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Alzheimer's Disease Ontology
Raw
ado.clj
(ns net.wikipunk.rdf.ado
"Alzheimer's Disease Ontology is a knowledge-based ontology that encompasses varieties of concepts related to Alzheimer'S Disease, foundamentally structured by upper level Basic Formal Ontology(BFO). This Ontology is enriched by the interrelational entities that demonstrate the nextwork of the understanding on Alzheimer's disease and can be readily applied for text mining."
{:dcat/downloadURL "http://purl.obolibrary.org/obo/ado.owl",
:dcterms/creator ["Astghik Sargsyan"
"Vanessa Lage-Rupprecht"
"Alpha Tom Kodamullil"
"Philipp Wegner"
"Bide Zhang"
"Stephan Gebel"],
:dcterms/description
"Alzheimer's Disease Ontology is a knowledge-based ontology that encompasses varieties of concepts related to Alzheimer'S Disease, foundamentally structured by upper level Basic Formal Ontology(BFO). This Ontology is enriched by the interrelational entities that demonstrate the nextwork of the understanding on Alzheimer's disease and can be readily applied for text mining.",
:dcterms/license "https://creativecommons.org/licenses/by/4.0/",
:dcterms/title "Alzheimer's Disease Ontology (ADO)",
:owl/versionIRI
"http://purl.obolibrary.org/obo/ado/releases/2022-06-11/ado.owl",
:owl/versionInfo "2.0.0",
:rdf/ns-prefix-map
{"Property" "https://www.wikidata.org/wiki/Property:",
"ado" "http://purl.obolibrary.org/obo/ado.owl#",
"cellline" "http://www.ebi.ac.uk/cellline/",
"chebi" "http://purl.obolibrary.org/obo/chebi/",
"dcterms" "http://purl.org/dc/terms/",
"efo" "http://www.ebi.ac.uk/efo/",
"foaf" "http://xmlns.com/foaf/0.1/",
"metadata" "http://data.bioontology.org/metadata/",
"mondo" "http://purl.obolibrary.org/obo/mondo#",
"ncbitaxon" "http://purl.obolibrary.org/obo/ncbitaxon#",
"obo" "http://purl.obolibrary.org/obo/",
"oboInOwl" "http://www.geneontology.org/formats/oboInOwl#",
"owl" "http://www.w3.org/2002/07/owl#",
"owlready_ontology"
"http://www.lesfleursdunormal.fr/static/_downloads/owlready_ontology.owl#",
"protege" "http://protege.stanford.edu/plugins/owl/protege#",
"rdf" "http://www.w3.org/1999/02/22-rdf-syntax-ns#",
"rdfs" "http://www.w3.org/2000/01/rdf-schema#",
"schema" "https://schema.org/",
"skos" "http://www.w3.org/2004/02/skos/core#",
"wiki" "https://www.wikidata.org/wiki/",
"xsd" "http://www.w3.org/2001/XMLSchema#"},
:rdf/type :owl/Ontology,
:rdfa/prefix "ado",
:rdfa/uri "http://purl.obolibrary.org/obo/ado.owl#"})
(def ADO_0000001
"cognitive symptom"
{:db/ident :obo/ADO_0000001,
:obo/IAO_0000115
"Cognitive symptoms involve problems with concentration and memory and can be just as disabling as the other types of symptoms. The onset of cognitive symptoms is usually realised in the same way as negative symptoms in that they only begin to be noticeable after the dominance of psychotic episodes or positive symptoms have either been controlled with medication or diminished with age.",
:obo/ado#CommentOnDefinition "Modified Defintion",
:rdf/type :owl/Class,
:rdfs/label "cognitive symptom",
:rdfs/seeAlso
"https://livingwithschizophreniauk.org/cognitive-symptoms-schizophrenia/",
:rdfs/subClassOf :obo/SYMP_0000480})
(def ADO_0000002
"isTreatmentFor"
{:db/ident :obo/ADO_0000002,
:obo/IAO_0000115
"The subject describes a clinically approved drug or therapy for a condition (object).",
:rdf/type :owl/ObjectProperty,
:rdfs/label {:rdf/language "de",
:rdf/value "isTreatmentFor"}})
(def ADO_0000003
"isSignAndSymptomFor"
{:db/ident :obo/ADO_0000003,
:obo/IAO_0000115
"The subject describes as sign/symptom or multiple signs/symptoms for the object.",
:rdf/type :owl/ObjectProperty,
:rdfs/label {:rdf/language "de",
:rdf/value "isSignAndSymptomFor"}})
(def ADO_0000004
"isRiskFactorFor"
{:db/ident :obo/ADO_0000004,
:obo/IAO_0000115
"The subject possesses characteristics leading to an increased risk in developing a certain phenotype or condition (object). The example of risk factors could be age, family history, consumption of certain products, being exposed to chemicals or radiations, having certain underlying conditions or being infected by an microorganism",
:rdf/type :owl/ObjectProperty,
:rdfs/label {:rdf/language "de",
:rdf/value "isRiskFactorFor"}})
(def ADO_0000005
"isModelFor"
{:db/ident :obo/ADO_0000005,
:obo/IAO_0000115
"The subject serves as an in vivo model for the study of a certain phenotype (object) during pre-clinical phase.",
