Created
April 7, 2014 12:29
-
-
Save FedericoV/10019386 to your computer and use it in GitHub Desktop.
String Output:
This file contains hidden or bidirectional Unicode text that may be interpreted or compiled differently than what appears below. To review, open the file in an editor that reveals hidden Unicode characters.
Learn more about bidirectional Unicode characters
| query | |
| http://string-db.org/api/tsv/resolveList | |
| data | |
| output=tsv&identifiers=%250Dhob1%250Dfim1%250Dscd1%250Dpom1%250Drho2%250Drho1%250Dpsd1%250Dalp14%250Dfor3%250Dpck2%250Dpck1%250Dalp6%250Dscd2%250Dskb1%250Dsid2%250Dtea1%250Dmal3%250Dtea4%250Dmkh1%250Dppb1%250Dkin1%250Dmob2%250Dcki2%250Datb2%250Dpal1%250Dmyo1%250Dgef1%250Dsty1%250Drga1%250Dshk1%250Dssp1%250Dpmk1%250Dact1%250Drgf1%250Dsts5%250Dtea2%250Darp3%250Dtea3%250Dtip1%250Defc25%250D&request=resolveList&species=4896 | |
| queryIndex stringId ncbiTaxonId taxonName preferredName annotation | |
| 0 4896.SPBC21D10.12-1 4896 Schizosaccharomyces pombe hob1 Protein hob1; Has a role in DNA damage signaling as a part of stress response processes | |
| 9 4896.SPBC119.08-1 4896 Schizosaccharomyces pombe spm1 Mitogen-activated protein kinase spm1; Regulates cell integrity and functions coordinately with the protein kinase C pathway (pck1 and pck2). Involved the regulation of wall architecture, cell shape, cytokinesis in exponential and stationary phase, and metabolism of ions | |
| 9 4896.SPAC16.01-1 4896 Schizosaccharomyces pombe rho2 GTP-binding protein rho2; Involved in cell morphogenesis, the maintenance of growth direction, control of polarity and of cell wall integrity. Regulates the synthesis of alpha-D-glucan through activation of pck2 | |
| 9 4896.SPCC736.15-1 4896 Schizosaccharomyces pombe SPCC736.15 Probable sphingolipid long chain base-responsive protein C736.15; Negative regulator of cell wall integrity (CWI) in unstressed cells, probably by inhibiting protein kinase ksg1/ppk21 activity and regulating their downstream CWI pathways pck2-MAP kinase pathway and protein kinase gad8 pathway. Activity may be regulated by the transient increase of sphingolipid long chain bases (LCBs) during heat stress (By similarity) | |
| 9 4896.SPAC3C7.02c-1 4896 Schizosaccharomyces pombe SPAC3C7.02c-1 Probable sphingolipid long chain base-responsive protein C3C7.02c; Negative regulator of cell wall integrity (CWI) in unstressed cells, probably by inhibiting protein kinase ksg1/ppk21 activity and regulating their downstream CWI pathways pck2-MAP kinase pathway and protein kinase gad8 pathway. Activity may be regulated by the transient increase of sphingolipid long chain bases (LCBs) during heat stress (By similarity) | |
| 9 4896.SPBC12D12.04c-1 4896 Schizosaccharomyces pombe pck2 Protein kinase C-like 2; Involved in the control of the cell shape. Target of the inhibitor staurosporine | |
| 10 4896.SPBC119.08-1 4896 Schizosaccharomyces pombe spm1 Mitogen-activated protein kinase spm1; Regulates cell integrity and functions coordinately with the protein kinase C pathway (pck1 and pck2). Involved the regulation of wall architecture, cell shape, cytokinesis in exponential and stationary phase, and metabolism of ions | |
| 10 4896.SPAC17G8.14c-1 4896 Schizosaccharomyces pombe pck1 Protein kinase C-like 1; Involved in the control of the cell shape. Target of the inhibitor staurosporine | |
| 11 4896.SPBC428.20c-1 4896 Schizosaccharomyces pombe alp6 Spindle pole body component alp6; Component of the gamma tubule complex that is required for the regulation of both interphase microtubules and mitotic bipolar spindles | |
| 12 4896.SPAC22H10.07-1 4896 Schizosaccharomyces pombe scd2 Protein scd2/ral3; Required for mating and morphogenesis. Interacts directly with scd1 and with cdc42. May bridge and facilitate scd1 and cdc42 interactions | |
