When something like Topaz Video Enhance AI outputs image sequences, keep watch the output folder and auto encode into pieces and delete images so besides some extra storage ios you will not be limited by its output formats(which is just kinda crap).

TVEtifencdaemon.py

import os,sys
import pathlib
import subprocess
import time
rootd=pathlib.Path(__file__).parent.absolute()
os.chdir(rootd)
while True:
    time.sleep(5)
    files=list(rootd.glob('*.tif'))
    filesb=[os.path.basename(str(n))[:-4] for n in files]
    if len(filesb)>=120:
        files=files[:120]
        filesb=filesb[:120]
        di=len(filesb[0])
        si=filesb[0]
        while si[0]=='0' and len(si)!=1:
            si=si[1:]
        si=int(si)
        ei=si+120-1
        ffc=f'ffmpeg -hide_banner -r 30000/1001 -start_number {si} -i "%0{di}d.tif" -frames 120 -vf zscale=m=709:c=0:d=error_diffusion:f=spline36:r=tv,format=yuv420p10le -crf 12 -c:v libx264 -x264opts colormatrix=bt709 "{si}-{ei}".hevc -y'
        e=subprocess.run(ffc,shell=True)
        if e.returncode!=0:
            e=subprocess.run(ffc,shell=True)
        for x in files:
            os.remove(str(x))