:rdf/type :owl/ObjectProperty,
:rdfs/label {:rdf/language "de",
:rdf/value "isModelFor"}})
(def ADO_0000006
"isDiagnosisFor"
{:db/ident :obo/ADO_0000006,
:obo/IAO_0000115
"The subject is a technique carried out in a clinical assessment for evaluation of a condition (object).",
:rdf/type :owl/ObjectProperty,
:rdfs/label {:rdf/language "de",
:rdf/value "isDiagnosisFor"}})
(def ADO_0000007
"isClinicalMarkerFor"
{:db/ident :obo/ADO_0000007,
:obo/IAO_0000115
"An subject that is a symptom, a sign, an underlying disease, a molecular abnormality, or a clinical result/outcome characterised as the key marker for the diagnosis/onset/classification of a certain condition (object).",
:rdf/type :owl/ObjectProperty,
:rdfs/label {:rdf/language "de",
:rdf/value "isClinicalMarkerFor"}})
(def ADO_0000008
"isCellularProcessFor"
{:db/ident :obo/ADO_0000008,
:obo/IAO_0000115
"The subject describes any process that is carried out at the cellular level, but not necessarily restricted to a single cell for the object.",
:rdf/type :owl/ObjectProperty,
:rdfs/label {:rdf/language "de",
:rdf/value "isCellularProcessFor"}})
(def ADO_0000009
"isAnatomicalEntityFor"
{:db/ident :obo/ADO_0000009,
:obo/IAO_0000115
"A relation describing an anatomical feature of the referenced object with a material entity.",
:rdf/type :owl/ObjectProperty,
:rdfs/label {:rdf/language "de",
:rdf/value "isAnatomicalEntityFor"},
:rdfs/subPropertyOf :owl/topObjectProperty})
(def ADO_0000010
"TM_BIN_VariantisGeneticRiskFactorFor"
{:db/ident :obo/ADO_0000010,
:owl/equivalentClass {:owl/onProperty :obo/ADO_0000013,
:owl/someValuesFrom :obo/DOID_10652,
:rdf/type :owl/Restriction},
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "TM_BIN_VariantisGeneticRiskFactorFor"}})
(def ADO_0000011
"TM_BIN_isSignAndSymptomFor"
{:db/ident :obo/ADO_0000011,
:owl/equivalentClass {:owl/onProperty :obo/ADO_0000003,
:owl/someValuesFrom :obo/DOID_10652,
:rdf/type :owl/Restriction},
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "TM_BIN_isSignAndSymptomFor"}})
(def ADO_0000012
"TM_BIN_isTreatmentFor"
{:db/ident :obo/ADO_0000012,
:owl/equivalentClass {:owl/onProperty :obo/ADO_0000002,
:owl/someValuesFrom :obo/DOID_10652,
:rdf/type :owl/Restriction},
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "TM_BIN_isTreatmentFor"}})
(def ADO_0000013
"VariantisGeneticRiskFactorFor"
{:db/ident :obo/ADO_0000013,
:obo/IAO_0000115
"The subject gene has variation that can lead to an increased disease risk, but does not directly cause a disease.",
:rdf/type :owl/ObjectProperty,
:rdfs/label {:rdf/language "de",
:rdf/value "VariantisGeneticRiskFactorFor"}})
(def ADO_0000024
"early sign"
{:db/ident :obo/ADO_0000024,
:obo/IAO_0000115
"A sign that arises in the early/preclinical stage of a disease",
:oboInOwl/hasSynonym ["early hint" "early clue"],
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "early sign"},
:rdfs/subClassOf :obo/OGMS_0000024})
(def ADO_0000025
"Early-stage Alzheimer's Disease (mild)"
{:db/ident :obo/ADO_0000025,
:obo/IAO_0000115
"A disease stage at which a person may function independently. He or she may still drive, work and be a part of social activities. Despite this, the person may feel as if he or she is having memory lapses, such as forgetting familiar words or the location of everyday objects.",
:obo/hasDbXref "https://www.alz.org/alzheimers-dementia/stages",
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "Early-stage Alzheimer's Disease (mild)"},
:rdfs/subClassOf :obo/OBI_0000278})
(def ADO_0000032
"Middle-stage Alzheimer's Disease (moderate)"
{:db/ident :obo/ADO_0000032,
:obo/IAO_0000115
"A disease in the middle stage where the dementia symptoms are more pronounced. The person may confuse words, get frustrated or angry, and act in unexpected ways, such as refusing to bathe. Damage to nerve cells in the brain can also make it difficult for the person to express thoughts and perform routine tasks without assistance.",
:obo/hasDbXref "https://www.alz.org/alzheimers-dementia/stages",
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "Middle-stage Alzheimer's Disease (moderate)"},
:rdfs/subClassOf :obo/OBI_0000278})
(def ADO_0000041
"Personality and behavioral changes"
{:db/ident :obo/ADO_0000041,
:obo/hasDbXref
["https://www.nia.nih.gov/health/managing-personality-and-behavior-changes-alzheimers#:~:text=Common%20Changes%20in%20Personality%20and%20Behavior&text=Getting%20upset%2C%20worried%2C%20and%20angry,things%20that%20aren't%20there"
