Cheng Lou, a former member of the React team, gave an incredible talk at React Europe 2016 entitled "On the Spectrum of Abstraction". That talk is available for viewing here: https://www.youtube.com/watch?v=mVVNJKv9esE
It's only a half-hour, but it is mind-blowing. It's worth re-watching two or three times, to let the ideas sink in.
I just rewatched the talk for some research, and wrote down a summary that's semi-transcript-ish. I didn't see any other transcripts for this talk, other than the auto-generated closed captions, so I wanted to share for reference.