Created
January 22, 2025 09:38
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Convert TMM-based normalization factor and library size from edgeR to DESeq2-compatible 1-centered size factors
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| # Say we have a SingleCellExperiment "se" | |
| nf <- se$norm.factors | |
| ls <- se$lib.size | |
| # effective library size | |
| els <- ls * nf | |
| # size factors centered around 1 | |
| geomeans <- exp(mean(log(els))) | |
| sf <- els / geomeans |
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