contract.js

const accounts = await web3.eth.getAccounts();
const instance = new web3.eth.Contract(ABI,address)
instance.methods.functionName(params).send({
     from: accounts[0],
     gas: '1000000'
});

const accounts = await web3.eth.getAccounts();
const instance = new web3.eth.Contract(ABI,address)
// cal the set 
instance.methods.set("Hello").send({
     from: accounts[0],
     gas: '1000000'
});

// call the get
const message = instance.methods.get().call();