| 12 4896.SPAC16E8.09-1 4896 Schizosaccharomyces pombe scd1 Rho guanine nucleotide exchange factor scd1; Required for mating and morphogenesis. May contain a cryptic binding site for cdc42 that is enhanced by binding Ras. Interacts directly with scd2. Promotes the exchange of cdc42-bound GDP by GTP. Involved in septation and stimulates the elongation of conjugation tubes | |
| 13 4896.SPBC16H5.11c-1 4896 Schizosaccharomyces pombe skb1 Protein arginine N-methyltransferase skb1; Positively modulates the shk1 kinase function. May be a mediator of hyperosmotic stress response | |
| 13 4896.SPBC1604.14c-1 4896 Schizosaccharomyces pombe shk1 Serine/threonine-protein kinase shk1/pak1; MAP4K component of the MAPK pathway required for the mating pheromone response. Phosphorylates histone H2B to form H2BS10ph (By similarity). Phosphorylates tea1. Required for skb1- dependent mitotic inhibitory function. Regulates microtubule dynamics and cell polarity | |
| 14 4896.SPAC24B11.11c-1 4896 Schizosaccharomyces pombe sid2 Serine/threonine-protein kinase sid2; Part of a signaling pathway. Required for initiation of medial ring constriction and septation | |
| 15 4896.SPAC2F7.03c-1 4896 Schizosaccharomyces pombe pom1 Dual specificity protein kinase pom1; Involved in localization of polarized growth and cytokinesis. May interact with both the actin and microtubule cytoskeleton. Requires tea1 for localization to the cell ends but not to the cell center | |
| 15 4896.SPBC1706.01-1 4896 Schizosaccharomyces pombe tea4 Tip elongation aberrant protein Tea4; Cell polarity factor essential for the bipolar localization and function of structures containing the cell-end marker tea1 during the normal cell cycle. Regulates cell polarity in complex with tea1 and together with the stress signaling MAPK cascade, contributes to cell polarity maintenance under stress conditions. Required for the localization of for3 at the cell tip specifically during initiation of bipolar growth. During the new end take off (NETO), formation of a protein complex that includes tea1, tea4 and for3 is necessary and sufficient for [...] | |
| 15 4896.SPCC1223.06-1 4896 Schizosaccharomyces pombe tea1 Tip elongation aberrant protein 1; Cell polarity protein. Acts as an end marker, directing the growth machinery to the cell poles. Involved in the regulation of microtubular organization, affecting the maintenance of a single central axis. Prevents the curling of microtubule tips around the cell ends and is required for the retention of polarity factors such as pom1, tip1 and tea2 at the cell ends, necessary for the cell to grow in a straight line. Links tip1 and tea4 in a common complex | |
| 15 4896.SPBC1604.14c-1 4896 Schizosaccharomyces pombe shk1 Serine/threonine-protein kinase shk1/pak1; MAP4K component of the MAPK pathway required for the mating pheromone response. Phosphorylates histone H2B to form H2BS10ph (By similarity). Phosphorylates tea1. Required for skb1- dependent mitotic inhibitory function. Regulates microtubule dynamics and cell polarity | |
| 15 4896.SPBC1604.20c-1 4896 Schizosaccharomyces pombe tea2 Kinesin-like protein tea2; Promotes microtubule growth, possibly through interactions with the microtubule end, and is important for establishing and maintaining polarized growth along the long axis of the cell. Acts as a kinesin motor protein that moves along microtubules and is required for proper localization of tea1 and tip1 to the cell tips and microtubules, respectively. ATPase activity stimulated via interaction with mal3 | |
| 15 4896.SPBC530.04-1 4896 Schizosaccharomyces pombe mod5 Cell polarity protein mod5; With tea1, acts in a positive-feedback loop in the microtubule-mediated regulation of cell polarity. Involved in the anchoring of tea1 at the cortex as well as the correct localization of tea3 | |
