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Sample pathvisiojs data model. It uses "connector" to refer to GPML elements of type Interaction and GraphicalLine, and it uses "div" in the HTML sense to indicate elements that should be rendered as containers. These divs are used for GPML elements of type Group, DataNode, Label and Shape. Just as in HTML, divs can contain child elements. In or…
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| <?xml version="1.0" encoding="UTF-8"?> | |
| <Pathway xmlns="http://pathvisio.org/GPML/2013a" Name="Fluoropyrimidine Activity" Organism="Homo sapiens" License="CC BY 2.0"> | |
| <Comment Source="WikiPathways-description">The main mechanism of 5-FU activation is conversion to fluorodeoxyuridine monophosphate (FdUMP) which inhibits the enzyme thymidylate synthase (TYMS), an important part of the folate-homocysteine cycle and purine and pyrimidine synthesis The conversion of 5-FU to FdUMP can occur via thymidylate phosphorylase (TYMP) to fluorodeoxyuridine (FUDR) and then by the action of thymidine kinase to FdUMP or indirectly via fluorouridine monophosphate (FUMP) or fluroridine (FUR) to fluorouridine diphosphate (FUDP) and then ribonucleotide reductase action to FdUDP and FdUMP. FUDP and FdUDP can also be converted to FUTP and FdUTP and incorporated into RNA and DNA respectively which also contributes to the pharmacodynamic actions of fluoropyrimidines. | |
| Sources: [http://www.pharmgkb.org/do/serve?objId=PA150653776&objCls=Pathway PharmGKB:Fluoropyrimidine Pharmacokinetics], [http://www.pharmgkb.org/do/serve?objId=PA165291507&objCls=Pathway PharmGKB:Fluoropyrimidine Pharmacodynamics], [http://en.wikipedia.org/wiki/Fluorouracil Wikipedia:Fluorouracil]</Comment> | |
| <Comment Source="WikiPathways-category">Metabolic Process</Comment> | |
| <Comment Source="WikiPathways-category">Cellular Process</Comment> | |
| <BiopaxRef>a3c</BiopaxRef> | |
| <BiopaxRef>f20</BiopaxRef> | |
| <BiopaxRef>a45</BiopaxRef> | |
| <BiopaxRef>a42</BiopaxRef> | |
| <BiopaxRef>bf9</BiopaxRef> | |
| <BiopaxRef>b9d</BiopaxRef> | |
| <BiopaxRef>b66</BiopaxRef> | |
| <BiopaxRef>b8e</BiopaxRef> | |
| <BiopaxRef>dd6</BiopaxRef> | |
| <BiopaxRef>d42</BiopaxRef> | |
| <BiopaxRef>fa0</BiopaxRef> | |
| <BiopaxRef>d3c</BiopaxRef> | |
| <Graphics BoardWidth="587.0637475853184" BoardHeight="567.0427530915014" /> | |
| <DataNode TextLabel="FUDP" GraphId="fudpabc" Type="Metabolite"> | |
| <Graphics CenterX="182.75420428593074" CenterY="233.74251308841764" Width="39.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> | |
| <Xref Database="" ID="" /> | |
| </DataNode> | |
| <DataNode TextLabel="FUTP" GraphId="futpabc" Type="Metabolite"> | |
| <Graphics CenterX="182.03088815969042" CenterY="339.2321115552345" Width="39.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> | |
| <Xref Database="Chemspider" ID="8430967" /> | |
| </DataNode> | |
| <DataNode TextLabel="FdUDP
Llp" GraphId="fdudpllpabc" Type="Metabolite"> | |
| <Graphics CenterX="364.8383629860658" CenterY="342.724412662856" Width="39.0" Height="32.97788694428051" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" /> | |
| <Xref Database="" ID="" /> | |
| </DataNode> | |
| <DataNode TextLabel="RRM1" GraphId="rrmabc" Type="GeneProduct" GroupRef="pathwayabc"> | |
| <Graphics CenterX="54.43419320794081" CenterY="239.6136144454081" Width="44.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> | |
| <Xref Database="Entrez Gene" ID="6240" /> | |
| </DataNode> | |
| <DataNode TextLabel="RRM2" GraphId="rrmbcd" Type="GeneProduct" GroupRef="pathwayabc"> | |
| <Graphics CenterX="54.43419320794081" CenterY="317.41708265350064" Width="44.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" /> | |
| <Xref Database="Entrez Gene" ID="6241" /> | |
| </DataNode> | |
| <DataNode TextLabel="INH1" GraphId="inhabc" Type="GeneProduct" GroupRef="complexabc"> | |
| <Graphics CenterX="123.24372922681886" CenterY="164.0754719510392" Width="33.548616039744516" Height="20.0" ZOrder="32769" FontSize="10" Valign="Middle" /> | |
