Mark topics on twitter "not interested" with some JS.

twitter_mark_topics_not_interested.js

/*
* Mark all the topics visual on a Twitter page as "not interested".
* Someday maybe I'll reach the end.
*
* Currently I run from the console, will eventually write an extension.
*/

// From your feed
document
  .querySelectorAll('[aria-label="Set as not interested"]')
  .forEach((element) => element.click());

// From the Topics page
// Accessible at https://twitter.com/{USERNAME}/topics
document
  .querySelectorAll('[aria-label="Dismiss"]')
  .forEach((element) => element.click());