| 16 4896.SPAC18G6.15-1 4896 Schizosaccharomyces pombe mal3 Microtubule integrity protein mal3; May play a role in regulating the integrity of microtubules possibly by influencing their stability. Involved in an anchoring mechanism to maintain tea2 and tip1 at growing microtubule ends. Strongly stimulates the ATPase activity of tea2 | |
| 16 4896.SPBC1604.20c-1 4896 Schizosaccharomyces pombe tea2 Kinesin-like protein tea2; Promotes microtubule growth, possibly through interactions with the microtubule end, and is important for establishing and maintaining polarized growth along the long axis of the cell. Acts as a kinesin motor protein that moves along microtubules and is required for proper localization of tea1 and tip1 to the cell tips and microtubules, respectively. ATPase activity stimulated via interaction with mal3 | |
| 17 4896.SPCC1223.06-1 4896 Schizosaccharomyces pombe tea1 Tip elongation aberrant protein 1; Cell polarity protein. Acts as an end marker, directing the growth machinery to the cell poles. Involved in the regulation of microtubular organization, affecting the maintenance of a single central axis. Prevents the curling of microtubule tips around the cell ends and is required for the retention of polarity factors such as pom1, tip1 and tea2 at the cell ends, necessary for the cell to grow in a straight line. Links tip1 and tea4 in a common complex | |
| 17 4896.SPBC1706.01-1 4896 Schizosaccharomyces pombe tea4 Tip elongation aberrant protein Tea4; Cell polarity factor essential for the bipolar localization and function of structures containing the cell-end marker tea1 during the normal cell cycle. Regulates cell polarity in complex with tea1 and together with the stress signaling MAPK cascade, contributes to cell polarity maintenance under stress conditions. Required for the localization of for3 at the cell tip specifically during initiation of bipolar growth. During the new end take off (NETO), formation of a protein complex that includes tea1, tea4 and for3 is necessary and sufficient for [...] | |
| 18 4896.SPBC543.07-1 4896 Schizosaccharomyces pombe skh1 MAP kinase kinase skh1/pek1; Involved in the mkh1 signal transduction pathway that plays a role in cell wall integrity. Activates spm1/pmk1 via phosphorylation | |
| 18 4896.SPAC1F3.02c-1 4896 Schizosaccharomyces pombe mkh1 MAP kinase kinase kinase mkh1; May regulate cell morphology, cell wall integrity, salt resistance, cell cycle reentry from stationary-phase arrest, and filamentous growth in response to stress. Activates the MAP kinase kinase skh1/pek1 by phosphorylation | |
| 1 4896.SPBC1778.06c-1 4896 Schizosaccharomyces pombe fim1 Fimbrin; Binds to actin, and functionally associates with actin structures involved in the development and maintenance of cell polarity. Plays a role in cytokinesis. Plays important roles in mating and in spore formation | |
| 19 4896.SPAC19G12.14-1 4896 Schizosaccharomyces pombe its3 Phosphatidylinositol-4-phosphate 5-kinase its3; Involved, together with the calcineurin ppb1, in cytokinesis | |
| 19 4896.SPBP4H10.04-1 4896 Schizosaccharomyces pombe ppb1 Serine/threonine-protein phosphatase 2B catalytic subunit; Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin. Appears to be involved in cytokinesis, mating, transport, nuclear and spindle pole body positioning, and cell shape | |
| 20 4896.SPBC4F6.06-1 4896 Schizosaccharomyces pombe kin1 Protein kinase kin1; Has a role in establishing the characteristic rod cell shape. Important for cell polarity and is involved in directing growth to the cell ends | |
