", "command": "calva.setREPLNamespace" , "when": "editorTextFocus && editorLangId == 'clojure'"},
{ "key": "ctrl+oem_comma ctrl+alt+e", "command": "calva.evalCurrentFormInREPLWindow" , "when": "editorTextFocus && editorLangId == 'clojure'"},
{ "key": "ctrl+oem_comma ctrl+alt+space", "command": "calva.evalCurrentTopLevelFormInREPLWindow" , "when": "editorTextFocus && editorLangId == 'clojure'"},
{ "key": "ctrl+alt+right", "command": "paredit.forwardSexp",
"when": "calva:pareditValid && paredit:keyMap =~ /original|strict/" },
{ "key": "ctrl+alt+left", "command": "paredit.backwardSexp",
"when": "calva:pareditValid && paredit:keyMap =~ /original|strict/" },
{ "key": "ctrl+down", "command": "paredit.forwardDownSexp",
"when": "calva:pareditValid && paredit:keyMap =~ /original|strict/" },
{ "key": "ctrl+up", "command": "paredit.backwardUpSexp",
"when": "calva:pareditValid && paredit:keyMap =~ /original|strict/" },
{ "key": "ctrl+shift+alt+right", "command": "paredit.closeList",
"when": "calva:pareditValid && paredit:keyMap =~ /original|strict/" },
{ "key": "ctrl+alt+w space", "command": "paredit.rangeForDefun",
"when": "calva:pareditValid && paredit:keyMap =~ /original|strict/" },
{ "key": "ctrl+w", "command": "paredit.sexpRangeExpansion",
"when": "calva:pareditValid && paredit:keyMap =~ /original|strict/" },
{ "key": "ctrl+shift+w", "command": "paredit.sexpRangeContraction",
"when": "calva:pareditValid && paredit:keyMap =~ /original|strict/" },
{ "key": "ctrl+shift+c ctrl+right", "command": "paredit.yankForwardSexp",
"when": "calva:pareditValid && paredit:keyMap =~ /original|strict/" },
{ "key": "ctrl+shift+c ctrl+left", "command": "paredit.yankBackwardSexp",
"when": "calva:pareditValid && paredit:keyMap =~ /original|strict/" },
{ "key": "ctrl+shift+c ctrl+down", "command": "paredit.yankForwardDownSexp",
"when": "calva:pareditValid && paredit:keyMap =~ /original|strict/" },
{ "key": "ctrl+shift+c ctrl+up", "command": "paredit.yankBackwardUpSexp",
"when": "calva:pareditValid && paredit:keyMap =~ /original|strict/" },
{ "key": "ctrl+shift+c ctrl+alt+right", "command": "paredit.yankCloseList",
"when": "calva:pareditValid && paredit:keyMap =~ /original|strict/" },
{ "key": "ctrl+shift+c space", "command": "paredit.yankRangeForDefun",
"when": "calva:pareditValid && paredit:keyMap =~ /original|strict/" },
{ "key": "ctrl+shift+x right", "command": "paredit.cutForwardSexp",
"when": "calva:pareditValid && paredit:keyMap =~ /original|strict/" },
{ "key": "ctrl+shift+x left", "command": "paredit.cutBackwardSexp",
"when": "calva:pareditValid && paredit:keyMap =~ /original|strict/" },
{ "key": "ctrl+shift+x down", "command": "paredit.cutForwardDownSexp",
"when": "calva:pareditValid && paredit:keyMap =~ /original|strict/" },
{ "key": "ctrl+shift+x up", "command": "paredit.cutBackwardUpSexp",
"when": "calva:pareditValid && paredit:keyMap =~ /original|strict/" },
{ "key": "ctrl+shift+x ctrl+alt+right", "command": "paredit.cutCloseList",
"when": "calva:pareditValid && paredit:keyMap =~ /original|strict/" },
{ "key": "ctrl+shift+x space", "command": "paredit.cutRangeForDefun",
"when": "calva:pareditValid && paredit:keyMap =~ /original|strict/" },
{ "key": "ctrl+right", "command": "paredit.slurpSexpForward",
"when": "calva:pareditValid && paredit:keyMap =~ /original|strict/" },