"A behavioral symptom of Alzheimer's disease that encompasses getting upset, worried, and angry more easily. Acting depressed or not interested in things or hiding things or believing that other people are hiding things. It also causes to imagining things that aren't there etc."],
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "Personality and behavioral changes"},
:rdfs/subClassOf [{:owl/onProperty :obo/ADO_0000003,
:owl/someValuesFrom :obo/ADO_0000050,
:rdf/type :owl/Restriction}
:obo/ADO_0000001]})
(def ADO_0000042
"Late-stage Alzheimer's Disease(severe)"
{:db/ident :obo/ADO_0000042,
:obo/IAO_0000115
"A disease at late stage where dementia symptoms are severe. Individuals lose the ability to respond to their environment, to carry on a conversation and, eventually, to control movement. They may still say words or phrases, but communicating pain becomes difficult. As memory and cognitive skills continue to worsen, significant personality changes may take place and individuals need extensive care.",
:obo/hasDbXref "https://www.alz.org/alzheimers-dementia/stages",
:oboInOwl/hasSynonym "Dementia-stage Alzheimer's Disease",
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "Late-stage Alzheimer's Disease(severe)"},
:rdfs/subClassOf :obo/OBI_0000278})
(def ADO_0000048
"preclinical stage of Alzheimer's disease"
{:db/ident :obo/ADO_0000048,
:obo/IAO_0000115
"A disease stage of Alzheimer's disease that begins long before any symptoms become apparent. The symptoms go unnoticed by the patients and people around them and this stage can last for years, possibly even decades.",
:obo/hasDbXref "https://pubmed.ncbi.nlm.nih.gov/21514248/",
:oboInOwl/hasExactSynonym "preclinical Alzheimer",
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "preclinical stage of Alzheimer's disease"},
:rdfs/subClassOf :obo/DOID_10652})
(def ADO_0000049
"mild cognitive impairment due to Alzheimer's disease"
{:db/ident :obo/ADO_0000049,
:obo/IAO_0000115
"A stage of Alzheimer's disease where symptoms appear such as concern regarding a change in cognition (raised either by the patient himself/herself or by an informant who knows the patient well), impairment in one or more cognitive domains, preservation of independence in functional abilities and other non-demented symptoms.",
:obo/hasDbXref "https://pubmed.ncbi.nlm.nih.gov/21514249/",
:oboInOwl/hasSynonym "predementia phase of Alzheimer's disease",
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value
"mild cognitive impairment due to Alzheimer's disease"},
:rdfs/subClassOf :obo/DOID_10652})
(def ADO_0000050
"dementia due to Alzheimer's disease"
{:db/ident :obo/ADO_0000050,
:obo/IAO_0000115
"A disease of which the patient at this stage suffer from memory loss, impaired ability to think, or making decisions that interferes with doing everyday activities.",
:obo/hasDbXref "https://pubmed.ncbi.nlm.nih.gov/27307128/",
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "dementia due to Alzheimer's disease"},
:rdfs/subClassOf :obo/DOID_10652})
(def ADO_0000051
"concern regarding a change in cognition"
{:db/ident :obo/ADO_0000051,
:obo/IAO_0000115
"An emotion milder than worry raised by either the patient, or the informant who knows the patient well, or from a skilled clinician observing, about cognitive changes in the patient.",
:obo/OGG_0000000030 true,
:obo/ado#CommentOnDefinition "Modified definition",
:obo/hasDbXref "https://pubmed.ncbi.nlm.nih.gov/21514249/",
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "concern regarding a change in cognition"},
:rdfs/subClassOf [{:owl/onProperty :obo/ADO_0000003,
:owl/someValuesFrom :obo/ADO_0000049,
:rdf/type :owl/Restriction}
:obo/NBO_0000003]})
(def ADO_0000052
"preservation of independence in functional abilities"
{:db/ident :obo/ADO_0000052,
:obo/IAO_0000115
"A symptom that entails mild problems performing complex functional tasks which they used to perform previously, such as paying bills, preparing a meal, or shopping. The person requires more time, is less efficient, and makes more errors at performing such activities than in the past. Nevertheless, the person generally maintains their independence of function in daily life.",
:obo/OGG_0000000030 true,
:obo/hasDbXref "https://pubmed.ncbi.nlm.nih.gov/21514249/",
