Schedule a file for deletion on reboot. Lets you delete locked files and stuff in System32.

nukefile.cs

using System;

namespace NukeFile
{
    class Program
    {
        ///
        /// Consts defined in WINBASE.H
        ///
        [Flags]
        internal enum MoveFileFlags
        {
            MOVEFILE_REPLACE_EXISTING = 1,
            MOVEFILE_COPY_ALLOWED = 2,
            MOVEFILE_DELAY_UNTIL_REBOOT = 4, //This value can be used only if the process is in the context of a user who belongs to the administrators group or the LocalSystem account
            MOVEFILE_WRITE_THROUGH = 8
        }


        /// <summary>
        /// Marks the file for deletion during next system reboot
        /// </summary>
        /// <param name="lpExistingFileName">The current name of the file or directory on the local computer.</param>
        /// <param name="lpNewFileName">The new name of the file or directory on the local computer.</param>
        /// <param name="dwFlags">MoveFileFlags</param>
        /// <returns>bool</returns>
        /// <remarks>http://msdn.microsoft.com/en-us/library/aa365240(VS.85).aspx</remarks>
        [System.Runtime.InteropServices.DllImportAttribute("kernel32.dll", EntryPoint = "MoveFileEx")]
        internal static extern bool MoveFileEx(string lpExistingFileName, string lpNewFileName,
        MoveFileFlags dwFlags);
        static void Main(string[] args)
        {
            if (MoveFileEx(args[0], null, MoveFileFlags.MOVEFILE_DELAY_UNTIL_REBOOT))
                Console.WriteLine("SUCCESS! Scheduled for deletion.");
            else
                Console.WriteLine("FAILED! Error: {0}", System.Runtime.InteropServices.Marshal.GetLastWin32Error());
        }
    }
}