{ "key": "ctrl+shift+left", "command": "paredit.slurpSexpBackward",
"when": "calva:pareditValid && paredit:keyMap =~ /original|strict/" },
{ "key": "ctrl+left", "command": "paredit.barfSexpForward",
"when": "calva:pareditValid && paredit:keyMap =~ /original|strict/" },
{ "key": "ctrl+shift+right", "command": "paredit.barfSexpBackward",
"when": "calva:pareditValid && paredit:keyMap =~ /original|strict/" },
{ "key": "ctrl+alt+s", "command": "paredit.spliceSexp",
"when": "calva:pareditValid && paredit:keyMap =~ /original|strict/" },
{ "key": "ctrl+shift+alt+s", "command": "paredit.splitSexp",
"when": "calva:pareditValid && paredit:keyMap =~ /original|strict/" },
{ "key": "ctrl+delete", "command": "paredit.killSexpForward",
"when": "calva:pareditValid && paredit:keyMap =~ /original|strict/" },
{ "key": "ctrl+backspace", "command": "paredit.killSexpBackward",
"when": "calva:pareditValid && paredit:keyMap =~ /original|strict/" },
{ "key": "ctrl+alt+down", "command": "paredit.spliceSexpKillForward",
"when": "calva:pareditValid && paredit:keyMap =~ /original|strict/" },
{ "key": "ctrl+alt+up", "command": "paredit.spliceSexpKillBackward",
"when": "calva:pareditValid && paredit:keyMap =~ /original|strict/" },
{ "key": "ctrl+shift+alt+9", "command": "paredit.wrapAroundParens",
"when": "calva:pareditValid && paredit:keyMap =~ /original|strict/" },
{ "key": "ctrl+alt+oem_4", "command": "paredit.wrapAroundSquare",
"when": "calva:pareditValid && paredit:keyMap =~ /original|strict/" },
{ "key": "ctrl+shift+alt+oem_4", "command": "paredit.wrapAroundCurly",
"when": "calva:pareditValid && paredit:keyMap =~ /original|strict/" },
{ "key": "ctrl+alt+i", "command": "paredit.indentRange",
"when": "calva:pareditValid && paredit:keyMap =~ /original|strict/" },
{ "key": "delete", "command": "paredit.deleteForward",
"when": "editorTextFocus && !editorHasMultipleSelections && !editorReadOnly && paredit:keyMap == 'strict' && editorLangId =~ /clojure|scheme|lisp/" },
{ "key": "backspace", "command": "paredit.deleteBackward",
"when": "editorTextFocus && !editorHasMultipleSelections && !editorReadOnly && paredit:keyMap == 'strict' && editorLangId =~ /clojure|scheme|lisp/" },
{ "key": "ctrl+alt+delete", "command": "deleteRight",
"when": "calva:pareditValid && paredit:keyMap =~ /original|strict/" },
{ "key": "ctrl+alt+backspace", "command": "deleteLeft",
"when": "calva:pareditValid && paredit:keyMap =~ /original|strict/" },
{ "key": "tab", "command": "calva-fmt.formatCurrentForm",
"when": "editorTextFocus && !editorReadOnly && !hasOtherSuggestions && !suggestWidgetVisible && editorLangId == 'clojure'" },
{ "key": "ctrl+alt+l", "command": "calva-fmt.alignCurrentForm",
"when": "editorTextFocus && !editorReadOnly && !hasOtherSuggestions && !suggestWidgetVisible && editorLangId == 'clojure'" },
{ "key": "ctrl+alt+p", "command": "calva-fmt.inferParens",
"when": "editorTextFocus && !editorReadOnly && !hasOtherSuggestions && !suggestWidgetVisible && editorLangId == 'clojure'" },
{ "key": "ctrl+i", "command": "calva-fmt.tabIndent",
"when": "editorTextFocus && !editorReadOnly && !hasOtherSuggestions && !suggestWidgetVisible && editorLangId == 'clojure'" },
{ "key": "ctrl+shift+i", "command": "calva-fmt.tabDedent",
"when": "editorTextFocus && !editorReadOnly && !hasOtherSuggestions && !suggestWidgetVisible && editorLangId == 'clojure'" }
]