- crystal-gsl - GNU Scientific Library bindings
- crystalla - library for Numerical Methods. It binds to LAPACK and is unashamedly inspired by Numpy
- linalg - Linear algebra library inspired by MATLAB and SciPy.linalg
- linprog - Wrapper for Coin-OR SYMPHONY library - LP and MILP solver
- crystaledge - A pure Vector Math library
- nlopt - Wrapper for NLopt - nonlinear optimization library
- stats - Expressive implementation of statistical distributions and usual math functions
- stats - Common statistics library
- mpi.cr - Message Passing Interface bindings
- crOpenCL - OpenCL bindings
- quartz - A DEVS-based Modeling & Simulation Environment
- netcdfcr - Bindings to libnetcdf v4
- crystalg - A Generic Algorithm Library
- crystal-fann - FANN (Fast Artifical Neural Network) binding
- crystal-learn - Sklearn-like machine-learning library
- grey_matter - A basic artificial neural network library
- machine - Simple machine learning algorithm
- tensorflow.cr - Bindings for TensorFlow
- ai4cr - Artificial Intelligence for Crystal
- cadmium - Natural Language Processing (NLP) library for Crystal
- biocrystal - Porting the bioruby project to Crystal
- BioSeq - Bioinformatics Library for Crystal
- graphviz.cr - Generate graphviz dot file
- nuplot - Running Gnuplot with Crystal
- prngs - Some PRNGs implementation
- crystal-random