wsgi.py

from flask import make_response, Flask
import pdfkit
import os

path_wkhtmltopdf = r'C:\Program Files\wkhtmltopdf\bin\wkhtmltopdf.exe'
config = pdfkit.configuration(wkhtmltopdf=path_wkhtmltopdf)
pdfoptions = {
    "print-media-type": None,
    "page-size": "A4",
    "dpi": "300",
    "margin-top": "0",
    "margin-bottom": "0",
    "margin-left": "0",
    "margin-right": "0",
    "zoom": "1.25"
}

validRoutes = [ 'sitehtml' ]
app = Flask(__name__)

@app.route("/<string:nroute>")
def html_to_pdf(nroute):
    if nroute in validRoutes :
        if nroute == 'sitehtml' :
            pdfkit.from_file('C:\Apache24\htdocs\SitoHtmlToPdf\HTMLIntermedio.html','C:\Apache24\htdocs\SitoHtmlToPdf\HTMLIntermedio.pdf', configuration=config, options=pdfoptions)
            if os.path.exists('C:\Apache24\htdocs\SitoHtmlToPdf\HTMLIntermedio.pdf'):
                with open('C:\Apache24\htdocs\SitoHtmlToPdf\HTMLIntermedio.pdf', 'rb', buffering=0) as static_file:
                    r = make_response(static_file.read())
                    r.mimetype = 'application/pdf'
        return r

@app.route("/")
def nothinguseful():
    r = make_response( {"message":"INVALID_ROUTE"} )
    r.mimetype = 'application/json'
    return r
if __name__ == "__main__":
     app.run()