| 21 4896.SPCC970.04c-1 4896 Schizosaccharomyces pombe mob2 Maintenance of ploidy protein mob2; Required for coordinating polarized cell growth during interphase with the onset of mitosis | |
| 22 4896.SPBP35G2.05c-1 4896 Schizosaccharomyces pombe cki2 Casein kinase I homolog 2; Casein kinases are operationally defined by their preferential utilization of acidic proteins such as caseins as substrates. May contribute to the regulation of morphology | |
| 23 4896.SPBC800.05c-1 4896 Schizosaccharomyces pombe tub1 Tubulin alpha-2 chain; Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha-chain | |
| 24 4896.SPCP1E11.04c-1 4896 Schizosaccharomyces pombe pal1 Protein pal1; Involved in cellular morphogenesis and cell wall integrity. Important for the maintenance of a cylindrical cell shape | |
| 25 4896.SPBC13E7.09-1 4896 Schizosaccharomyces pombe vrp1 Verprolin; Involved in cytoskeletal organization and cellular growth. May exert its effects on the cytoskeleton directly, or indirectly via proline-binding proteins such as profilin or proteins possessing SH3 domains. Plays a role in actin patch assembly by enhancing the ability of myo1 to stimulate actin polymerization by the Arp2/3 complex | |
| 25 4896.SPBC146.13c-1 4896 Schizosaccharomyces pombe myo1 Myosin-1; Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex. Contributes to proper septation by transporting vesicles containing septal material to the division site and is involved in the formation of sterol-rich membrane domains at the cell division site. Required also for mating | |
| 26 4896.SPAC24H6.09-1 4896 Schizosaccharomyces pombe gef1 Rho guanine nucleotide exchange factor gef1; Has a role in the control of cell polarity and cytokinesis. Involved in bipolar growth, via modulation of cdc42- shk1-orb6 signaling, and septum formation. Stimulates guanine nucleotide exchange of cdc42 | |
| 27 4896.SPAC24B11.06c-1 4896 Schizosaccharomyces pombe sty1 Mitogen-activated protein kinase sty1; Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes. Involved in osmoregulation and stress response pathways leading to an efficient start of sexual differentiation. Supports translation initiation and facilitates adaptation to environmental stress in part through reducing eIF2-alpha phosphorylation. Links the cell- cycle G2/M control with changes in the extracellular environment that [...] | |
| 27 4896.SPCC1322.08-1 4896 Schizosaccharomyces pombe srk1 Serine/threonine-protein kinase srk1; Has a role in the regulation of meiosis via the sty1 stress-activated MAPK pthway. Inhibits nitrogen-limitation induced arrest at G1 | |
| 27 4896.SPBC887.10-1 4896 Schizosaccharomyces pombe mcs4 Response regulator mcs4; Response regulator that coordinately controls the stress activated wak1-wis1-sty1 MAP kinase pathway and fission yeast cell cycle | |
| 27 4896.SPBC409.07c-1 4896 Schizosaccharomyces pombe wis1 Protein kinase wis1; Dosage-dependent regulator of mitosis with serine/ threonine protein kinase activity. May play a role in the integration of nutritional sensing with the control over entry into mitosis. It may interact with cdc25, wee1 and win1. May activate sty1 | |
| 27 4896.SPCC74.06-1 4896 Schizosaccharomyces pombe mak3 Peroxide stress-activated histidine kinase mak3; Involved in the control of the SAPK-dependent transcriptional response to peroxide stress. Regulates sty1 activity | |
| 27 4896.SPCC576.03c-1 4896 Schizosaccharomyces pombe tpx1 Peroxiredoxin tpx1; Physiologically important antioxidant which constitutes an enzymatic defense against sulfur-containing radicals. Can provide protection against a thiol-containing oxidation system but not against an oxidation system without thiol. Required for the peroxide-induced activation of pap1 via its oxidation and for the nuclear accumulation of pap1. Required also for activation of sty1. Reduced by srx1 and this regulation acts as a molecular switch controlling the transcriptional response to hydrogen peroxide | |
