Duplication of GUI presented on Reddit, just to see what it would be like to write.

Commodore64.py

import PySimpleGUI as sg
import subprocess

def slider(key, initial_value):
    return [sg.Slider((1, 200), resolution=0, default_value=initial_value, orientation='h', size=(10,15),key=key)]

layout = [  [sg.Text('Pitch')], slider('pitch', 64),
            [sg.Text('Speed')], slider('speed',72),
            [sg.Text('Mouth')], slider('mouth',128),
            [sg.Text('Throat')],slider('throat',128),
            [sg.CBox('Phoenetic', key='CBP')], [sg.CBox('Save', key='CBS')],[sg.CBox('Output', key='CBO')],
            [sg.Input('Commodore64', key='SaveName', size=(16,1))],
            [sg.Button('Play')]]

window = sg.Window('Commodore 64').Layout(layout)

while True:
    event, v = window.Read()
    if event is None:
        break
    if event == 'Play':
        command = f"sam.exe -pitch {int(v['pitch'])} -speed {int(v['speed'])} -mouth {int(v['mouth'])} -throat {int(v['throat'])} {v['SaveName']}"
        if v['CBP']:
            command += f" -phoenetic {1*v['CBP']}"
        if v['CBS']:
            command += f" -wav {v['SaveName']}_p{int(v['pitch'])}m{int(v['mouth'])}s{int(v['speed'])}t{int(v['throat'])}.wav"
        if v['CBO']:
            subprocess.call(command)
        print(command)

You can execute this code online by going here:
https://repl.it/@PySimpleGUI/PySimpleGUI-Commodore64-Example

If the output checkbox were checked, this subprocess call would be made (what was printed when program executed):
sam.exe -pitch 64 -speed 72 -mouth 128 -throat 128 -phoenetic 1 -wav Commodore64_p64m128s72t128.wav

This code duplicates the code located in this Reddit post
https://www.reddit.com/r/Python/comments/b7qsf5/made_a_gui_for_a_c64_speech_synthesizer_and_a/

    from tkinter import *
    import subprocess
    
    def createcommand():
    	output = "sam.exe"
    	output += ' ' 
    	output += "-pitch " + str(pitch.get())
    	output += ' ' 
    	output += "-speed " + str(speed.get())
    	output += ' '
    	output += "-mouth " + str(mouth.get())
    	output += ' '
    	output += "-throat " + str(throat.get())
    	output += ' '
    	if(phonetic.get()):
    		output += "-phonetic"
    		output += ' '
    	output += textbox.get()
    	output += ' '
    	return output
    	
    def play():
    	command = createcommand()
    	if(save.get()):
    		subprocess.call(command + "-wav " + textbox.get() + "_p" + str(pitch.get()) + 'm' + str(mouth.get()) + 's' + str(speed.get()) + 't' + str(throat.get()) + ".wav")
    		print(command + "-wav " + textbox.get() + "_p" + str(pitch.get()) + 'm' + str(mouth.get()) + 's' + str(speed.get()) + 't' + str(throat.get()) + ".wav")
    	else:
    		print (command)
    	if(output.get()):
    		subprocess.call(command)
    
    master = Tk()
    
    pitch = Scale(master, from_=1, to=200, orient=HORIZONTAL, label = "pitch")
    pitch.set(64)
    pitch.pack()
    
    speed = Scale(master, from_=1, to=200, orient=HORIZONTAL, label = "speed")
    speed.set(72)
    speed.pack()
    
    mouth = Scale(master, from_=1, to=200, orient=HORIZONTAL, label = "mouth")
    mouth.set(128)
    mouth.pack()
    
    throat = Scale(master, from_=1, to=200, orient=HORIZONTAL, label = "throat")
    throat.set(128)
    throat.pack()
    
    phonetic = IntVar()
    checkBoxPhonetic = Checkbutton(variable=phonetic, onvalue=1, offvalue=0, text="Phonetic")
    checkBoxPhonetic.pack()
    
    save = IntVar()
    checkBoxSave = Checkbutton(variable=save, onvalue=1, offvalue=0, text="Save")
    checkBoxSave.pack()
    
    output = IntVar()
    outputBoxOutput = Checkbutton(variable=output, onvalue=1, offvalue=0, text="Output")
    outputBoxOutput.pack()
    outputBoxOutput.select()
    
    textbox = Entry(master)
    textbox.pack()
    textbox.delete(0, END)
    textbox.insert(0, "Commodore 64")
    
    Button(master, text='Play', command=play).pack()
    
    mainloop()