Nice Drupal gist found on http://www.systemseed.com/blog/drupal-nginx-fastcgi-setup-and-configuration

Drupal Nginx config

server {
    listen   80;
    server_name  mydomain.com;
    rewrite ^/(.*) http://mydomain.com permanent;
}
  
server {
    listen 80;
    server_name www.mydomain.com;
  
    access_log /path/to/mydomain.com/log/access.log;
    error_log /path/to/mydomain.com/log/error.log;
  
    root /path/to/drupal/root/;
    index index.php;
  
    if (!-e $request_filename) {
        rewrite ^/(.*)$ /index.php?q=$1 last;
    }
  
    error_page 404 index.php;
  
    # hide protected files
    location ~* .(engine|inc|info|install|module|profile|po|sh|.*sql|theme|tpl(.php)?|xtmpl)$|^(code-style.pl|Entries.*|Repository|Root|Tag|Template)$ {
      deny all;
    }
  
    # hide backup_migrate files
    location ~* ^/files/backup_migrate {
      deny all;
    }
  
    # serve static files directly
    location ~* ^.+.(jpg|jpeg|gif|css|png|js|ico)$ {
        access_log        off;
        expires           30d;
    }  
  
    location ~ .php$ {
        fastcgi_pass 127.0.0.1:9000;
        fastcgi_index index.php;
        fastcgi_param  SCRIPT_FILENAME   $document_root$fastcgi_script_name;
        fastcgi_param  QUERY_STRING     $query_string;
        fastcgi_param  REQUEST_METHOD   $request_method;
        fastcgi_param  CONTENT_TYPE     $content_type;
        fastcgi_param  CONTENT_LENGTH   $content_length;
    }
}