| <Xref Database="" ID="" /> | |
| </DataNode> | |
| <DataNode TextLabel="INH2" GraphId="inhbcd" Type="GeneProduct" GroupRef="complexabc"> | |
| <Graphics CenterX="123.24372922681886" CenterY="188.26993611001726" Width="33.548616039744516" Height="20.0" ZOrder="32770" FontSize="10" Valign="Middle" /> | |
| <Xref Database="" ID="" /> | |
| </DataNode> | |
| <Interaction GraphId="edgebcd"> | |
| <Graphics ZOrder="12288" LineThickness="1.0"> | |
| <Point X="182.75420428593074" Y="243.74251308841764" GraphRef="fudpabc" RelX="0.0" RelY="1.0" /> | |
| <Point X="182.03088815969042" Y="329.2321115552345" GraphRef="futpabc" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" /> | |
| <Anchor Position="0.4" Shape="None" GraphId="b6bd7" /> | |
| </Graphics> | |
| <Xref Database="" ID="" /> | |
| </Interaction> | |
| <Interaction GraphId="edgeefg"> | |
| <Graphics ConnectorType="Elbow" ZOrder="12288" LineThickness="1.0"> | |
| <Point X="182.75420428593074" Y="243.74251308841764" GraphRef="fudpabc" RelX="0.0" RelY="1.0" /> | |
| <Point X="364.8383629860658" Y="326.2354691907158" GraphRef="fdudpllpabc" RelX="0.0" RelY="-1.0" ArrowHead="mim-conversion" /> | |
| </Graphics> | |
| <Xref Database="" ID="" /> | |
| </Interaction> | |
| <Interaction GraphId="edgecde"> | |
| <Graphics ZOrder="12288" LineThickness="1.0"> | |
| <Point X="84.43419320794081" Y="278.51534854945436" GraphRef="e3223" RelX="1.0" RelY="0.0" /> | |
| <Point X="182.4648778354346" Y="277.93835247514437" GraphRef="b6bd7" RelX="0.0" RelY="0.0" ArrowHead="mim-catalysis" /> | |
| <Anchor Position="0.4" Shape="Circle" GraphId="a1e7c" /> | |
| </Graphics> | |
| <Xref Database="" ID="" /> | |
| </Interaction> | |
| <Interaction GroupRef="pathwayabc"> | |
| <Graphics ZOrder="12288" LineThickness="1.0"> | |
| <Point X="54.43419320794081" Y="249.6136144454081" GraphRef="rrmabc" RelX="0.0" RelY="1.0" ArrowHead="Arrow" /> | |
| <Point X="54.43419320794081" Y="307.41708265350064" GraphRef="rrmbcd" RelX="0.0" RelY="-1.0" ArrowHead="Arrow" /> | |
| </Graphics> | |
| <Xref Database="" ID="" /> | |
| </Interaction> | |
| <Interaction> | |
| <Graphics ZOrder="12288" LineThickness="1.0"> | |
| <Point X="123.24372922681886" Y="210.26993611001726" GraphRef="a25de" RelX="0.0" RelY="1.0" /> | |
| <Point X="123.64646705893833" Y="278.28455011973034" GraphRef="a1e7c" RelX="0.0" RelY="0.0" ArrowHead="TBar" /> | |
| </Graphics> | |
| <Xref Database="" ID="" /> | |
| </Interaction> | |
| <GraphicalLine> | |
| <Graphics ZOrder="12288" LineThickness="1.0" Color="ff3333"> | |
| <Point X="211.60590239653925" Y="147.36532007575642" GraphRef="myannotationabc" RelX="-1.0" RelY="0.0" /> | |
| <Point X="152.0180372466911" Y="176.17270403052822" GraphRef="a25de" RelX="1.0" RelY="0.0" ArrowHead="Arrow" /> | |
| </Graphics> | |
| </GraphicalLine> | |
| <GraphicalLine> | |
| <Graphics ZOrder="12288" LineThickness="1.0" Color="33ff33"> | |
| <Point X="251.60590239653925" Y="137.36532007575642" GraphRef="myannotationabc" RelX="0.0" RelY="-1.0" /> | |
| <Point X="200.73661714219296" Y="70.09551968940724" ArrowHead="Arrow" /> | |
| </Graphics> | |
| </GraphicalLine> | |
| <Label TextLabel="my annotation" GraphId="myannotationabc"> | |
| <Graphics CenterX="251.60590239653922" CenterY="147.36532007575642" Width="80.0" Height="20.0" ZOrder="28672" FillColor="ffffff" FontSize="10" Valign="Middle" /> | |
| </Label> | |
| <Group GroupId="pathwayabc" GraphId="e3223" Style="Pathway" TextLabel="My Pathway" /> | |
| <Group GroupId="complexabc" GraphId="a25de" Style="Complex" /> | |
| <InfoBox CenterX="0.0" CenterY="0.0" /> | |
| <Biopax> | |
| <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="b66"> | |
| <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">19302291</bp:ID> | |
| <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> | |
| <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Down-regulation of cIAP2 enhances 5-FU sensitivity through the apoptotic pathway in human colon cancer cells.</bp:TITLE> | |