| 27 4896.SPAC27E2.09-1 4896 Schizosaccharomyces pombe mak2 Peroxide stress-activated histidine kinase mak2; Involved in the control of the SAPK-dependent transcriptional response to peroxide stress. Regulates sty1 activity | |
| 27 4896.SPAPYUG7.02c-1 4896 Schizosaccharomyces pombe sin1 Stress-activated map kinase-interacting protein 1; Interacts with the sty1 MAP kinase and has a role in the timing of the initiation of mitosis | |
| 28 4896.SPBC3F6.05-1 4896 Schizosaccharomyces pombe rga1 Rho-type GTPase-activating protein 1; GTPase-activating protein for Rho1. Involved in the F- actin patch localization, cell morphogenesis, regulation of septation, and cell wall synthesis | |
| 2 4896.SPAC22H10.07-1 4896 Schizosaccharomyces pombe scd2 Protein scd2/ral3; Required for mating and morphogenesis. Interacts directly with scd1 and with cdc42. May bridge and facilitate scd1 and cdc42 interactions | |
| 2 4896.SPAC16E8.09-1 4896 Schizosaccharomyces pombe scd1 Rho guanine nucleotide exchange factor scd1; Required for mating and morphogenesis. May contain a cryptic binding site for cdc42 that is enhanced by binding Ras. Interacts directly with scd2. Promotes the exchange of cdc42-bound GDP by GTP. Involved in septation and stimulates the elongation of conjugation tubes | |
| 2 4896.SPBC336.03-1 4896 Schizosaccharomyces pombe efc25 Ras guanine nucleotide exchange factor efc25; Has a role in chromosome segregation and cell morphology upstream of the ras1-scd1 pathway. Promotes the exchange of ras1- bound GDP by GTP leading to its activation | |
| 29 4896.SPCC16C4.08c-1 4896 Schizosaccharomyces pombe skb15 Shk1 kinase-binding protein 15; Negatively regulates pak1/shk1 kinase activity leading to proper execution of cytoskeletal remodeling and cytokinetic functions | |
| 29 4896.SPBC16H5.11c-1 4896 Schizosaccharomyces pombe skb1 Protein arginine N-methyltransferase skb1; Positively modulates the shk1 kinase function. May be a mediator of hyperosmotic stress response | |
| 29 4896.SPCC24B10.13-1 4896 Schizosaccharomyces pombe skb5 Shk1 kinase-binding protein 5; Stimulates catalytic function of the p21-activated kinase homolog shk1 | |
| 29 4896.SPBC1604.14c-1 4896 Schizosaccharomyces pombe shk1 Serine/threonine-protein kinase shk1/pak1; MAP4K component of the MAPK pathway required for the mating pheromone response. Phosphorylates histone H2B to form H2BS10ph (By similarity). Phosphorylates tea1. Required for skb1- dependent mitotic inhibitory function. Regulates microtubule dynamics and cell polarity | |
| 29 4896.SPAC24H6.09-1 4896 Schizosaccharomyces pombe gef1 Rho guanine nucleotide exchange factor gef1; Has a role in the control of cell polarity and cytokinesis. Involved in bipolar growth, via modulation of cdc42- shk1-orb6 signaling, and septum formation. Stimulates guanine nucleotide exchange of cdc42 | |
| 30 4896.SPAC664.11-1 4896 Schizosaccharomyces pombe ssc1 Heat shock 70 kDa protein, mitochondrial | |
| 30 4896.SPAC110.04c-1 4896 Schizosaccharomyces pombe pss1 Heat shock protein homolog pss1; Required for normal growth at various temperatures | |
| 30 4896.SPCC297.03-1 4896 Schizosaccharomyces pombe ssp1+ Serine/threonine-protein kinase ssp1; Involved in actin localization and thus in polarized cell growth | |
| 31 4896.SPCC757.09c-1 4896 Schizosaccharomyces pombe rnc1 RNA-binding protein rnc1; Binds and stabilizes pmp1 mRNA and hence acts as a negative regulator of pmk1 signaling. Overexpression suppresses the Cl(-) sensitivity of calcineurin deletion | |
