Unity reset layout by hotkey (default Ctrl + Shift + R). Put script to any Editor folder.

LayoutHotKey.cs

using System;
using System.IO;
using System.Reflection;
using UnityEditor;

public static class LayoutHotKey
{
    const string layoutName = "Temp/autosave.wlt";

    //  % (ctrl), # (shift), & (alt)
    //to change check docs https://docs.unity3d.com/ScriptReference/MenuItem.html
    [MenuItem("Window/Layouts/Reset Layout %#r")]
    static void ResetLayout()
    {
        Save();
        Load();
    }

    static void Save() {
        LayoutUtility.SaveLayout(layoutName);
    }
    
    static void Load() {
        LayoutUtility.LoadLayout(layoutName);
    }
    

 
}


public static class LayoutUtility {
 
    private enum MethodType {Save, Load};
 
    static MethodInfo GetMethod (MethodType method_type) {
 
        Type layout = Type.GetType("UnityEditor.WindowLayout,UnityEditor");
 
        MethodInfo save = null;
        MethodInfo load = null;
 
        if (layout != null) {
            load = layout.GetMethod("LoadWindowLayout", BindingFlags.NonPublic | BindingFlags.Public | BindingFlags.Static, null, new Type[] {typeof(string), typeof(bool)}, null);
            save = layout.GetMethod("SaveWindowLayout", BindingFlags.NonPublic | BindingFlags.Public | BindingFlags.Static, null, new Type[] {typeof(string)}, null);
        }
 
        if (method_type == MethodType.Save) {
            return save;
        }
        else {
            return load;
        }
 
    }
 
    public static void SaveLayout(string path) {
        path = Path.Combine(Directory.GetCurrentDirectory(), path);
        GetMethod(MethodType.Save).Invoke(null, new object[] {path});
    }
 
    public static void LoadLayout(string path) {
        path = Path.Combine(Directory.GetCurrentDirectory(), path);
        GetMethod(MethodType.Load).Invoke(null, new object[] { path, false });
    }
 
}