Created
August 1, 2014 19:34
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To get the Beta values for the 65 SNP probes
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# object must be an RGChannelSet object from the minfi package | |
getSnpBeta <- function(object){ | |
require(minfi) | |
minfi:::.isRG(object) | |
manifest <- getManifest(object) | |
snpProbesII <- getProbeInfo(manifest, type = "SnpII")$Name | |
M.II <- getGreen(object)[getProbeInfo(object, type = "SnpII")$AddressA,] | |
U.II <- getRed(object)[getProbeInfo(object, type = "SnpII")$AddressA,] | |
snpProbesI.Green <- getProbeInfo(manifest, type = "SnpI")[getProbeInfo(manifest, type = "SnpI")$Color=="Grn",] | |
snpProbesI.Red <- getProbeInfo(manifest, type = "SnpI")[getProbeInfo(manifest, type = "SnpI")$Color=="Red",] | |
M.I.Red <- getRed(object)[snpProbesI.Red $AddressB,] | |
U.I.Red <- getRed(object)[snpProbesI.Red $AddressA,] | |
M.I.Green <- getGreen(object)[snpProbesI.Green$AddressB,] | |
U.I.Green <- getGreen(object)[snpProbesI.Green$AddressA,] | |
M <- rbind(M.II, M.I.Red, M.I.Green) | |
U <- rbind(U.II, U.I.Red, U.I.Green) | |
rownames(M) <- rownames(U) <- c(snpProbesII, snpProbesI.Red$Name, snpProbesI.Green$Name) | |
beta <- M/(U+M+100) | |
return(beta) | |
} |
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