How to use nootropics to bring combined ADHD under control.

why-adhd-this-way.txt

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I am not a MD or a Psychologist, AND this
is not medical advice.

But, it would seem given recent ADHD studies 
that 5 neurotransmitters are involved rather just
dopamine and norepinephrine by themselves.

AND, overwhelming how DA and NE transporters and
intercellular TAAR1 work without considering rest of the 
complex set of systems seems to unbalance things.

Instead the Nootropic approach uses less strong 
TAAR1 agonists such as Caffeine and ECGC from 
Green Tea. Why? Strong binding to TAAR1 over time
makes an addition molecular switch to be expressed 
in the dopamine neuron leading to addiction.

That weak binding to TAAR1 by caffeine and ECGC
triggers the DA transporter to reverse and transport
dopamine out of the neuron into the synaptic 
cleft beyond what the VMAT2 does.

In other words, I am choosing to weak binding of 
TAAR1 combined with hrbs that act as MAO inhibitors.
MAO is the set of enzymes that break down neurotransmitters
intracellularly in the neuron itself after the neurotransmitter
is uptaken by the transporter proteins on neuron cell surfaces.

The other major aspect is proper support of the 
astrocyte g-cycle involving glutamate, glutamine, and
GABA. As astrocytes control the dopamine signaling 
via that cycle.

The final polish is added via using the correct co-factors 
that aid in neuron plasticity, prevent cell death, etc.

This is a re-use of my molecular biology studies at 
Purdue Univeristy. Yoou still should consult a doctor
to see if this conflicts with any medicines you are taking.

For example, ashwagandha lowers blood pressure so women
of child bearing ages usually have to replace it with 
somethng else.

The other major nuance here is that I when literature and even
me refer to MAO inhibitors increasing DA,  NE, serotonin, etc.;
we in fact mean that the neurotransmitters stay longer
in the synaptic cleft. Its not increasing like the TAAR1 binding
reactions of even caffeine which is a medium stimulant.

In short words, choosing to increase time of neurotransmitters in
the synaptic cleft rather than concentration has less oxidative
stress. And  that by promoting less neuron cell death means the
increase in NGF and BDNF is used for new neurons needed for new
memories instead of replacing neurons destroyed by cell death.

My Nootropics for combined ADHD type:

Bakers Cacoa
   -caffeine, targets TAAR1 in DA and NE neurons as weak binder
    also targets the dopamine hereto dimers and co-competes with 
    the sleep molecule adenosine to keep the dopamine receptor open
   -adandamide(AEA N-arac hidonoylethanolamine), targets CBD1 
    on astrocytes is a bliss mood molecule
    (and yes its the same receptor that THC targets with no ill side effects)

*its the unsweetend kind that tastes bitter. 4 squares taken with
 breakfast cobined with Green Tea ECGC lasts 12-16 hours as far as
 attention and focus.

GABA
  -targets the GABA receptor of astrocytes.
  -helps manage dopamine via inhibitor activities
  -typical doasge is 750mg

L-Glutamine
   -targets the Glutamine receptors of astrocytes
   -assists astrocyte control of dopamine signaling


Force Factor Modern Mushrooms
  -Lions Mane targets enzymes that produce nerge grwoth factor NGF.
  -Maitake blocks AMPA receptor expression reducing depression
  -Chaga raises acetycholine levels by inhibiting acetylcholinesterase and
   that improves memory and learning
  -cordyceps increse release of neurotransmitter catecholamines which 
   are dopamine, norepinephrine and epinephrine.

Omega-3(DGA) Omega-6(EHA)
   -Omega-3 increases BDNF brain derived nerve gwoth factor
   -Omega 6 also increases BDNF
   

Acetylcarnitine and Alpha Lipoic Acid(ALCAR + ALA)
   -ALCAR increases energy by increasing fatty acid transport to mitochondria of 
    neurons
   -ALA ncreases acetylcholine production by activation of choline acetyltransferase 
    and increases glucose uptake. This process supplies more Acetyl-CoA for the production 
    of acetylcholine.


Force Factor Amazing ASHWA
  **Cautioon, ashwagandha lowers blood pressure and cannot be taken with 
    blood pressure medicine or if you are a women of child bearing age.
    So you will need to replace it with something else and buy the 
    other individual ingredients of ForceFactor Amazing ASHWA.
    L-theanine also lowers blood pressure and thus needs to be subsituted.

