What are the benefits of one of these over the other?

stuff.js

// Is there a benefit to one of these
Foobar.prototype = {};
Foobar.prototype.constructor = Foobar;
function Foobar() {};
Foobar.prototype.baz = function(){};

// over the other?
function Foobar() {};
var prototype = (Foobar.prototype = {}); //Base is an object that can be {}
prototype.constructor = Foobar;
prototype.baz = function(){};