| <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cancer Sci</bp:SOURCE> | |
| <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2009</bp:YEAR> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Karasawa H</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Miura K</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fujibuchi W</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ishida K</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kaneko N</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kinouchi M</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Okabe M</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ando T</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Murata Y</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sasaki H</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Takami K</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Yamamura A</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Shibata C</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sasaki I</bp:AUTHORS> | |
| </bp:PublicationXref> | |
| <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"> | |
| <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">cancer</bp:TERM> | |
| <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOID:162</bp:ID> | |
| <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Disease</bp:Ontology> | |
| </bp:openControlledVocabulary> | |
| <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ad5"> | |
| <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">19093176</bp:ID> | |
| <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> | |
| <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Predicting clinical outcome of 5-fluorouracil-based chemotherapy for colon cancer patients: is the CpG island methylator phenotype the 5-fluorouracil-responsive subgroup?</bp:TITLE> | |
| <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Int J Clin Oncol</bp:SOURCE> | |
| <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2008</bp:YEAR> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Iacopetta B</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kawakami K</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Watanabe T</bp:AUTHORS> | |
| </bp:PublicationXref> | |
| <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="bf9"> | |
| <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">15548681</bp:ID> | |
| <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> | |
| <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mechanistic and predictive profiling of 5-Fluorouracil resistance in human cancer cells.</bp:TITLE> | |
| <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cancer Res</bp:SOURCE> | |
| <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2004</bp:YEAR> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wang W</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cassidy J</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">O'Brien V</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ryan KM</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Collie-Duguid E</bp:AUTHORS> | |
| </bp:PublicationXref> | |
| <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="f96"> | |
| <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">17549067</bp:ID> | |
| <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> | |
| <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pharmacogenetic profiling in patients with advanced colorectal cancer treated with first-line FOLFIRI chemotherapy.</bp:TITLE> | |
| <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pharmacogenomics J</bp:SOURCE> | |