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value
"preservation of independence in functional abilities"},
:rdfs/subClassOf [{:owl/onProperty :obo/ADO_0000003,
:owl/someValuesFrom :obo/ADO_0000049,
:rdf/type :owl/Restriction}
:obo/SYMP_0019182]})
(def ADO_0000053
"episodic memory impairment"
{:db/ident :obo/ADO_0000053,
:obo/IAO_0000115
"A mental impairment in the ability to learn and retain new information, or recall information about a specific event that has occurred at a specific time and place.",
:obo/IAO_0000118 "memory impairment",
:obo/OGG_0000000030 true,
:obo/ado#CommentOnDefinition "Modified definition",
:obo/hasDbXref "https://pubmed.ncbi.nlm.nih.gov/21514249/",
:oboInOwl/hasExactSynonym "impairment in episodic memory",
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "episodic memory impairment"},
:rdfs/subClassOf [{:owl/onProperty :obo/ADO_0000003,
:owl/someValuesFrom :obo/ADO_0000049,
:rdf/type :owl/Restriction}
:obo/ADO_0000001]})
(def ADO_0000054
"Free and Cued Selective Reminding Test"
{:db/ident :obo/ADO_0000054,
:obo/IAO_0000115
"A memory test that controls attention and acquisition, by providing category cues in the learning process.",
:obo/OGG_0000000030 true,
:obo/hasDbXref "https://pubmed.ncbi.nlm.nih.gov/25062746/",
:oboInOwl/hasExactSynonym "FCSRT Test",
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "Free and Cued Selective Reminding Test"},
:rdfs/subClassOf [{:owl/onProperty :obo/ADO_0000006,
:owl/someValuesFrom :obo/DOID_10652,
:rdf/type :owl/Restriction}
:obo/NCIT_C20993]})
(def ADO_0000055
"Boston Naming Test"
{:db/ident :obo/ADO_0000055,
:obo/IAO_0000115
"A measure of confrontation naming that takes into account the finding that patients with dysnomia often have greater difficulties with the naming of low frequency objects and consists of 60 black and white line drawings of objects",
:obo/hasDbXref
"https://link.springer.com/referenceworkentry/10.1007/978-0-387-79948-3_869#:~:text=The%20Boston%20Naming%20Test%20(BNT,naming%20of%20low%20frequency%20objects.",
:oboInOwl/hasExactSynonym "BNT Test",
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "Boston Naming Test"},
:rdfs/subClassOf [{:owl/onProperty :obo/ADO_0000006,
:owl/someValuesFrom :obo/DOID_10652,
:rdf/type :owl/Restriction}
:obo/NCIT_C20993]})
(def ADO_0000056
"category and letter verbal fluency test"
{:db/ident :obo/ADO_0000056,
:obo/IAO_0000115
"A short screening test that evaluates language skills and it consists of Semantic verbal Fluency Tests (SFT) and Categorical verbal Fluency Tests (CFT).",
:obo/hasDbXref
"https://www.frontiersin.org/articles/10.3389/fpsyg.2019.02797/full",
:oboInOwl/hasSynonym "verbal fluency test",
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "category and letter verbal fluency test"},
:rdfs/subClassOf [{:owl/onProperty :obo/ADO_0000006,
:owl/someValuesFrom :obo/DOID_10652,
:rdf/type :owl/Restriction}
:obo/NCIT_C20993]})
(def ADO_0000057
"informal cognitive testing"
{:db/ident :obo/ADO_0000057,
:obo/IAO_0000115
"A testing tool that uses a variety of simple and informal techniques, performed by clinicians. For example, the clinician can ask a patient to learn a street address and to recall it after a delay interval of a few minutes.",
:obo/OGG_0000000030 true,
:obo/hasDbXref "https://pubmed.ncbi.nlm.nih.gov/21514249/",
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "informal cognitive testing"},
:rdfs/subClassOf [{:owl/onProperty :obo/ADO_0000006,
:owl/someValuesFrom :obo/DOID_10652,
:rdf/type :owl/Restriction}
:obo/NCIT_C20993]})
(def ADO_0000058
"longitudinal cognitive evaluation"
{:db/ident :obo/ADO_0000058,
:obo/IAO_0000115
"A clinical tool that measures and evaluates cognition of the patient with certain time intervals while maintaining the consistency in parameters employed in testing.",
:obo/hasDbXref
"https://www.sciencedirect.com/science/article/pii/S2352872918300824",
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "longitudinal cognitive evaluation"},
:rdfs/subClassOf [{:owl/onProperty :obo/ADO_0000006,
:owl/someValuesFrom :obo/DOID_10652,
:rdf/type :owl/Restriction}
:obo/NCIT_C15273]})
(def ADO_0000059
"probable Alzheimer dementia"
{:db/ident :obo/ADO_0000059,
:obo/IAO_0000115
"A type of dementia which which the person meets the core clinical creteria for probable Alzheimer dementia.",
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "probable Alzheimer dementia"},
