Python-bitcointx is a Python3 (3.6+) library to work with Bitcoin transactions, and other related things, like addresses, keys, Bitcoin script, etc.
It is based on popular python-bitcoinlib library, but with slightly different focus. Some functionality was removed to reduce the maintenance burden, while other useful functionaliy was added (full list of changes is in release notes).
This library should be viewed as a completely separate library from python-bitcoinlib, it diverges from python-bitcoinlib significantly and breaks the compatibility when it makes sense. Still, it can accomodate most of the code written for python-bitcoinlib, with minor adjustments.
I did not release the official announcement of the library until now, so here it goes.