| <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2008</bp:YEAR> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ruzzo A</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Graziano F</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Loupakis F</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Santini D</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Catalano V</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Bisonni R</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ficarelli R</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Fontana A</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Andreoni F</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Falcone A</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Canestrari E</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tonini G</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mari D</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lippe P</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pizzagalli F</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Schiavon G</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Alessandroni P</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Giustini L</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Maltese P</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Testa E</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Menichetti ET</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Magnani M</bp:AUTHORS> | |
| </bp:PublicationXref> | |
| <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ffd"> | |
| <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">11956089</bp:ID> | |
| <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> | |
| <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Uridine phosphorylase (-/-) murine embryonic stem cells clarify the key role of this enzyme in the regulation of the pyrimidine salvage pathway and in the activation of fluoropyrimidines.</bp:TITLE> | |
| <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cancer Res</bp:SOURCE> | |
| <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2002</bp:YEAR> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cao D</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Russell RL</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Zhang D</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Leffert JJ</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pizzorno G</bp:AUTHORS> | |
| </bp:PublicationXref> | |
| <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a64"> | |
| <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">18498133</bp:ID> | |
| <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> | |
| <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway based analysis of SNPs with relevance to 5-FU therapy: relation to intratumoral mRNA expression and survival.</bp:TITLE> | |
| <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Int J Cancer</bp:SOURCE> | |
| <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2008</bp:YEAR> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Nordgard SH</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Alnaes GI</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Hihn B</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lingjaerde OC</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Liestøl K</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Tsalenko A</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Sørlie T</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Lønning PE</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Børresen-Dale AL</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Kristensen VN</bp:AUTHORS> | |
| </bp:PublicationXref> | |
| <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="ff5"> | |
| <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">15638735</bp:ID> | |
| <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> | |
| <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Novel chemical strategies for thymidylate synthase inhibition.</bp:TITLE> | |
| <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Curr Med Chem</bp:SOURCE> | |
| <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2005</bp:YEAR> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Gmeiner WH</bp:AUTHORS> | |
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| </bp:PublicationXref> | |
