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Created November 20, 2012 16:38
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dump of #search->document
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What Is <Node id="9" />Leukemia<Node id="17" />?
<Node id="20" />Leukemia<Node id="28" /> is an abnormal rise in the number of white <Node id="72" />blood <Node id="78" />cells<Node id="83" />. The white <Node id="95" />blood <Node id="101" />cells<Node id="106" /> crowd out other <Node id="123" />blood <Node id="129" />cell<Node id="133" /> <Node id="134" />elements<Node id="142" /> such as red <Node id="155" />blood <Node id="161" />cells<Node id="166" /> and platelets. The elevated white <Node id="201" />blood <Node id="207" />cells<Node id="212" /> are immature and do not <Node id="237" />function<Node id="245" /> properly.
<Node id="257" />Leukemia<Node id="265" /> -- the term derives from the Greek words for 'white' and '<Node id="324" />blood<Node id="329" />' -- is often considered a disease of <Node id="367" />children<Node id="375" />, yet <Node id="381" />it<Node id="383" /> actually <Node id="393" />affects<Node id="400" /> far more <Node id="410" />adults<Node id="416" />. <Node id="418" />It<Node id="420" /> is more common in <Node id="439" />men<Node id="442" /> than <Node id="448" />women<Node id="453" /> and in Caucasians than African-Americans. There <Node id="502" />will<Node id="506" /> be 47,150 new <Node id="521" />patients<Node id="529" /> diagnosed with all forms of <Node id="558" />leukemia<Node id="566" /> in the <Node id="574" />United States<Node id="587" /> in 2012 with 23,540 <Node id="608" />deaths<Node id="614" /> due to <Node id="622" />leukemia<Node id="630" /> in 2012.
Recommended Related to <Node id="664" />Leukemia<Node id="672" />
To <Node id="676" />Learn<Node id="681" /> More About Chronic Lymphocytic <Node id="713" />Leukemia<Node id="721" />
For more <Node id="731" />information<Node id="742" /> from the <Node id="752" />National<Node id="760" /> <Node id="761" />Cancer<Node id="767" /> Institute about chronic lymphocytic <Node id="804" />leukemia<Node id="812" />, see the following: <Node id="833" />Leukemia<Node id="841" /> <Node id="842" />Home Page<Node id="851" /> What You Need to Know About™ <Node id="881" />Leukemia<Node id="889" /> <Node id="890" />Drugs<Node id="895" /> Approved for Chronic Lymphocytic <Node id="929" />Leukemia<Node id="937" /> Targeted <Node id="947" />Cancer<Node id="953" /> Therapies Understanding <Node id="978" />Cancer<Node id="984" /> Series: Targeted Therapies <Node id="1012" />Biological Therapies<Node id="1032" /> for <Node id="1037" />Cancer<Node id="1043" />: Questions and Answers For general <Node id="1079" />cancer<Node id="1085" /> <Node id="1086" />information<Node id="1097" /> and other <Node id="1108" />resources<Node id="1117" /> from the <Node id="1127" />National<Node id="1135" /> <Node id="1136" />Cancer<Node id="1142" /> Institute, see the following: What You Need to K...
<Node id="1195" />Read<Node id="1199" /> the To <Node id="1207" />Learn<Node id="1212" /> More About Chronic Lymphocytic <Node id="1244" />Leukemia<Node id="1252" /> article > >
<Node id="1265" />Blood<Node id="1270" /> has three types of <Node id="1290" />cells<Node id="1295" />: white <Node id="1303" />blood <Node id="1309" />cells<Node id="1314" /> that fight <Node id="1326" />infection<Node id="1335" />, red <Node id="1341" />blood <Node id="1347" />cells<Node id="1352" /> that carry <Node id="1364" />oxygen<Node id="1370" />, and platelets that help <Node id="1396" />blood<Node id="1401" /> to clot, all suspended in its liquid <Node id="1439" />plasma<Node id="1445" />. Every day, hundreds of billions of new <Node id="1486" />blood <Node id="1492" />cells<Node id="1497" /> are produced in the <Node id="1518" />bone <Node id="1523" />marrow<Node id="1529" /> -- most of them red <Node id="1550" />cells<Node id="1555" />. In <Node id="1560" />people<Node id="1566" /> with <Node id="1572" />leukemia<Node id="1580" />, however, the body starts producing more white <Node id="1628" />cells<Node id="1633" /> than <Node id="1639" />it<Node id="1641" /> needs. Many of the extra white <Node id="1673" />cells<Node id="1678" /> do not mature normally, yet they tend to <Node id="1720" />live well<Node id="1729" /> beyond their normal life span.