:rdfs/seeAlso "https://pubmed.ncbi.nlm.nih.gov/21514250/",
:rdfs/subClassOf :obo/ADO_0000050})
(def ADO_0000061
"impaired reasoning"
{:db/ident :obo/ADO_0000061,
:obo/IAO_0000115
"A symptom with which a patient may misunderstand the motives of the actions of their family, friends or others",
:obo/OGG_0000000030 true,
:obo/hasDbXref "https://pubmed.ncbi.nlm.nih.gov/21514250/",
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "impaired reasoning"},
:rdfs/subClassOf [{:owl/onProperty :obo/ADO_0000003,
:owl/someValuesFrom :obo/ADO_0000050,
:rdf/type :owl/Restriction}
:obo/ADO_0000001]})
(def ADO_0000062
"impaired language functions"
{:db/ident :obo/ADO_0000062,
:obo/IAO_0000115
"A symptom including defficulty thinking of common words while speaking, hesitations, speech, spelling, and writing errors.",
:obo/OGG_0000000030 true,
:obo/hasDbXref "https://pubmed.ncbi.nlm.nih.gov/21514250/",
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "impaired language functions"},
:rdfs/subClassOf [{:owl/onProperty :obo/ADO_0000003,
:owl/someValuesFrom :obo/ADO_0000050,
:rdf/type :owl/Restriction}
:obo/ADO_0000001]})
(def ADO_0000063
"insidious onset of dementia"
{:db/ident :obo/ADO_0000063,
:obo/IAO_0000115
"A stage where symptoms have a gradual onset over months to years but with harmful effects, not sudden within hours or days.",
:obo/hasDbXref "https://pubmed.ncbi.nlm.nih.gov/9546336/",
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "insidious onset of dementia"},
:rdfs/subClassOf [{:owl/onProperty :obo/ADO_0000003,
:owl/someValuesFrom :obo/ADO_0000059,
:rdf/type :owl/Restriction}
:obo/OBI_0000278]})
(def ADO_0000064
"amnestic symptom"
{:db/ident :obo/ADO_0000064,
:obo/IAO_0000115
"A symptom including impairment in learning and recalling of recently learned information, loss of memory, disorientation with time and space, lack of insight to their memory loss and being aware of their memory loss but not being able to understand why.",
:obo/hasDbXref
"https://hospitals.aku.edu/pakistan/diseases-and-conditions/Pages/amnestic-disorder.aspx",
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "amnestic symptom"},
:rdfs/subClassOf [{:owl/onProperty :obo/ADO_0000003,
:owl/someValuesFrom :obo/ADO_0000059,
:rdf/type :owl/Restriction}
:obo/ADO_0000001]})
(def ADO_0000065
"non-demented cognitive impairment"
{:db/ident :obo/ADO_0000065,
:obo/IAO_0000115
"A symptom that is sufficiently mild that there is no evidence of a significant impairment in social or occupational functioning.",
:obo/OGG_0000000030 true,
:obo/hasDbXref "https://pubmed.ncbi.nlm.nih.gov/21514249/",
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "non-demented cognitive impairment"},
:rdfs/subClassOf [{:owl/onProperty :obo/ADO_0000003,
:owl/someValuesFrom :obo/ADO_0000049,
:rdf/type :owl/Restriction}
:obo/ADO_0000001]})
(def ADO_0000066
"possible Alzheimer dementia"
{:db/ident :obo/ADO_0000066,
:obo/IAO_0000115
"A type of Alzheimer dementia whic meets core clinical criteria for possible Alzheimer dementia",
:obo/hasDbXref
"https://www.nia.nih.gov/health/alzheimers-disease-diagnostic-guidelines",
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "possible Alzheimer dementia"},
:rdfs/subClassOf :obo/ADO_0000050})
(def ADO_0000067
"sudden onset of cognitive impairment"
{:db/ident :obo/ADO_0000067,
:obo/IAO_0000115 "A stage where cognitive impiarment suddenly arises",
:obo/hasDbXref "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3331682/",
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "sudden onset of cognitive impairment"},
:rdfs/subClassOf [{:owl/onProperty :obo/ADO_0000003,
:owl/someValuesFrom :obo/ADO_0000066,
:rdf/type :owl/Restriction}
:obo/OBI_0000278]})
(def ADO_0000068
"asymptomatic cerebral amyloidosis"
{:db/ident :obo/ADO_0000068,
:obo/IAO_0000115
"A biological process by which an individual has biomarker evidence of amyloid-beta accumulation with elevated tracer retention on PET amyloid imaging and/or low amyloid-beta 42 in CSF assay, but no detectable evidence of additional brain alterations suggestive of neurodegeneration or subtle cognitive and/or behavioral symptomatology.",
:obo/OGG_0000000030 true,
:obo/hasDbXref "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3220946/",
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "asymptomatic cerebral amyloidosis"},
:rdfs/subClassOf [{:owl/onProperty :obo/ADO_0000003,
