Proof of concept! Transforms Shopify GraphQL API responses to remove the need to type "edges" and "node", while also adding support for Ruby dot notation. We could also transform createAt to created_at.. but I think that will be "too much magic", as it won't match docs etc.

graphql_response_rubyfier.rb

require 'json'

class GraphqlResponseRubyfier
  def initialize(response)
    @response = JSON.parse(response)
  end

  def rubyfy
    rubyfied_response = to_o(@response)
    puts(rubyfied_response)
    puts(rubyfied_response.data.product.collections.collect(&:handle))
    rubyfied_response
  end

  def to_o(obj)
    if obj.is_a?(Hash) && obj['edges']
      to_o(obj['edges'])
    elsif obj.is_a?(Hash)
      OpenStruct.new(obj.map { |key, val| [key, to_o(val)] }.to_h)
    elsif obj.is_a?(Array)
      obj.map { |o| o['node'] ? to_o(o['node']) : to_o(o) }
    else
      obj
    end
  end
end

EXAMPLE_RESPONSE = "{\r\n    \"data\": {\r\n      \"product\": {\r\n        \"availablePublicationCount\": 3,\r\n        \"collections\": {\r\n          \"edges\": [\r\n            {\r\n              \"node\": {\r\n                \"handle\": \"great-gifts\"\r\n              }\r\n            }\r\n          ]\r\n        },\r\n        \"createdAt\": \"2017-09-18T14:05:28Z\",\r\n        \"defaultCursor\": \"eyJsaW1pdCI6MSwib3JkZXIiOiJpZCBhc2MiLCJsYXN0X2lkIjoxMDUyMTU3ODYyNiwibGFzdF92YWx1ZSI6MTA1MjE1Nzg2MjYsImRpcmVjdGlvbiI6Im5leHQifQ==\",\r\n        \"description\": \"This t-shirt comes in a range of colors. It's made with super-soft combed cotton and a slim fit. Cotton-blend thread in the seams guarantees an even dye.\",\r\n        \"descriptionHtml\": \"<meta charset=\\\"utf-8\\\"><span>This t-shirt comes in a range of colors.  It's made with super-soft combed cotton and a slim fit.  Cotton-blend thread in the seams guarantees an even dye.<\/span>\",\r\n        \"featuredImage\": {\r\n          \"id\": \"gid:\/\/shopify\/ProductImage\/23213976514\"\r\n        },\r\n        \"feedback\": {\r\n          \"details\": []\r\n        },\r\n        \"giftCardTemplateSuffix\": null,\r\n        \"handle\": \"classic-crew-neck\",\r\n        \"hasOnlyDefaultVariant\": false,\r\n        \"hasOutOfStockVariants\": false,\r\n        \"id\": \"gid:\/\/shopify\/Product\/10521578626\",\r\n        \"images\": {\r\n          \"edges\": [\r\n            {\r\n              \"node\": {\r\n                \"id\": \"gid:\/\/shopify\/ProductImage\/23213976514\"\r\n              }\r\n            },\r\n            {\r\n              \"node\": {\r\n                \"id\": \"gid:\/\/shopify\/ProductImage\/23213976578\"\r\n              }\r\n            },\r\n            {\r\n              \"node\": {\r\n                \"id\": \"gid:\/\/shopify\/ProductImage\/23213976642\"\r\n              }\r\n            }\r\n          ]\r\n        },\r\n        \"inCollection\": false,\r\n        \"isGiftCard\": false,\r\n        \"legacyResourceId\": \"10521578626\",\r\n        \"metafield\": null,\r\n        \"metafields\": {\r\n          \"edges\": []\r\n        },\r\n        \"onlineStorePreviewUrl\": \"https:\/\/test-shop.myshopify.com\/products\/classic-crew-neck\",\r\n        \"onlineStoreUrl\": \"https:\/\/test-shop.myshopify.com\/products\/classic-crew-neck\",\r\n        \"options\": [\r\n          {\r\n            \"name\": \"Size\"\r\n          },\r\n          {\r\n            \"name\": \"Color\"\r\n          }\r\n        ],\r\n        \"priceRange\": {\r\n          \"maxVariantPrice\": {\r\n            \"amount\": \"4200.0\"\r\n          },\r\n          \"minVariantPrice\": {\r\n            \"amount\": \"4200.0\"\r\n          }\r\n        },\r\n        \"productType\": \"\",\r\n        \"publicationCount\": 4,\r\n        \"publishedAt\": \"2017-09-18T14:05:17Z\",\r\n        \"resourcePublications\": {\r\n          \"edges\": [\r\n            {\r\n              \"node\": {\r\n                \"isPublished\": true\r\n              }\r\n            },\r\n            {\r\n              \"node\": {\r\n                \"isPublished\": true\r\n              }\r\n            },\r\n            {\r\n              \"node\": {\r\n                \"isPublished\": true\r\n              }\r\n            }\r\n          ]\r\n        },\r\n        \"seo\": {\r\n          \"title\": null\r\n        },\r\n        \"storefrontId\": \"Z2lkOi8vc2hvcGlmeS9Qcm9kdWN0LzEwNTIxNTc4NjI2\",\r\n        \"tags\": [],\r\n        \"templateSuffix\": null,\r\n        \"title\": \"Classic crew neck\",\r\n        \"totalInventory\": 12,\r\n        \"totalVariants\": 6,\r\n        \"tracksInventory\": true,\r\n        \"unpublishedPublications\": {\r\n          \"edges\": [\r\n            {\r\n              \"node\": {\r\n                \"name\": \"Google Shopping\"\r\n              }\r\n            }\r\n          ]\r\n        },\r\n        \"updatedAt\": \"2019-01-23T01:35:15Z\",\r\n        \"variants\": {\r\n          \"edges\": [\r\n            {\r\n              \"node\": {\r\n                \"displayName\": \"Classic crew neck - Small \/ Blue\"\r\n              }\r\n            },\r\n            {\r\n              \"node\": {\r\n                \"displayName\": \"Classic crew neck - Small \/ Green\"\r\n              }\r\n            },\r\n            {\r\n              \"node\": {\r\n                \"displayName\": \"Classic crew neck - Medium \/ Blue\"\r\n              }\r\n            }\r\n          ]\r\n        },\r\n        \"vendor\": \"John's Apparel\"\r\n      }\r\n    }\r\n  }".freeze