Despite their vast numbers, these <Node id="1796" />leukemia<Node id="1804" /> <Node id="1805" />cells<Node id="1810" /> are unable to fight <Node id="1831" />infection<Node id="1840" /> the way normal white <Node id="1862" />blood <Node id="1868" />cells<Node id="1873" /> do. As they accumulate, they interfere with vital organ <Node id="1930" />functions<Node id="1939" />, including the <Node id="1955" />production<Node id="1965" /> of healthy <Node id="1977" />blood <Node id="1983" />cells<Node id="1988" />. Eventually, the body does not have enough red <Node id="2036" />blood <Node id="2042" />cells<Node id="2047" /> to supply <Node id="2058" />oxygen<Node id="2064" />, enough platelets to ensure proper clotting, or enough normal white <Node id="2133" />blood <Node id="2139" />cells<Node id="2144" /> to fight <Node id="2154" />infection<Node id="2163" />. This <Node id="2170" />results<Node id="2177" /> in persons with <Node id="2194" />leukemia<Node id="2202" /> being anemic as well as increasing their <Node id="2244" />risks<Node id="2249" /> of �bruising, <Node id="2264" />bleeding<Node id="2272" />, and <Node id="2278" />infection<Node id="2287" />.
Cases of <Node id="2299" />leukemia<Node id="2307" /> are classified as acute or chronic. The <Node id="2348" />cells<Node id="2353" /> in acute <Node id="2363" />leukemia<Node id="2371" /> start multiplying before they develop beyond their immature stage. Chronic <Node id="2447" />leukemia<Node id="2455" /> progress more slowly, with the <Node id="2487" />leukemia<Node id="2495" /> <Node id="2496" />cells<Node id="2501" /> developing to full maturity. <Node id="2531" />Leukemia<Node id="2539" /> is further classified according to the type of white <Node id="2593" />blood <Node id="2599" />cell<Node id="2603" /> involved, most commonly myeloid or lymphoid. Under a microscope, the two main types of white <Node id="2697" />blood <Node id="2703" />cells<Node id="2708" /> are easily distinguishable as myeloid <Node id="2747" />cells<Node id="2752" /> contain tiny particles or granules; lymphoid <Node id="2798" />cells<Node id="2803" /> usually do not.
�
What <Node id="2829" />Causes<Node id="2835" /> <Node id="2836" />Leukemia<Node id="2844" />?
No one knows exactly what <Node id="2873" />causes<Node id="2879" /> <Node id="2880" />leukemia<Node id="2888" />.�However, <Node id="2899" />chromosome <Node id="2910" />abnormalities<Node id="2923" /> are associated with <Node id="2944" />leukemia<Node id="2952" />. But they do not <Node id="2970" />cause<Node id="2975" /> the <Node id="2980" />leukemia<Node id="2988" />. For <Node id="2994" />example<Node id="3001" />,virtually all�<Node id="3016" />people<Node id="3022" /> with CML and some with ALL have an abnormal <Node id="3067" />chromosome<Node id="3077" /> known as the Philadelphia <Node id="3104" />Chromosome<Node id="3114" /> in their white <Node id="3130" />blood <Node id="3136" />cells<Node id="3141" /> and <Node id="3146" />bone <Node id="3151" />marrow<Node id="3157" />. As with other <Node id="3173" />leukemia<Node id="3181" /> types, the <Node id="3193" />chromosome <Node id="3204" />abnormality<Node id="3215" /> is an acquired <Node id="3231" />abnormality<Node id="3242" />; <Node id="3244" />it<Node id="3246" /> is neither inherited nor passed on to one's <Node id="3291" />children<Node id="3299" />.
Genetic �<Node id="3311" />disorders<Node id="3320" /> associated with acute myeloid <Node id="3351" />leukemia<Node id="3359" /> include �<Node id="3369" />Down <Node id="3374" />syndrome<Node id="3382" /> , Bloom <Node id="3391" />syndrome<Node id="3399" />, Fanconi <Node id="3409" />anemia<Node id="3415" />, or immune deficiency <Node id="3438" />disorders<Node id="3447" /> such as Wiskott-Aldrich� <Node id="3473" />syndrome<Node id="3481" /> and <Node id="3486" />ataxia<Node id="3492" />-telangectasia. In addition, at least one <Node id="3534" />virus<Node id="3539" /> in the same <Node id="3552" />family<Node id="3558" /> as the <Node id="3566" />human immunodeficiency <Node id="3589" />virus<Node id="3594" /> (<Node id="3596" />HIV<Node id="3599" />) has been associated with a rare form of the disease. This is the HTLV-1 <Node id="3673" />virus<Node id="3678" />.
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</GateDocument>
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