:owl/someValuesFrom :obo/ADO_0000048,
:rdf/type :owl/Restriction}
:obo/GO_0008150]})
(def ADO_0000069
"amyloid positivity"
{:db/ident :obo/ADO_0000069,
:obo/IAO_0000115
"A result from clinical assessment that characterizes presence of abnormal amyloid found with cerebrospinal fluid (CSF) and/or positron emission tomography (PET)",
:obo/hasDbXref "https://pubmed.ncbi.nlm.nih.gov/25713403/",
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "amyloid positivity"},
:rdfs/subClassOf [{:owl/onProperty :obo/ADO_0000006,
:owl/someValuesFrom :obo/DOID_10652,
:rdf/type :owl/Restriction}
:obo/CMO_0000000]})
(def ADO_0000070
"amyloid-beta 42/amyloid-beta 40 ratio"
{:db/ident :obo/ADO_0000070,
:obo/IAO_0000115
"A ratio between amyloid-beta 42 and amyloid-beta 40. Decreased ratio of amyloid-beta 42/40 is a strong marker of Alzheimer's disease.",
:obo/hasDbXref
"https://www.svarlifescience.com/services/wieslab-diagnostic-services/997-l-beta-amyloid-ratio-42-40#:~:text=Beta%20amyloid%2040%20is%20the,even%20before%20clinical%20dementia%20occurs.",
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "amyloid-beta 42/amyloid-beta 40 ratio"},
:rdfs/subClassOf [{:owl/onProperty :obo/ADO_0000006,
:owl/someValuesFrom :obo/DOID_10652,
:rdf/type :owl/Restriction}
:obo/STATO_0000184]})
(def ADO_0000071
"APOE genotype test"
{:Property/P1659 "https://www.mayocliniclabs.com/test-catalog/Overview/35358",
:db/ident :obo/ADO_0000071,
:obo/IAO_0000115
"A technique used to determine the specific apolipoprotein E (APOE) genotypes in patients with type III hyperlipoproteinemia",
:oboInOwl/hasExactSynonym ["Apolipoprotein E Genotyping" "APOE genotyping"],
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "APOE genotype test"},
:rdfs/subClassOf :obo/CMO_0000035})
(def ADO_0000072
"BACE1 inhibitor"
{:db/ident :obo/ADO_0000072,
:obo/IAO_0000115
"An inhibitor that interferes the chemical reaction of BACE1",
:oboInOwl/hasExactSynonym "beta-site APP cleaving enzyme 1 inhibitor",
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "BACE1 inhibitor"},
:rdfs/subClassOf :obo/CHEBI_23924})
(def ADO_0000073
"beta-secretase 1 measurement"
{:Property/P1659 "https://pubmed.ncbi.nlm.nih.gov/31745860/",
:db/ident :obo/ADO_0000073,
:obo/IAO_0000115
["Quantification of the amount of beta-secretase 1 in a sample, typicallly cerebrospinal fluid. Beta-secretase-1 is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells, and is thought to have a role in Alzheimer's disease pathogenesis."
"A measurement that quantifies the amount of beta-secretase 1 (BACE1) normally found in blood or cerebrospinal fluid. The quantification of the amount of beta-secretase 1 in a sample, typicallly cerebrospinal fluid. Beta-secretase-1 is an aspartic-acid protease important in the formation of myelin sheaths in peripheral nerve cells, and is thought to have a role in Alzheimer's disease pathogenesis."],
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "beta-secretase 1 measurement"},
:rdfs/subClassOf :obo/CMO_0000000})
(def ADO_0000074
"Brief Alzheimer Screen test"
{:db/ident :obo/ADO_0000074,
:obo/IAO_0000115
"A test developed from cognitive assessments on 406 normal subjects and 342 mild AD patients in the CERAD (Consortium to Establish a Registry for AD) dataset.",
:obo/OGG_0000000030 true,
:obo/hasDbXref "https://pubmed.ncbi.nlm.nih.gov/14646030/",
:oboInOwl/hasExactSynonym "BAS (Brief Alzheimer Screen) Screening Test",
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "Brief Alzheimer Screen test"},
:rdfs/subClassOf [{:owl/onProperty :obo/ADO_0000006,
:owl/someValuesFrom :obo/DOID_10652,
:rdf/type :owl/Restriction}
:obo/NCIT_C20993]})
(def ADO_0000075
"Cambridge Neuropsychological Test Automated Battery for Alzheimer disease"
{:db/ident :obo/ADO_0000075,
:obo/IAO_0000115
"A tool to assess cognitive functions in diverse neurological and psychiatric disorders, such as dementia, schizophrenia, depression, Parkinson's Disease.",
:obo/hasDbXref "https://pubmed.ncbi.nlm.nih.gov/16085791/",
:oboInOwl/hasExactSynonym "CANTAB-Alz",
:rdf/type :owl/Class,
:rdfs/label
{:rdf/language "de",
:rdf/value
"Cambridge Neuropsychological Test Automated Battery for Alzheimer disease"},
:rdfs/subClassOf [{:owl/onProperty :obo/ADO_0000006,
:owl/someValuesFrom :obo/DOID_10652,
:rdf/type :owl/Restriction}
:obo/NCIT_C20993]})
(def ADO_0000076
"caffeine consumption"
