Offload-Helper-MU-example.php

<?php
/**
 * Plugin Name: Offload API Helper
 * Plugin URI:  iwritecode.blog
 * Description: Offload plugins during API requests to reduce overhead.
 * Author:      Chris Kelley
 * Author URI:  iwritecode.blog
 * Version:     1.0.0
 */

$request_uri = parse_url( $_SERVER['REQUEST_URI'], PHP_URL_PATH );

$is_json_request = strpos( $request_uri, 'wp-json' );

// add filter in json requests only
// this assumes we dont have a post with 'wp-json' in the slug.
if( false !== $is_json_request ){
	add_filter( 'option_active_plugins', 'prefix_offload_plugins' );
}

function prefix_offload_plugins( $plugins ) {

	// You can use this to offload by route.
	global $request_uri;
	$unnecessary_plugins   = [];//or array() if on old php.
	$unnecessary_plugins[] = 'yourplugin/yourplugin_slug.php';

	foreach ( $unnecessary_plugins as $plugin ) {
		$key = array_search( $plugin, $plugins );
		if( false !== $key ){
			unset( $plugins[$key] );
		}
	}
	return $plugins;

}

A quick heads-up for anyone reading this: strpos() returns the position of the substring when found (0, 1, etc) or FALSE if not found.

This doesn't get executed:

if( true === $is_json_request ){
	add_filter( 'option_active_plugins', 'prefix_offload_plugins' );
}

This works:

if( false !== $is_json_request ){
	add_filter( 'option_active_plugins', 'prefix_offload_plugins' );
}

@cabrerahector I updated it, sorry I did it super quick as an example.

No need to apologize. You already are doing enough by sharing this with others. I just pointed out a minor bug in your code :)