Startup.cs

using System;
using System.Diagnostics;
using System.Linq;
using Microsoft.Owin;
using Owin;

[assembly: OwinStartup(typeof(WebApplication5.Startup))]

namespace WebApplication5
{
    public class Startup
    {
        public void Configuration(IAppBuilder app)
        {
            app.Use((ctx, next) =>
            {
                // enable cache-control injection if caching strategy has not been setted manually
                if (!ctx.Response.Headers.Keys.Any(x => x.Equals("Cache-Control", StringComparison.InvariantCultureIgnoreCase)))
                {
                    ctx.Response.Headers.Add("Cache-Control", new []{"no-cache, no-store, must-revalidate"});
                    Debug.WriteLine("The Cache-Control was been added.");
                }

                Debug.WriteLine("The Cache-Control header is exists.");

                return next();
            });
        }
    }
}