drugs.md

Drug Groups

Vitamin D - Several individual compounds is_a vitamin D Often referred to as a single compound, even by DPD/FDA

Prodrug

Loxoprofen -> (2S)-2-(4-{[(1R,2S)-2-hydroxycyclopentyl]methyl}phenyl)propanoic acid (not in drugbank) Loxoprofen provided as a salt (Loxoprofen sodium)

Tegafur -> Fluorouracil (in drugbank)

Combo drugs

Synthetic Conjugated Estrogens, A

• blend of nine synthetic estrogenic substances, some already drugs

Procaine benzylpenicillin

• 2 distinct structures in 1 pill (both approved drugs)

Vayarin

• contains phosphatidylserine-omega 3 and EPA (Eicosapentaenoic acid) enriched.
• both "substances"

Salts

Sildenafil

• sildenafil citrate

Iron

• ferrous glycine sulfate
• ferrous ascorbate
• Iron(II) sulfate (ferrous sulfate)

Esters

Aripiprazole lauroxil

• covalently bound ester formulation (one structure)

Tenofovir Disoproxil Fumarate

• covalently bound ester (Tenofovir Disoproxil) plus a salt (fumarate)

Clathrates

A type of inclusion compound in which small molecules are trapped in the cagelike lattice of macromolecules.

• Warfarin Sodium Clathrate

Radiopharmaceuticals

Fludeoxyglucose (18F)

Technetium (99mTc) sestamibi - Coordination complex

Biotech formulations

Diagnostics: Indium (111In) altumomab pentetate - Indium (111In) altumomab pentetate - mouse monoclonal antibody linked to pentetate which acts as a chelating agent for the radioisotope indium-111.

Botox

• Type A and type B (and others) - different exotoxins produced by the same organism (Clostridium botulinum) - similar properties but distinct

Anti-thymocyte globulin

• could be from horse or rabbit

Calcitonin

• Originally extracted from salmon, now produced either recombinantly or by peptide synthesis, the pharmacological properties of the synthetic and recombinant peptides have been demonstrated to be qualitatively and quantitatively equivalent.
• Salmon calcitonin also different from human calcitonin

Insulin

• Pork, beef, etc. origin
• Combined with zinc
• Insulin analogues
  • recombinant forms of human insulin
  • long, intermediate, and short acting forms
• Combination insulin products
  • e.g. Novolog Mix 70/30
• inhaled products

Others

polistirex (edible plastic - sort of more of a drug delivery) - no structures

• Codeine polistirex

drugs such as oils and foods - no structures

Cholecystokinin - sold as a formulation without any specific compounds

• now there is Sincalide which is_a Cholecystokinin
• both are available as drugs