Security settings for WeeChat

README.md

Strongly Recommended

Disable DCC

/plugin unload xfer
/set weechat.plugin.autoload *,!xfer

Disable CTCP

/set irc.ctcp.action ""
/set irc.ctcp.clientinfo ""
/set irc.ctcp.finger ""
/set irc.ctcp.ping ""
/set irc.ctcp.source ""
/set irc.ctcp.time ""
/set irc.ctcp.userinfo ""
/set irc.ctcp.version ""

Remove WeeChat version part/quit messages

/set irc.server_default.default_msg_part ""
/set irc.server_default.default_msg_quit ""

Save your settings

/save

Optional

Prevent bot private message spam on Freenode and OFTC

/mode <nick> -G+g

@atoponce, thanks for the summary.
It seems some names changed in newer WeeChat versions:

-/set irc.server_default.default_msg_part ""
+/set irc.server_default.msg_part ""
-/set irc.server_default.default_msg_quit ""
+/set irc.server_default.msg_quit ""

Good comment by nyov. It helped.