{:db/ident :obo/ADO_0000076,
:obo/IAO_0000115
"A behavior of consuming caffeine-containing products such as coffee, tea, cacao, energy drinks",
:obo/OGG_0000000030 true,
:obo/hasDbXref "https://pubmed.ncbi.nlm.nih.gov/8603790/",
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "caffeine consumption"},
:rdfs/subClassOf :obo/NCIT_C16795})
(def ADO_0000077
"DemTect screening test"
{:db/ident :obo/ADO_0000077,
:obo/IAO_0000115
"A tool used as a new 6-8 minute dementia screening, consisting of 5 short subtests, which is objective both in performance and evaluation.",
:obo/hasDbXref
"https://www.researchgate.net/publication/285702266_DemTect_A_new_screening_method_to_support_diagnosis_of_dementia",
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "DemTect screening test"},
:rdfs/subClassOf [{:owl/onProperty :obo/ADO_0000006,
:owl/someValuesFrom :obo/DOID_10652,
:rdf/type :owl/Restriction}
:obo/NCIT_C20993]})
(def ADO_0000079
"tobacco consumption"
{:db/ident :obo/ADO_0000079,
:obo/IAO_0000115 "A behavior of consuming tabacco products",
:obo/hasDbXref
"https://www.alzheimers.org.uk/about-dementia/risk-factors-and-prevention/smoking-and-dementia#:~:text=It%20is%20known%20that%20smoking,the%20development%20of%20Alzheimer's%20disease.",
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "tobacco consumption"},
:rdfs/subClassOf :obo/NCIT_C16795})
(def ADO_0000080
"Everyday Cognition questionnaire"
{:db/ident :obo/ADO_0000080,
:obo/IAO_0000115
"A questionnaire comprised of multiple subscales evaluating everyday cognitive function",
:obo/OGG_0000000030 true,
:obo/hasDbXref "https://pubmed.ncbi.nlm.nih.gov/18590364/",
:oboInOwl/hasExactSynonym "Ecog questionnaire",
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "Everyday Cognition questionnaire"},
:rdfs/subClassOf [{:owl/onProperty :obo/ADO_0000006,
:owl/someValuesFrom :obo/DOID_10652,
:rdf/type :owl/Restriction}
:obo/NCIT_C91105]})
(def ADO_0000081
"Global Deterioration Scale"
{:db/ident :obo/ADO_0000081,
:obo/IAO_0000115
"A method used for assessment of primary degenerative dementia and delineation of its stages",
:obo/OGG_0000000030 true,
:obo/hasDbXref "https://pubmed.ncbi.nlm.nih.gov/7114305/",
:oboInOwl/hasExactSynonym "GDS scale",
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "Global Deterioration Scale"},
:rdfs/subClassOf [{:owl/onProperty :obo/ADO_0000006,
:owl/someValuesFrom :obo/DOID_10652,
:rdf/type :owl/Restriction}
:obo/NCIT_C20993]})
(def ADO_0000082
"traumatic brain injury"
{:db/ident :obo/ADO_0000082,
:obo/IAO_0000115
"Traumatic brain injury usually results from a violent blow or jolt to the head or body. An object that goes through brain tissue, such as a bullet or shattered piece of skull, also can cause traumatic brain injury.",
:obo/hasDbXref
"https://www.mayoclinic.org/diseases-conditions/traumatic-brain-injury/symptoms-causes/syc-20378557",
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "traumatic brain injury"},
:rdfs/subClassOf [{:owl/onProperty :obo/ADO_0000004,
:owl/someValuesFrom :obo/DOID_10652,
:rdf/type :owl/Restriction}
:obo/DOID_7]})
(def ADO_0000083
"Inability to communicate"
{:db/ident :obo/ADO_0000083,
:obo/IAO_0000115 "A symptom of failure to communicate with others.",
:obo/hasDbXref "https://pubmed.ncbi.nlm.nih.gov/23522497/",
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "Inability to communicate"},
:rdfs/subClassOf :obo/ADO_0000001})
(def ADO_0000084
"Inability to recognize oneself or family"
{:db/ident :obo/ADO_0000084,
:obo/IAO_0000115
"A cognitive symptom of failure to recognize oneself's or family member's identity",
:obo/hasDbXref "https://pubmed.ncbi.nlm.nih.gov/22553492/",
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "Inability to recognize oneself or family"},
:rdfs/subClassOf :obo/ADO_0000001})
(def ADO_0000085
"Memory Orientation Screening Test"
{:db/ident :obo/ADO_0000085,
:obo/IAO_0000115
"A test that separates normal from MCI and demented elders in a prevalence-stratified sample",
:obo/hasDbXref
"https://www.omicsonline.org/the-memory-orientation-screening-test-most-accurately-separates-normal-from-mci-and-demented-elders-in-a-prevalence-stratified-sample-2161-0460.1000109.php?aid=11372",
:oboInOwl/hasExactSynonym "MOST test",
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "Memory Orientation Screening Test"},
:rdfs/subClassOf [{:owl/onProperty :obo/ADO_0000006,
