basic cython compile everything

setup.py

# to test:
#   pip install Cython
#   run with CYTHON_BUILD=true setup.py bdist_wheel

def ext_modules():
    from setuptools import Extension
    from setuptools.extension import _have_cython

    cython_build = os.environ.get('CYTHON_BUILD')
    if not _have_cython() or not cython_build:
        return []

    def _pystar_from_name(name):
        return os.path.join(*name.split('.') + ['*.py'])

    def _extension(name):
        return Extension('{}.*'.format(name), [_pystar_from_name(name)])

    from Cython.Build import cythonize
    packages = find_packages(exclude=['ez_setup'])
    return cythonize([_extension(name) for name in packages])
  
  
  setup(ext_modules=ext_modules())

cython file.py
gcc -pthread -fPIC -I/usr/lib/python-exec/python2.7/../../../include/python2.7 -c file.c -o file.o
gcc -pthread -shared -Wl,-O1 -Wl,--as-needed -L. file.o -L/usr/lib64 -lpython2.7 -o file.so

or
cythonize -i file.py

Need zope.interface>=4.0.0, due to Cython being „meant to be "translate once, build anywhere"”: cython/cython#1936 (comment) and https://www.python.org/dev/peps/pep-3155/