Mysql My.cnf Optimization - Best Performance For 1000 + Sites Web Server

my.cnf

# Optimized MySQL configuration for cPanel servers by Kani Baspinar - Updated June 2016
#
# The settings provided below are a starting point for a 24GB RAM server with 8 CPU cores.
# If you have less or more resources available you MUST adjust accordingly to save CPU, RAM and disk I/O usage.
# To fine tune these settings for your system, use MySQL DB diagnostics tools like:
# Test your configuration ; https://launchpad.net/mysql-tuning-primer
# or
# http://blog.mysqltuner.com/download/
# Note that if there is NO comment beside a setting, then you don't need to adjust it.
#
[client]
#password	= your_password
port		= 3306
socket		= /var/lib/mysql/mysql.sock

# Here follows entries for some specific programs

# The MariaDB server
[mysqld]
port		= 3306
socket		= /var/lib/mysql/mysql.sock
skip-external-locking
key_buffer_size = 256M
max_allowed_packet=268435456
table_open_cache = 256
sort_buffer_size = 1M
read_buffer_size = 1M
read_rnd_buffer_size = 4M
myisam_sort_buffer_size = 64M
thread_cache_size = 8
query_cache_size= 16M
# Try number of CPU's x 2 for thread_concurrency
thread_concurrency = 16

# Point the following paths to different dedicated disks
#tmpdir		= /tmp/

# Don't listen on a TCP/IP port at all. This can be a security enhancement,
# if all processes that need to connect to mysqld run on the same host.
# All interaction with mysqld must be made via Unix sockets or named pipes.
# Note that using this option without enabling named pipes on Windows
# (via the "enable-named-pipe" option) will render mysqld useless!
# 
#skip-networking

# Replication Master Server (default)
# binary logging is required for replication
log-bin=mysql-bin

# binary logging format - mixed recommended
binlog_format=mixed

# required unique id between 1 and 2^32 - 1
# defaults to 1 if master-host is not set
# but will not function as a master if omitted
server-id	= 1

# Replication Slave (comment out master section to use this)
#
# To configure this host as a replication slave, you can choose between
# two methods :
#

# 2) Set the variables below. However, in case you choose this method, then
#    start replication for the first time (even unsuccessfully, for example
#    if you mistyped the password in master-password and the slave fails to
#    connect), the slave will create a master.info file, and any later
#    change in this file to the variables' values below will be ignored and
#    overridden by the content of the master.info file, unless you shutdown
#    the slave server, delete master.info and restart the slaver server.
#    For that reason, you may want to leave the lines below untouched
#    (commented) and instead use CHANGE MASTER TO (see above)
#
# required unique id between 2 and 2^32 - 1
# (and different from the master)
# defaults to 2 if master-host is set
# but will not function as a slave if omitted
#server-id       = 2
#
# The replication master for this slave - required
#master-host     =   <hostname>
#
# The username the slave will use for authentication when connecting
# to the master - required
#master-user     =   <username>
#
# The password the slave will authenticate with when connecting to
# the master - required
#master-password =   <password>
#
# The port the master is listening on.
# optional - defaults to 3306
#master-port     =  <port>
#
# binary logging - not required for slaves, but recommended
#log-bin=mysql-bin
# ============================================================ #
# =============== Custom server tweaks [start] =============== #
# ============================================================ #

default_storage_engine = InnoDB
innodb_buffer_pool_size = 2G # Use up to 70-80% of RAM & optionally check if /proc/sys/vm/swappiness is set to 0. Use Tuning Primer or MySQL Tuner to adjust accordingly.
innodb_file_per_table = 1
innodb_flush_log_at_trx_commit = 0
innodb_flush_method = O_DIRECT
innodb_log_buffer_size = 8M
innodb_log_file_size = 128M # Delete the ib_logfile0 & ib_logfile1 files in /var/lib/mysql whenever you change this, even the first time you set it up, as the default value is 8M. Don't go above 256M.

open_files_limit=10000
[mysqldump]
quick
max_allowed_packet = 16M

[mysql]
no-auto-rehash
# Remove the next comment character if you are not familiar with SQL
#safe-updates

[myisamchk]
key_buffer_size = 128M
sort_buffer_size = 128M
read_buffer = 2M
write_buffer = 2M

[mysqlhotcopy]
interactive-timeout