Automated Microbial Community Reconstruction via Multi-Modal Data Fusion and Bayesian Network Optimization for Enhanced Biofilm Stability
Abstract: Current methods for reconstructing microbial communities from uncultivated samples, such as metagenomics and metabolomics, offer fragmented views of complex interactions. This research introduces a novel framework, MetaComReconstruct, for comprehensive microbial community reconstruction and optimization, combining genomic, proteomic, and metabolomic data through a multi-modal data fusion approach underpinned by a Bayesian network. MetaComReconstruct leverages advanced machine learning algorithms to infer microbial interactions, predict community dynamics, and optimize conditions for enhanced biofilm stability, directly impacting industrial bioprocessing and environmental remediation applications. The framework demonstrates potential for a 20-30% improvement in biofilm resilience and predictability in industrial settings within 5-7 years.
**1. Introductio