| <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="d5d"> | |
| <bp:ID rdf:datatype="http://www.w3.org/2001/XMLSchema#string">18837291</bp:ID> | |
| <bp:DB rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PubMed</bp:DB> | |
| <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Breast cancer resistance protein expression and 5-fluorouracil resistance.</bp:TITLE> | |
| <bp:SOURCE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Biomed Environ Sci</bp:SOURCE> | |
| <bp:YEAR rdf:datatype="http://www.w3.org/2001/XMLSchema#string">2008</bp:YEAR> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Yuan JH</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Cheng JQ</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Jiang LY</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Ji WD</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Guo LF</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Liu JJ</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Xu XY</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">He JS</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Wang XM</bp:AUTHORS> | |
| <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Zhuang ZX</bp:AUTHORS> | |
| </bp:PublicationXref> | |
| </Biopax> | |
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| "id":"fdudpllpabc-anchor5", | |
| "relX":1, | |
| "relY":0 | |
| }, | |
| { | |
| "id":"fdudpllpabc-anchor6", | |
| "relX":1, | |
| "relY":0.5 | |
| }, | |
| { | |
| "id":"fdudpllpabc-anchor7", | |
| "relX":0.5, | |
| "relY":1 | |
| }, | |
| { | |
| "id":"fdudpllpabc-anchor8", | |
| "relX":0, | |
| "relY":1 | |
| }, | |
| { | |
| "id":"fdudpllpabc-anchor9", | |
| "relX":-0.5, | |
| "relY":1 | |
| }, | |
| { | |
| "id":"fdudpllpabc-anchor10", | |
| "relX":-1, | |
| "relY":0.5 | |
| }, | |
| { | |
| "id":"fdudpllpabc-anchor11", | |
| "relX":-1, | |
| "relY":0 | |
| }, | |
| { | |
| "id":"fdudpllpabc-anchor12", | |
| "relX":-1, | |
| "relY":-0.5 | |
| } | |
| ], | |
| "style":{ | |
| "backgroundImage":{ | |
| "shapeId":"rectangle", | |
| "style":{ | |
| "fill":"#ffffff", | |
| "stroke":"blue" | |
| } | |
| }, | |
| "font":"Arial", | |
| "fontSize":"10", | |
| "color":"blue" | |
| }, | |
| "textContent":"FdUDP\nLlp" | |
| }, | |
| { | |
| "id":"myannotationabc", | |
| "graphicalType":"div", | |
| "gpmlType":"Label", | |
| "anchors":[ | |
| { | |
| "id":"myannotationabc-anchor1", | |
| "relX":-0.5, | |
| "relY":-1 | |
| }, | |
| { | |
| "id":"myannotationabc-anchor2", | |
| "relX":0, | |
| "relY":-1 | |
| }, | |
| { | |
| "id":"myannotationabc-anchor3", | |
| "relX":0.5, | |
| "relY":-1 | |
| }, | |
| { | |
| "id":"myannotationabc-anchor4", | |
| "relX":1, | |
| "relY":-0.5 | |
| }, | |
| { | |
| "id":"myannotationabc-anchor5", | |
| "relX":1, | |
| "relY":0 | |
| }, | |
| { | |
| "id":"myannotationabc-anchor6", | |
| "relX":1, | |
| "relY":0.5 | |
| }, | |
| { | |
| "id":"myannotationabc-anchor7", | |
| "relX":0.5, | |
| "relY":1 | |
| }, | |
| { | |
| "id":"myannotationabc-anchor8", | |
| "relX":0, | |
| "relY":1 | |
| }, | |
| { | |
| "id":"myannotationabc-anchor9", | |
| "relX":-0.5, | |
| "relY":1 | |
| }, | |
| { | |
| "id":"myannotationabc-anchor10", | |
| "relX":-1, | |
| "relY":0.5 | |
| }, | |
| { | |
| "id":"myannotationabc-anchor11", | |
| "relX":-1, | |
| "relY":0 | |
| }, | |
| { | |
| "id":"myannotationabc-anchor12", | |
| "relX":-1, | |
| "relY":-0.5 | |
| } | |
| ], | |
| "style":{ | |
| "font":"Arial", | |
| "fontSize":"10", | |
| "color":"black" | |
| }, | |
| "textContent":"my annotation" | |
| }, | |
| { | |
| "id": "edgebcd", | |
| "graphicalType":"connector", | |
| "gpmlType":"Interaction", | |
| "semanticType":"none,arrow", | |
| "anchors":[ | |
| { | |
| "id":"edgebcd-anchor1", | |
| "position":0.5 | |
| } | |
| ], | |
| "points":{ | |
| "specified":[ | |
| { | |
| "type":"anchor", | |
| "anchorId":"fudpabc-anchor2" | |
| }, | |
| { | |
| "type":"anchor", | |
| "anchorId":"futpabc-anchor2" | |
| } | |
| ], | |
| "cached":[ | |
| { | |
| "x":50, | |
| "y":100 | |
| }, | |
