Toggle Debug and Verbose preference in PowerShell with shortcut keys. Add the script to your Microsoft.PowerShell_profile.ps1

Toggle-Preference.ps1

Set-PSReadlineKeyHandler -Chord "Ctrl+1" -BriefDescription 'Toggle $DebugPreference' -Description 'Toggle $DebugPreference between Continue and SilentlyContiinue' -ScriptBlock {
    if($DebugPreference -eq 'Continue')
    {
        Write-Debug "Setting DebugPreference=SilentlyContinue"
        Set-Variable -Name DebugPreference -Value "SilentlyContinue" -Scope Global -Force
        return
    }
    if($DebugPreference -eq 'SilentlyContinue')
    {
        Set-Variable -Name DebugPreference -Value "Continue" -Scope Global -Force
        Write-Debug "Setting DebugPreference=$DebugPreference"
        return
    }
}

Set-PSReadlineKeyHandler -Chord "Ctrl+2" -BriefDescription 'Toggle $VerbosePreference' -Description 'Toggle $VerbosePreference between Continue and SilentlyContiinue' -ScriptBlock {
    if($VerbosePreference -eq 'Continue')
    {
        Write-Verbose "Setting VerbosePreference=SilentlyContinue"
        Set-Variable -Name VerbosePreference -Value "SilentlyContinue" -Scope Global -Force
        return
    }
    if($VerbosePreference -eq 'SilentlyContinue')
    {
        Set-Variable -Name VerbosePreference -Value "Continue" -Scope Global -Force
        Write-Verbose "Setting VerbosePreference=$VerbosePreference"
        return
    }
}

Set-PSReadlineKeyHandler -Chord "Ctrl+3" -BriefDescription 'Toggle $InformationPreference' -Description 'Toggle $InformationPreference between Continue and SilentlyContiinue' -ScriptBlock {
    if($InformationPreference -eq 'Continue')
    {
        Write-Information "Setting InformationPreference=SilentlyContinue"
        Set-Variable -Name InformationPreference -Value "SilentlyContinue" -Scope Global -Force
        return
    }
    if($InformationPreference -eq 'SilentlyContinue')
    {
        Set-Variable -Name InformationPreference -Value "Continue" -Scope Global -Force
        Write-Information "Setting InformationPreference=$InformationPreference"
        return
    }
}

Get-PSReadlineKeyHandler |Where-Object -Property Function -Like "Toggle*" |ForEach-Object {
    "$($_.Key): $($_.Description)"
}

Add the script to your Microsoft.PowerShell_profile.ps1.
This is doesn't work with PowerShell ISE.