:owl/someValuesFrom :obo/DOID_10652,
:rdf/type :owl/Restriction}
:obo/NCIT_C20993]})
(def ADO_0000086
"Neurobehavioral Cognitive Status Examination"
{:db/ident :obo/ADO_0000086,
:obo/IAO_0000115
"A screening examination that assesses cognition in a brief but quantitative fashion, uses independent tests to evaluate functioning within five major cognitive ability areas: language, constructions, memory, calculations, and reasoning.",
:obo/OGG_0000000030 true,
:obo/hasDbXref "https://pubmed.ncbi.nlm.nih.gov/3631786/",
:oboInOwl/hasExactSynonym "NCSE",
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "Neurobehavioral Cognitive Status Examination"},
:rdfs/subClassOf [{:owl/onProperty :obo/ADO_0000006,
:owl/someValuesFrom :obo/DOID_10652,
:rdf/type :owl/Restriction}
:obo/NCIT_C20993]})
(def ADO_0000088
"Short Portable Mental Status Questionnaire (SPMSQ)"
{:db/ident :obo/ADO_0000088,
:obo/IAO_0000115
"A questionaire with 10 items that can be easily administered by clinicians in mental impairment diagnosis",
:obo/OGG_0000000030 true,
:obo/hasDbXref "https://pubmed.ncbi.nlm.nih.gov/1159263/",
:oboInOwl/hasExactSynonym "SPMSQ",
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value
"Short Portable Mental Status Questionnaire (SPMSQ)"},
:rdfs/subClassOf [{:owl/onProperty :obo/ADO_0000006,
:owl/someValuesFrom :obo/DOID_10652,
:rdf/type :owl/Restriction}
:obo/NCIT_C91105]})
(def ADO_0000089
"Xiusanzhen"
{:db/ident :obo/ADO_0000089,
:obo/IAO_0000115
"An acupuncture method that involves pucture at bilateral Yingxiang and Yintang points",
:obo/OGG_0000000030 true,
:obo/hasDbXref "https://pubmed.ncbi.nlm.nih.gov/21717774/",
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "Xiusanzhen"},
:rdfs/subClassOf :obo/OAE_0000002})
(def ADO_0000090
"total tau"
{:db/ident :obo/ADO_0000090,
:obo/IAO_0000115
"A protein that is regarded as a general marker of neurodegeneration for evaluation in future population-based studies and represents the total tau concentration in a given sample.",
:obo/hasDbXref "https://pubmed.ncbi.nlm.nih.gov/15178952/",
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "total tau"},
:rdfs/subClassOf :obo/PR_000000001})
(def ADO_0000091
"phosphorylated tau"
{:db/ident :obo/ADO_0000091,
:obo/IAO_0000115
"A protein that is phosphorylated through post-translational modification. Its accumulation reflects the formation of neurofibrillary tangles, synaptic impairment, and neuronal dysfunction.",
:obo/hasDbXref "https://pubmed.ncbi.nlm.nih.gov/32812023/",
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "phosphorylated tau"},
:rdfs/subClassOf :obo/PR_000000001})
(def ADO_0000092
"insulin signalling"
{:db/ident :obo/ADO_0000092,
:obo/IAO_0000115
"a signaling process that is initiated through binding and activation of its cell-surface receptor and initiates a cascade of phosphorylation and dephosphorylation events, second-messenger generation, and protein-protein interactions that result in diverse metabolic events in almost every tissue",
:obo/hasDbXref
"https://www.sciencedirect.com/topics/biochemistry-genetics-and-molecular-biology/insulin-signaling",
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "insulin signalling"},
:rdfs/subClassOf :obo/GO_0023052})
(def ADO_0000093
"neurotrophic signalling"
{:db/ident :obo/ADO_0000093,
:obo/IAO_0000115
"A signaling process through which neurotrophins modulate long-term potentiation, dendritic complexity and axon branching, processes that promote synaptic efficacy and thus learning and memory.",
:obo/OGG_0000000030 true,
:obo/hasDbXref "https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5295469/",
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "neurotrophic signalling"},
:rdfs/subClassOf :obo/GO_0023052})
(def ADO_0000094
"phospatidylinositol signalling"
{:db/ident :obo/ADO_0000094,
:obo/IAO_0000115
"An internal signaling process in response to extracellular signals through which phosphatidylinositols undergo rapid turnover and generate second messengers including diacylglycerol, inositol 1,4,5-trisphosphate, phosphatidylinositol 3,4-bisphosphate (PtdIns 3,4P2) and phosphatidylinositol 3,4,5-trisphosphate.",
:obo/hasDbXref "https://pubmed.ncbi.nlm.nih.gov/9599410",
:rdf/type :owl/Class,
:rdfs/label {:rdf/language "de",
:rdf/value "phospatidylinositol signalling"},
:rdfs/subClassOf :obo/GO_0023052})
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