Try ClojureScript Graal.js

cljs-graaljs.md

First, you need to install GraalVM and set things up so that the java installed with GraalVM is picked up in your path. See http://www.graalvm.org for more details.

With that in place, you can manage the Truffle languages installed.

Here you can see that I've already installed Python and Ruby:

$ gu list
ComponentId              Version             Component name
----------------------------------------------------------------
python                   1.0.0-rc3           Graal.Python
ruby                     1.0.0-rc3           TruffleRuby

Let's add R to the mix

$ gu install R
Downloading: Component catalog
Processing component archive: Component R
Downloading: Component R
Installing new component: FastR (org.graalvm.R, version 1.0.0-rc3)
...

Let's set up to use the latest SHA in my fork of ClojureScript that adds Graal.js support by creating a deps.edn file with

{:deps {org.clojure/clojurescript {:git/url "https://github.com/mfikes/clojurescript"
                                   :sha "51e0e3f355ad922607ba7013b402979338794634"}}}

Now let's start up a ClojureScript REPL, specifying graaljs as our REPL environment (instead, of say node, browser, or nashorn), and calculate the sum from 1 to 100 using ClojureScript, R, Ruby, Python, and JavaScript:

$ clj --main cljs.main --repl-env graaljs --repl
Checking out: https://github.com/mfikes/clojurescript at 51e0e3f355ad922607ba7013b402979338794634
cljs.user=> (reduce + (range 1 101))
5050
cljs.user=> (.eval js/Polyglot "R" "sum(1:100)")
5050
cljs.user=> (.eval js/Polyglot "ruby" "(1..100).reduce(:+)")
5050
cljs.user=> (.eval js/Polyglot "python" "sum(x for x in range(1, 101))")
Error: Operation is not allowed for: /private/tmp/graaljs
cljs.user=> (.eval js/Polyglot "python" "sum(x for x in range(1, 101))")
5050
cljs.user=> (.eval js/Polyglot "js" "(100 * (100 + 1)) / 2")
5050

For some reason, Python fails on first use, but works subsequent times. ¯\(ツ)/¯