Example of how to sign an API Gateway request using Signature Version 4 IAM-based authentication

requirements.txt

requests~=2.24.0
boto3~=1.16.5
aws_requests_auth~=0.4.3

submit-signed-rpc-request.py

import requests
import json
from aws_requests_auth.boto_utils import BotoAWSRequestsAuth

host = 'e1xffaj8ek.execute-api.us-east-1.amazonaws.com' # replace with your API host
endpoint = 'https://{}'.format(host) # add any additional path URI to the end of this string, if your API endpoint uses them
session = requests.Session()

# this call expects environment variables AWS_ACCESS_KEY_ID and AWS_SECRET_ACCESS_KEY
# (and optionally AWS_SESSION_TOKEN if you are using temporary credentials) to be set
auth = BotoAWSRequestsAuth(
    aws_host=host,
    aws_region='us-east-1',
    aws_service='execute-api'
)
payload = {
    "jsonrpc": "2.0",
    "method": "web3_clientVersion",
    "params": [],
    "id": 67
}

response = json.dumps(session.post(endpoint, auth=auth, json=payload).json(), indent=4)
print(response)