gistfile1.el

(when (load "flymake" t)
  (load "flymake-cursor" t)
  (defun flymake-pyflakes-init ()
    (let* ((temp-file (flymake-init-create-temp-buffer-copy
                       'flymake-create-temp-inplace))
           (local-file (file-relative-name
                        temp-file
                        (file-name-directory buffer-file-name))))
      (list "/PATH/TO/YOUR/pyflakes" (list local-file))))

  (add-to-list 'flymake-allowed-file-name-masks
               '("\\.py\\'" flymake-pyflakes-init))

  (add-hook 'python-mode-hook 'flymake-mode)

  (mapc (lambda (x)
          (when (equal (car x) "\\.html?\\'")
            (delete x flymake-allowed-file-name-masks)))
        flymake-allowed-file-name-masks))

(add-hook 'find-file-hook 'flymake-find-file-hook)