   -Ashwagandha extract inhibits acetylcholinesterase. The enzyme is responsible 
    for breaking down the key neurotransmitter acetylcholine. Boosting memory, 
    learning, and cognition.enhances GABA receptors and regulates serotonin in the brain. 
    It appears to work on neuron receptors, enabling GABA to connect more easily. 
    This inhibits the signals present under a stress response in the brain. Anxiety is reduced.
    Reduces blood pressure.

   -Ginseng is a serotonin and norepinephrine reuptake inhibitor, which is different tnan a
    MAOI which has to enter via those reuptake proteins to block MAO but the effect is simular
    in that NE and SE are kept in the synaptic cleft. Also boosts NGF.

   -Goji Berry improves neuron plasticity, in other words new neuron growth.

   -Bacopa Monnieri Bacopa’s two active components are bacosides A and B. They improve the 
    signaling of electrical impulses between neurons in your brain. Bacosides also 
    help rebuild damaged neurons. It also reduces heat shock protein expression 
    which increase during stress.

   -Green Tea extremely weak binder to TAAR1 via ECGC which forces the transporter 
    protein in dopamine and ne neurons to rerverse transport neuron transmitters outside
    of neurons to reach the synaptic cleft.
 
   -Black Maca contains building blocks of neurotransmitters, namely most of the amino acids.
    It also boost anandamide the bliss molecule that binds to CBD1 on the astrocytes. It also
    inhibits FAAH thus blocking breakdown of anandamide.

   -L-Theanine
     -lowers blood pressure
     -as analog for L-glutamate and L-glutamine will increase GABA, serotonin and 
      dopamine
     -increases alpha and theta brain wabes
     -agonist of NMDA receptors which inhibis glutamate release and protects 
      from overstimulation.

   -Rhodiola is a MAO inhibitor and through that action increases serotonin and 
    norepinephrine. Rhodiola directly modulates HPA axis activity by helping restore 
    the cortisol feedback loop. Rhodiola upregulates NPY, a peptide involved in stress 
    resilience and cognitive performance under pressure

   -BioPerine Piperine inhibits the drug transporter P-glycoprotein, and the 
    drug-metabolizing enzyme CYP3A4 in your liver. Allowing more of each nootropic 
    in your stack to be absorbed and used as intended. Piperine is a powerful 
    monoamine oxidase (MAO) inhibitor (MAOI). Boosting serotonin, dopamine and 
    norepinephrine levels in the brain. Decreasing anxiety, improving mood and memory

   -Vitamin D is the cofactor to production of GABA, Glutamate, Glutamine. 
    Serotonin and Dopamine. As a hormone in the brain it regulates 2000 genes and 
    participates in NGF production.

   -Niacin(B3)
     precursor to NAD and NADPH which are involved in ATP production. Also boosts 
     NO production which improves blood flow.

   -Vitamin B6
    cofactor to production of dopamine, epinephrine, GABA, serotonin, and norepinephrine.
    helps regulates homocysteine to reduce brain inflamation.

   -Vitamin B12
    Vitamin B12 is needed to regulate homocysteine. High homocysteine levels are linked 
    to inflammation that can lead to blood vessel damage. Vitamin B12 is a cofactor 
    in the synthesis of neurotransmitters dopamine, GABA, norepinephrine, and serotonin

   -Calcium
    In your brain, calcium regulates neurotransmitter synthesis and release, neuronal excitability, 
    and is involved in long-term potentiation for long-term memory formation

   -Phosphorous
    Precursor to ATP for neuron energy
    Precursor to Phospholipids which form cell structures of neurons
    Assists in neuroplasticity in forming new neuron connections


   -Zinc
    -Zinc is integral to the synthesis of proteins, the regulation of signaling cascades, 
   gene transcription and neurotransmitter transport. It’s involved in DNA repair and 
   synthesis and methylation.
  -Zinc inhibits NMDA receptors which reduces glutamate toxicity. And zinc modulates 
   the activity of proteins such as receptors and enzymes that are involved in the 
    regulation of macromolecules, the regulation of signaling cascades and 
    gene transcription, and transport processes.
  -Low zinc levels are found in depression, and the lower the level the more severe 
   the depression. Zinc increases serotonin uptake in select brain regions which 
   increases the efficacy of antidepressants. And it reduces depression because 
   is increases BDNF.
    

   -Selenium
    precursor to glutathione which protects dopamine neurons from
   oxidation stress




FINAL NOTE: Although this is for ADHD, since I am not using extreme
            stimulants to dramatically increase DA, NE, Serotonin, etc.;
            this same nootropic stack can in fact be used for 
            non ADHD people as long as you  pay attention to the 
            blood pressure decreases warnings for L-theanine and
            ashwagandha.