| 31 4896.SPBC1685.01-1 4896 Schizosaccharomyces pombe pmp1 Tyrosine-protein phosphatase pmp1; Dual specificity phosphatase that dephosphorylates MAP kinase pmk1 on a Tyr. Has a role in chloride ion homeostasis by inactivating this pmk1 MAP kinase pathway | |
| 31 4896.SPBC119.08-1 4896 Schizosaccharomyces pombe spm1 Mitogen-activated protein kinase spm1; Regulates cell integrity and functions coordinately with the protein kinase C pathway (pck1 and pck2). Involved the regulation of wall architecture, cell shape, cytokinesis in exponential and stationary phase, and metabolism of ions | |
| 32 4896.SPBC32H8.12c-1 4896 Schizosaccharomyces pombe act1 Actin; Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells | |
| 33 4896.SPCC645.07-1 4896 Schizosaccharomyces pombe rgf1 Rho1 guanine nucleotide exchange factor 1; Stimulates the exchange of Rho1 and Rho5 GDP-bound form into GTP-bound form. Controls septum formation, cell wall synthesis and localization of F-actin patches. Coordinates actin deposition with cell wall biosynthesis during bipolar growth | |
| 34 4896.SPCC16C4.09-1 4896 Schizosaccharomyces pombe sts5 Protein sts5; Required for the maintenance of cell shape during interphase. Required for localization of cortical actin to the growing tips before mitosis | |
| 35 4896.SPAC18G6.15-1 4896 Schizosaccharomyces pombe mal3 Microtubule integrity protein mal3; May play a role in regulating the integrity of microtubules possibly by influencing their stability. Involved in an anchoring mechanism to maintain tea2 and tip1 at growing microtubule ends. Strongly stimulates the ATPase activity of tea2 | |
| 35 4896.SPCC1223.06-1 4896 Schizosaccharomyces pombe tea1 Tip elongation aberrant protein 1; Cell polarity protein. Acts as an end marker, directing the growth machinery to the cell poles. Involved in the regulation of microtubular organization, affecting the maintenance of a single central axis. Prevents the curling of microtubule tips around the cell ends and is required for the retention of polarity factors such as pom1, tip1 and tea2 at the cell ends, necessary for the cell to grow in a straight line. Links tip1 and tea4 in a common complex | |
| 35 4896.SPAC3C7.12-1 4896 Schizosaccharomyces pombe tip1 Tip elongation protein 1; Has a role in stabilizing and targeting the growing tips of the microtubules along the long axis of the cell, directing them to the ends of the cell. Acts as a cargo for tea2 | |
| 35 4896.SPBC1604.20c-1 4896 Schizosaccharomyces pombe tea2 Kinesin-like protein tea2; Promotes microtubule growth, possibly through interactions with the microtubule end, and is important for establishing and maintaining polarized growth along the long axis of the cell. Acts as a kinesin motor protein that moves along microtubules and is required for proper localization of tea1 and tip1 to the cell tips and microtubules, respectively. ATPase activity stimulated via interaction with mal3 | |
| 36 4896.SPAC630.03-1 4896 Schizosaccharomyces pombe act2 Actin-related protein 3; Functions as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the pointed end of the daughter actin filament (By similarity). May be involved in cytokinesis | |
| 37 4896.SPAC6G10.02c-1 4896 Schizosaccharomyces pombe tea3 Tip elongation aberrant protein 3; Acts as a cell end marker required for efficient new end take-off (NETO), whereby growth is activated at the cell end to generate bipolarity in extending cells. Also required for proper placement of the septum | |
| 37 4896.SPBC530.04-1 4896 Schizosaccharomyces pombe mod5 Cell polarity protein mod5; With tea1, acts in a positive-feedback loop in the microtubule-mediated regulation of cell polarity. Involved in the anchoring of tea1 at the cortex as well as the correct localization of tea3 | |