GraphqlResponseRubyfier.new(EXAMPLE_RESPONSE).rubyfy

# Useage: ruby graphql_response_rubyfier.rb

# Outputs:
# <OpenStruct data=#<OpenStruct product=#<OpenStruct availablePublicationCount=3, collections=[#<OpenStruct handle="great-gifts">], createdAt="2017-09-18T14:05:28Z", defaultCursor="eyJsaW1pdCI6MSwib3JkZXIiOiJpZCBhc2MiLCJsYXN0X2lkIjoxMDUyMTU3ODYyNiwibGFzdF92YWx1ZSI6MTA1MjE1Nzg2MjYsImRpcmVjdGlvbiI6Im5leHQifQ==", description="This t-shirt comes in a range of colors. It's made with super-soft combed cotton and a slim fit. Cotton-blend thread in the seams guarantees an even dye.", descriptionHtml="<meta charset=\"utf-8\"><span>This t-shirt comes in a range of colors.  It's made with super-soft combed cotton and a slim fit.  Cotton-blend thread in the seams guarantees an even dye.</span>", featuredImage=#<OpenStruct id="gid://shopify/ProductImage/23213976514">, feedback=#<OpenStruct details=[]>, giftCardTemplateSuffix=nil, handle="classic-crew-neck", hasOnlyDefaultVariant=false, hasOutOfStockVariants=false, id="gid://shopify/Product/10521578626", images=[#<OpenStruct id="gid://shopify/ProductImage/23213976514">, #<OpenStruct id="gid://shopify/ProductImage/23213976578">, #<OpenStruct id="gid://shopify/ProductImage/23213976642">], inCollection=false, isGiftCard=false, legacyResourceId="10521578626", metafield=nil, metafields=[], onlineStorePreviewUrl="https://test-shop.myshopify.com/products/classic-crew-neck", onlineStoreUrl="https://test-shop.myshopify.com/products/classic-crew-neck", options=[nil, nil], priceRange=#<OpenStruct maxVariantPrice=#<OpenStruct amount="4200.0">, minVariantPrice=#<OpenStruct amount="4200.0">>, productType="", publicationCount=4, publishedAt="2017-09-18T14:05:17Z", resourcePublications=[#<OpenStruct isPublished=true>, #<OpenStruct isPublished=true>, #<OpenStruct isPublished=true>], seo=#<OpenStruct title=nil>, storefrontId="Z2lkOi8vc2hvcGlmeS9Qcm9kdWN0LzEwNTIxNTc4NjI2", tags=[], templateSuffix=nil, title="Classic crew neck", totalInventory=12, totalVariants=6, tracksInventory=true, unpublishedPublications=[#<OpenStruct name="Google Shopping">], updatedAt="2019-01-23T01:35:15Z", variants=[#<OpenStruct displayName="Classic crew neck - Small / Blue">, #<OpenStruct displayName="Classic crew neck - Small / Green">, #<OpenStruct displayName="Classic crew neck - Medium / Blue">], vendor="John's Apparel">>>
# "great-gifts"

Thanks to this StackOverflow answer for the inspiration: https://stackoverflow.com/a/57262111/1619602