index.js

class Game {
  constructor(grid, snake) {
    this.grid = grid;
    this.snake = snake;
  }
  
  async run() {
    while (true) {
      this.grid.render();

      const updates = this.snake.update();
      updates.forEach(x => {
        this.grid.setPoint(x.point, x.state);
      });

      await this.sleep(delay);
    }
  }
  
  sleep(ms) {
    return new Promise(resolve => setTimeout(resolve, ms));
  }
}

... 

const delay = 50;

const grid = new Grid(width, height, blockarea, margin, ctx);
const snake = new Snake({x:10, y:10});
const game = new Game(grid, snake, delay);