gistfile1.txt

$ python        
Python 3.7.0 (default, Jun 27 2018, 14:40:03) 
[GCC 8.1.0] on linux
Type "help", "copyright", "credits" or "license" for more information.
>>> print(open("testme.md").read())
# Hello World

Example:

  >>> 2 + 2
  4

Faling example:

  >>> 2 + 2
  3

>>>
>>> import doctest
>>> doctest.testfile("testme.md")
**********************************************************************
File "./testme.md", line 10, in testme.md
Failed example:
    2 + 2
Expected:
    3
Got:
    4
**********************************************************************
1 items had failures:
   1 of   2 in testme.md
***Test Failed*** 1 failures.
TestResults(failed=1, attempted=2)