| 38 4896.SPAC18G6.15-1 4896 Schizosaccharomyces pombe mal3 Microtubule integrity protein mal3; May play a role in regulating the integrity of microtubules possibly by influencing their stability. Involved in an anchoring mechanism to maintain tea2 and tip1 at growing microtubule ends. Strongly stimulates the ATPase activity of tea2 | |
| 38 4896.SPCC1223.06-1 4896 Schizosaccharomyces pombe tea1 Tip elongation aberrant protein 1; Cell polarity protein. Acts as an end marker, directing the growth machinery to the cell poles. Involved in the regulation of microtubular organization, affecting the maintenance of a single central axis. Prevents the curling of microtubule tips around the cell ends and is required for the retention of polarity factors such as pom1, tip1 and tea2 at the cell ends, necessary for the cell to grow in a straight line. Links tip1 and tea4 in a common complex | |
| 38 4896.SPAC3C7.12-1 4896 Schizosaccharomyces pombe tip1 Tip elongation protein 1; Has a role in stabilizing and targeting the growing tips of the microtubules along the long axis of the cell, directing them to the ends of the cell. Acts as a cargo for tea2 | |
| 38 4896.SPBC1604.20c-1 4896 Schizosaccharomyces pombe tea2 Kinesin-like protein tea2; Promotes microtubule growth, possibly through interactions with the microtubule end, and is important for establishing and maintaining polarized growth along the long axis of the cell. Acts as a kinesin motor protein that moves along microtubules and is required for proper localization of tea1 and tip1 to the cell tips and microtubules, respectively. ATPase activity stimulated via interaction with mal3 | |
| 3 4896.SPAC2F7.03c-1 4896 Schizosaccharomyces pombe pom1 Dual specificity protein kinase pom1; Involved in localization of polarized growth and cytokinesis. May interact with both the actin and microtubule cytoskeleton. Requires tea1 for localization to the cell ends but not to the cell center | |
| 3 4896.SPCC1223.06-1 4896 Schizosaccharomyces pombe tea1 Tip elongation aberrant protein 1; Cell polarity protein. Acts as an end marker, directing the growth machinery to the cell poles. Involved in the regulation of microtubular organization, affecting the maintenance of a single central axis. Prevents the curling of microtubule tips around the cell ends and is required for the retention of polarity factors such as pom1, tip1 and tea2 at the cell ends, necessary for the cell to grow in a straight line. Links tip1 and tea4 in a common complex | |
| 39 4896.SPBC336.03-1 4896 Schizosaccharomyces pombe efc25 Ras guanine nucleotide exchange factor efc25; Has a role in chromosome segregation and cell morphology upstream of the ras1-scd1 pathway. Promotes the exchange of ras1- bound GDP by GTP leading to its activation | |
| 4 4896.SPAC16.01-1 4896 Schizosaccharomyces pombe rho2 GTP-binding protein rho2; Involved in cell morphogenesis, the maintenance of growth direction, control of polarity and of cell wall integrity. Regulates the synthesis of alpha-D-glucan through activation of pck2 | |
| 5 4896.SPBC3F6.05-1 4896 Schizosaccharomyces pombe rga1 Rho-type GTPase-activating protein 1; GTPase-activating protein for Rho1. Involved in the F- actin patch localization, cell morphogenesis, regulation of septation, and cell wall synthesis | |
| 5 4896.SPCC645.07-1 4896 Schizosaccharomyces pombe rgf1 Rho1 guanine nucleotide exchange factor 1; Stimulates the exchange of Rho1 and Rho5 GDP-bound form into GTP-bound form. Controls septum formation, cell wall synthesis and localization of F-actin patches. Coordinates actin deposition with cell wall biosynthesis during bipolar growth | |
| 5 4896.SPAC1006.06-1 4896 Schizosaccharomyces pombe rgf2 Rho1 guanine nucleotide exchange factor 2; Stimulates the exchange of Rho1 and Rho5 GDP-bound form into GTP-bound form. Controls septum formation, cell wall synthesis and localization of F-actin patches | |
