First Create Noise Profile This is done using ffmpeg: ffmpeg -i source.mp3 -vn -ss 00:00:18 -t 00:00:20 noisesample.wav Create Noise Profile for Sox sox noisesample.wav -n noiseprof noise_profile_file Reduce noise on source file sox source.mp3 output.mp3 noisered noise_profile_file 0.31