Style the Genesis comment count number

functions.php

<?php

// Don't include above <?php

add_filter( 'genesis_post_comments_shortcode', 'prefix_post_comments_shortcode' );
/**
 * Amend the post comments shortcode to add extra markup for styling.
 *
 * @author Gary Jones
 * @link   http://gamajo.com/style-comment-number/
 *
 * @param string $output HTML markup.
 *
 * @return string HTML markup.
 */
function prefix_post_comments_shortcode( $output ) {
    return preg_replace( '/#comments"\>(\d+) Comment/', '#comments"><span class="entry-comments-number">$1</span> Comment', $output );
}

functions_.php

<?php

// Don't include above <?php

add_filter( 'genesis_post_info', 'prefix_post_info' );
/**
 * Filter the post info line.
 * 
 * Copies the default output and changes it to include a `zero` attribute for the post_comments shortcode.
 * 
 * @author Gary Jones
 * @link   http://gamajo.com/style-comment-number/
 *
 * @param string $output HTML markup, likely with shortcodes.
 *
 * @return string HTML markup.
 */
function prefix_post_info( $post_info ) {
	return '[post_date] ' . __( 'by', 'textdomain' ) . ' [post_author_posts_link] [post_comments zero="0 Comments"] [post_edit]';
}

output.html

<span class="entry-comments"><!-- class will be post-comments for XHTML child themes -->
  <a href="http://example.com/post-name/#comments"><span class="entry-comments-number">1</span> Comment</a>
</span>

style.css

.entry-comments-number {
	font-size: 16px;
}