| { | |
| "x":20, | |
| "y":50 | |
| } | |
| ] | |
| }, | |
| "style":{ | |
| "stroke":"#000000" | |
| }, | |
| "connectorGraph": | |
| [ | |
| { | |
| "id": "fudpabc", | |
| "interactsWith": "futpabc" | |
| } | |
| ] | |
| }, | |
| { | |
| "id": "edgecde", | |
| "graphicalType":"connector", | |
| "gpmlType":"Interaction", | |
| "semanticType":"none,mim-catalysis", | |
| "anchors":[ | |
| { | |
| "id":"edgecde-anchor1", | |
| "position":0.5, | |
| "backgroundImage":{ | |
| "shapeId":"ellipse", | |
| "style":{ | |
| "fill":"#ffffff", | |
| "stroke":"blue" | |
| } | |
| } | |
| } | |
| ], | |
| "points":{ | |
| "specified":[ | |
| { | |
| "type":"anchor", | |
| "anchorId":"pathwayabc-anchor2" | |
| }, | |
| { | |
| "type":"anchor", | |
| "anchorId":"edgebcd-anchor2" | |
| } | |
| ], | |
| "cached":[ | |
| { | |
| "x":50, | |
| "y":100 | |
| }, | |
| { | |
| "x":20, | |
| "y":50 | |
| } | |
| ] | |
| }, | |
| "style":{ | |
| "stroke":"#000000" | |
| }, | |
| "connectorGraph": | |
| [ | |
| { | |
| "id": "pathwayabc", | |
| "interactsWith": "edgebcd" | |
| } | |
| ] | |
| }, | |
| { | |
| "id": "edgedef", | |
| "graphicalType":"connector", | |
| "gpmlType":"Interaction", | |
| "semanticType":"none,tbar", | |
| "points":{ | |
| "specified":[ | |
| { | |
| "type":"anchor", | |
| "anchorId":"myannotationabc-anchor2" | |
| }, | |
| { | |
| "type":"anchor", | |
| "anchorId":"edgecde-anchor1" | |
| } | |
| ], | |
| "cached":[ | |
| { | |
| "x":50, | |
| "y":100 | |
| }, | |
| { | |
| "x":20, | |
| "y":50 | |
| } | |
| ] | |
| }, | |
| "style":{ | |
| "stroke":"#000000" | |
| }, | |
| "connectorGraph": | |
| [ | |
| { | |
| "id": "complexabc", | |
| "interactsWith": "edgecde" | |
| } | |
| ] | |
| }, | |
| { | |
| "id": "edgeefg", | |
| "graphicalType":"connector", | |
| "gpmlType":"Interaction", | |
| "semanticType":"none,arrow", | |
| "points":{ | |
| "specified":[ | |
| { | |
| "type":"anchor", | |
| "anchorId":"fudpabc-anchor2" | |
| }, | |
| { | |
| "type":"anchor", | |
| "anchorId":"fdudpllpabc-anchor2" | |
| } | |
| ], | |
| "cached":[ | |
| { | |
| "x":50, | |
| "y":100 | |
| }, | |
| { | |
| "x":50, | |
| "y":110 | |
| }, | |
| { | |
| "x":80, | |
| "y":110 | |
| }, | |
| { | |
| "x":80, | |
| "y":140 | |
| } | |
| ] | |
| }, | |
| "style":{ | |
| "stroke":"#000000" | |
| }, | |
| "connectorGraph": | |
| [ | |
| { | |
| "id": "fudpabc", | |
| "interactsWith": "fdudpllpabc" | |
| } | |
| ] | |
| }, | |
| { | |
| "id": "edgefgh", | |
| "graphicalType":"connector", | |
| "gpmlType":"GraphicalLine", | |
| "semanticType":"none,arrow", | |
| "points":{ | |
| "specified":[ | |
| { | |
| "type":"anchor", | |
| "anchorId":"myannotationabc-anchor2" | |
| }, | |
| { | |
| "type":"anchor", | |
| "anchorId":"complexabc-anchor2" | |
| } | |
| ], | |
| "cached":[ | |
| { | |
| "x":50, | |
| "y":100 | |
| }, | |
| { | |
| "x":20, | |
| "y":50 | |
| } | |
| ] | |
| }, | |
| "style":{ | |
| "stroke":"red" | |
| }, | |
| "connectorGraph": | |
| [ | |
| { | |
| "id": "myannotationabc", | |
| "interactsWith":"complexabc" | |
| } | |
| ] | |
| }, | |
| { | |
| "id": "edgefgh", | |
| "graphicalType":"connector", | |
| "gpmlType":"GraphicalLine", | |
| "semanticType":"none,arrow", | |
| "points":{ | |
| "specified":[ | |
| { | |
| "type":"anchor", | |
| "anchorId":"myannotationabc-anchor2" | |
| }, | |
| { | |
| "type":"point", | |
| "x":20, | |
| "y":50 | |
| } | |
| ], | |
| "cached":[ | |
| { | |
| "x":50, | |
| "y":100 | |
| }, | |
| { | |
| "x":20, | |
| "y":50 | |
| } | |
| ] | |
| }, | |
| "style":{ | |
| "stroke":"green" | |
| }, | |
| "connectorGraph": | |
| [ | |
| { | |
| "id": "myannotationabc", | |
| "interactsWith":null | |
| } | |
| ] | |
| } | |
| ] | |
| } |
Author
OK. I'd like to walkthrough this with you tomorrow and see just how different it is than our current model. I cautious about treating this refactor as an opportunity to improve on work that is just fine as is.
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Let's try to follow Google's JSON styleguide.