A simple jQuery script that will create a popup bubble that fixes the issue of disappearing when the mouse hovers over the bubble. Tested with jQuery 1.2.3 and 1.4.2

popup-bubble.css

.popupBubble{
	position:relative;
	display:inline;
}
.popupBubble .popup{
	position:absolute;
	display:none;
	border:1px solid #AAA;
	background:#FFF;
	padding:5px;
	width:300px;
}

popup-bubble.htm

<div class="popupBubble" rel="top-85">
	<img src="/assets/system-images/icons/comment_10.png" class="trigger" />
	<div class="popup">
		<p>Wildcards are acceptable when searching for products:</p>
		<ul>
			<li><strong>% - Any set of characters.</strong>  (e.g. Product SKU's 123SKU, 234SKU, and 345SKU can call be found with %SKU)</li>
		</ul>
	</div>
</div>

popup-bubble.js

$(function(){
	$('.popupBubble').each(function(){
		// Options
		var distance = 10;
		var time = 100;
		var hideDelay = 500;
		
		var hideDelayTimer = null;
		
		// Tracker
		var beingShown = false;
		var shown = false;
		
		var trigger = $('.trigger', this);
		var popup = $('.popup', this).css('opacity',0);
		
		// Each popupBubble div contains a class that specifies the top distance for that element
		var top = $(this).attr('rel').replace('top-','');
		top = '-' + top;
		
		// Set the mouseover and mouseout on both element
		$([trigger.get(0), popup.get(0)]).mouseover(function(){
			// Stops the hide event if we move from the trigger to the popup element
			if(hideDelayTimer) clearTimeout(hideDelayTimer);
			
			// don't trigger the animation again if we're being shown, or already visible
			if(beingShown || shown) return;
			else{
				beingShown = true;
				console.log(top);
				// reset position of popup box
				popup.css({
					top:parseInt(top),
					left:-20,
					display:'block' // brings the popup back into view
				})				
				// (We're using chaining on the popup) now animate it's opacity and position
				.animate({
					top: '-=' + distance + 'px',
					opacity:1
				},time,'swing',function(){
					// once the animation is complete, set the tracker variables
					beingShown = false;
					shown = true;
				});
			}
		}).mouseout(function(){
			// reset the timer if we get fired again - avoids double animations
			if(hideDelayTimer)clearTimeout(hideDelayTimer);
			// Store the timer so that it can be cleared in the mouseover if required
			hideDelayTimer = setTimeout(function(){
				hideDelayTimer = null;
				popup.animate({
					top: '-=' + distance + 'px',
					opacity: 0
				}, time, 'swing', function(){
					// once the animate is complete, set the tracker variables
					shown = false;
					// hide the popup entirelet after the effect (opacity alone doesn't do the job)
					popup.css('display','none');
				});
			}, hideDelay);
		});
		
	});
});