| 5 4896.SPAC1F7.03-1 4896 Schizosaccharomyces pombe pkd2 TRP-like ion channel pkd2; Acts as a key signaling component in the regulation of cell shape and cell wall synthesis through interaction with GTPase Rho1 | |
| 5 4896.SPBC17F3.01c-1 4896 Schizosaccharomyces pombe rga5 Rho-GTPase-activating protein 5; GTPase-activating protein for Rho1. Has a role in the negative regulation of (1-3)beta-D-glucan synthase activity and cell integrity | |
| 5 4896.SPCC645.06c-1 4896 Schizosaccharomyces pombe rgf3 Rho1 guanine nucleotide exchange factor 3; Stimulates the exchange of Rho1 GDP-bound form into GTP- bound form. Regulates, via interaction and activation of Rho1, beta-1,3-glucan biosynthesis and cell wall integrity during septation. Involved in the regulation of contractile ring assembly | |
| 5 4896.SPAC1F7.04-1 4896 Schizosaccharomyces pombe rho1 GTP-binding protein rho1; Involved in the regulation of cell wall growth and actin cytoskeleton organization. Activates (1,3)-beta-D-glucan synthase | |
| 6 4896.SPAC25B8.03-1 4896 Schizosaccharomyces pombe psd1 Phosphatidylserine decarboxylase proenzyme 1, mitochondrial; May be involved in the regulation of phospholipid biosynthesis and interorganelle trafficking of phosphatidylserine (By similarity) | |
| 6 4896.SPBC16E9.18-1 4896 Schizosaccharomyces pombe SPBC1E8.01 Phosphatidylserine decarboxylase proenzyme 2, mitochondrial; May be involved in the regulation of phospholipid biosynthesis and interorganelle trafficking of phosphatidylserine (By similarity) | |
| 7 4896.SPAC890.02c-1 4896 Schizosaccharomyces pombe alp7 Microtubule protein alp7; Required for bipolar spindle formation and proper chromosome segregation. Has an indirect role in connecting the kinetochores and the plus end of pole to chromosome microtubules by targeting alp14 to the spindle pole body. Involved in the emergence of large microtubule-organizing centers (MTOC) in interphase cells. Attaches to the minus ends of microtubules and associates with the sites of microtubule attachment on the nuclear envelope. This leads to the stabilzation of the microtubule bundles | |
| 7 4896.SPCC895.07-1 4896 Schizosaccharomyces pombe alp14 Spindle pole body component alp14; Required for bipolar spindle formation and proper chromosome segregation. Has a role in connecting the kinetochores and the plus end of pole to chromosome microtubules. Also required for the activation of the spindle checkpoint pathway | |
| 8 4896.SPAC6F6.06c-1 4896 Schizosaccharomyces pombe rax2 Polarized growth protein rax2; Controls cell polarity, through the G1 phase of mitosis, via regulation of for3 localization. Required for actin cable formation where it directs the spatial distribution of the actin cables | |
| 8 4896.SPBC1706.01-1 4896 Schizosaccharomyces pombe tea4 Tip elongation aberrant protein Tea4; Cell polarity factor essential for the bipolar localization and function of structures containing the cell-end marker tea1 during the normal cell cycle. Regulates cell polarity in complex with tea1 and together with the stress signaling MAPK cascade, contributes to cell polarity maintenance under stress conditions. Required for the localization of for3 at the cell tip specifically during initiation of bipolar growth. During the new end take off (NETO), formation of a protein complex that includes tea1, tea4 and for3 is necessary and sufficient for [...] | |
| 8 4896.SPCC895.05-1 4896 Schizosaccharomyces pombe for3 Formin-3; Involved in controlling polarized cell growth. Required for interphase actin cable formation and microtubule organization |
Sign up for free
to join this conversation on GitHub.
Already have an account?
Sign in to comment