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This works via use of medium and weak stimulants that increase neurotransmitters via the TAAR1 intracellular protein binding to reverse flow of neurotransmitters to the outside of neuron into synaptic cleft. AND, via use of MAO inhibitors to increase the time neurotransmitters spend in the synaptic cleft. AND, lastly the correct cofactors to support neuroplasticity, prevent neuron cell death, and neurotransmitter production.
The two items that decrease blood pressure are: L-theanine ashwagandha
AND THUS, they cannot be taken with blood pressure medicine or if you are a women of child bearing age and in both those cases should be avoided.
I AM NOT A MEDICAL DOCTOR AND you should ask a doctor to match this list up against your medicine list to see if any medicines conflict with it before taking!
My Nootrpoics Stack:
Bakers Cacoa -caffeine, targets TAAR1 in DA and NE neurons as weak binder also targets the dopamine hereto dimers and co-competes with the sleep molecule adenosine to keep the dopamine receptor open -adandamide(AEA N-arac hidonoylethanolamine), targets CBD1 on astrocytes is a bliss mood molecule (and yes its the same receptor that THC targets with no ill side effects)
*its the unsweetend kind that tastes bitter. 4 squares taken with breakfast cobined with Green Tea ECGC lasts 12-16 hours as far as attention and focus.
Force Factor Modern Mushrooms -Lions Mane targets enzymes that produce nerge grwoth factor NGF. -Maitake blocks AMPA receptor expression reducing depression -Chaga raises acetycholine levels by inhibiting acetylcholinesterase and that improves memory and learning -cordyceps increse release of neurotransmitter catecholamines which are dopamine, norepinephrine and epinephrine.
Omega-3(DGA) Omega-6(EHA) -Omega-3 increases BDNF brain derived nerve gwoth factor -Omega 6 also increases BDNF
Acetylcarnitine and Alpha Lipoic Acid(ALCAR + ALA) -ALCAR increases energy by increasing fatty acid transport to mitochondria of neurons -ALA ncreases acetylcholine production by activation of choline acetyltransferase and increases glucose uptake. This process supplies more Acetyl-CoA for the production of acetylcholine.
Force Factor Amazing ASHWA **Cautioon, ashwagandha lowers blood pressure and cannot be taken with blood pressure medicine or if you are a women of child bearing age. So you will need to replace it with something else and buy the other individual ingredients of ForceFactor Amazing ASHWA. L-theanine also lowers blood pressure and thus needs to be subsituted.
-Ashwagandha extract inhibits acetylcholinesterase. The enzyme is responsible for breaking down the key neurotransmitter acetylcholine. Boosting memory, learning, and cognition.enhances GABA receptors and regulates serotonin in the brain. It appears to work on neuron receptors, enabling GABA to connect more easily. This inhibits the signals present under a stress response in the brain. Anxiety is reduced. Reduces blood pressure.
-Ginseng is a serotonin and norepinephrine reuptake inhibitor, which is different tnan a MAOI which has to enter via those reuptake proteins to block MAO but the effect is simular in that NE and SE are kept in the synaptic cleft. Also boosts NGF.
-Goji Berry improves neuron plasticity, in other words new neuron growth.
-Bacopa Monnieri Bacopa’s two active components are bacosides A and B. They improve the signaling of electrical impulses between neurons in your brain. Bacosides also help rebuild damaged neurons. It also reduces heat shock protein expression which increase during stress.
-Green Tea extremely weak binder to TAAR1 via ECGC which forces the transporter protein in dopamine and ne neurons to rerverse transport neuron transmitters outside of neurons to reach the synaptic cleft.
-Black Maca contains building blocks of neurotransmitters, namely most of the amino acids. It also boost anandamide the bliss molecule that binds to CBD1 on the astrocytes. It also inhibits FAAH thus blocking breakdown of anandamide.
-L-Theanine -lowers blood pressure -as analog for L-glutamate and L-glutamine will increase GABA, serotonin and dopamine -increases alpha and theta brain wabes -agonist of NMDA receptors which inhibis glutamate release and protects from overstimulation.
-Rhodiola is a MAO inhibitor and through that action increases serotonin and norepinephrine. Rhodiola directly modulates HPA axis activity by helping restore the cortisol feedback loop. Rhodiola upregulates NPY, a peptide involved in stress resilience and cognitive performance under pressure
-BioPerine Piperine inhibits the drug transporter P-glycoprotein, and the drug-metabolizing enzyme CYP3A4 in your liver. Allowing more of each nootropic in your stack to be absorbed and used as intended. Piperine is a powerful monoamine oxidase (MAO) inhibitor (MAOI). Boosting serotonin, dopamine and norepinephrine levels in the brain. Decreasing anxiety, improving mood and memory
-Vitamin D is the cofactor to production of GABA, Glutamate, Glutamine. Serotonin and Dopamine. As a hormone in the brain it regulates 2000 genes and participates in NGF production.
-Niacin(B3) precursor to NAD and NADPH which are involved in ATP production. Also boosts NO production which improves blood flow.
-Vitamin B6 cofactor to production of dopamine, epinephrine, GABA, serotonin, and norepinephrine. helps regulates homocysteine to reduce brain inflamation.
-Vitamin B12 Vitamin B12 is needed to regulate homocysteine. High homocysteine levels are linked to inflammation that can lead to blood vessel damage. Vitamin B12 is a cofactor in the synthesis of neurotransmitters dopamine, GABA, norepinephrine, and serotonin
-Calcium In your brain, calcium regulates neurotransmitter synthesis and release, neuronal excitability, and is involved in long-term potentiation for long-term memory formation
-Phosphorous Precursor to ATP for neuron energy Precursor to Phospholipids which form cell structures of neurons Assists in neuroplasticity in forming new neuron connections
-Zinc -Zinc is integral to the synthesis of proteins, the regulation of signaling cascades, gene transcription and neurotransmitter transport. It’s involved in DNA repair and synthesis and methylation. -Zinc inhibits NMDA receptors which reduces glutamate toxicity. And zinc modulates the activity of proteins such as receptors and enzymes that are involved in the regulation of macromolecules, the regulation of signaling cascades and gene transcription, and transport processes. -Low zinc levels are found in depression, and the lower the level the more severe the depression. Zinc increases serotonin uptake in select brain regions which increases the efficacy of antidepressants. And it reduces depression because is increases BDNF.
-Selenium precursor to glutathione which protects dopamine neurons from oxidation stress