An AppleScript for running a Wine application as a macOS application. Save as an Application in "Script Editor"

SpritePad.app

on run
	set toRun to "$HOME/.wine/drive_c/Program Files/SpritePad v2b1/SpritePad.exe"
	set winePrefix to "$HOME/.wine"
	set wineLocation to "/usr/local/bin"
	set dyldFallbackLibraryPath to "/opt/X11/lib"
	set freetypefix to "truetype:interpreter-version=35"
	set toRunPath to do shell script "WINEPREFIX=\"" & winePrefix & "\"; TEMPVAR=\"" & toRun & "\"; echo \"${TEMPVAR%/*}\""
	set toRunFile to do shell script "WINEPREFIX=\"" & winePrefix & "\"; TEMPVAR=\"" & toRun & "\"; TEMPVAR2=\"" & toRunPath & "\"; echo \"${TEMPVAR#$TEMPVAR2/}\""
	do shell script "PATH=\"" & wineLocation & ":$PATH\"; export WINEPREFIX=\"" & winePrefix & "\"; export DYLD_FALLBACK_LIBRARY_PATH=\"" & dyldFallbackLibraryPath & "\"; export FREETYPE_PROPERTIES=\"" & freetypefix & "\"; cd \"" & toRunPath & "\"; wine \"" & toRunFile & "\" > /dev/null 2>&1 &"
end run